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Related publications (12)

Modelling transport time to trauma centres and 30-day mortality in road accidents in Switzerland: an exploratory study

BACKGROUND: Rapid access to a trauma centre for severely injured road accident victims, conceptualised as the Golden Hour, links access time to definitive treatment within 1 hour of trauma with reduced risks of morbidity and mortality. Access times have no ...

E M H SWISS MEDICAL PUBLISHERS LTD2021

On the Importance of Providing a Tangible Haptic Response for Training Cardiopulmonary Resuscitation in Virtual Reality

Ronan Boulic, Bruno Herbelin, Mathias Guy Delahaye

The current approach to train Cardiopulmonary Resuscitation (CPR) is to employ a mannequin device replicating the physical properties of a real human head and torso. This aims to ensure a correct transfer of the cardiac massage location, amplitude and freq ...

The Eurographics Association2021

Synthesis of diphenoxyadamantane alkylamines with pharmacological interest

Stewart Cole, Anthony Vocat

In this work, the synthesis and the pharmacological evaluation of diphenoxyadamantane alkylamines Ia-f and IIa-f is described. The new diphenoxy-substituted adamantanes share structural features present in trypanocidal and antitubercular agents. 1-Methylpi ...

PERGAMON-ELSEVIER SCIENCE LTD2019

Safely Managed Hygiene: A Risk-Based Assessment of Handwashing Water Quality

Timothy R. Julian, Matthew Eric Verbyla

Sustainable Development Goal (SDG) Indicator 6.2.1 requires household handwashing facilities to have soap and water, but there are no guidelines for handwashing water quality. In contrast, drinking water quality guidelines are defined: water must be "free ...

2019

3-Dimensional Ultrasound Imaging for Medical Telesonography: Algorithms and Architectures

Aya Mohamed Naguib Ahmed Ibrahim

Enabling telemedicine in Ultrasound (US) imaging, i.e. telesonography, is until today just a wish. Although US has incomparable advantages such as safety in use, lower cost and complexity, and capability to be utilized in many applications, it is limited i ...

EPFL2018

Reconstruction and systems analysis of metabolism in apicomplexan parasites Toxoplasma gondii and Plasmodium falciparum

Stepan Tymoshenko

Understanding of metabolism in disease-causing microorganisms promotes drug design through the identification of the enzymes whose activity is indispensable for important cellular functions of the pathogens. Nowadays such understanding arises from experime ...

EPFL2015

Metabolic Needs and Capabilities of Toxoplasma gondii through Combined Computational and Experimental Analysis

Jens Nielsen, Rebecca Oppenheim, Vassily Hatzimanikatis, Stepan Tymoshenko, Dominique Soldati-Favre

Toxoplasma gondii is a human pathogen prevalent worldwide that poses a challenging and unmet need for novel treatment of toxoplasmosis. Using a semi-automated reconstruction algorithm, we reconstructed a genome-scale metabolic model, ToxoNet1. The reconstr ...

Public Library Science2015

Infection Dynamics and Immune Response in a Newly Described Drosophila-Trypanosomatid Association

Bruno Lemaitre, Anna Dostalova

Trypanosomatid parasites are significant causes of human disease and are ubiquitous in insects. Despite the importance of Drosophila melanogaster as a model of infection and immunity and a long awareness that trypanosomatid infection is common in the genus ...

American Society for Microbiology2015

Assessing the Impact of Stochasticity for Operating Theater Sizing

Jean-Sébastien Tancrez

Over the last few decades, rational health care management and, in particular, operating theater planning, has attracted increased attention from practitioners and from the scientific community. However, although the operating theater environment is clearl ...

Elsevier2013

Antimalarial and antitubercular nostocarboline and eudistomin derivatives: synthesis, in vitro and in vivo biological evaluation

Simone Bonazzi, Luc Patiny, Rosario Scopelliti, Karl Gademann, Stewart Cole

The synthesis of nine nostocarboline derivatives with substitutions of the 2-methyl group by alkyl, aryl and functionalized residues, 10 symmetrical bis cationic dimers linking 6-Cl-norharmane through the 2-position and fifteen derivatives of the marine al ...

2010

Potent and Selective Antiplasmodial Activity of the Cyanobacterial Alkaloid Nostocarboline and its Dimers

Karl Gademann

The quaternary β-carbolinium alkaloid nostocarboline from the cyanobacterium Nostoc 78-12A and ten bis-cationic dimeric derivatives were evaluated against four protozoan parasites and low micromolar values against Trypanosoma brucei, submicromolar values a ...

2008

Isolation of Aerucyclamides C and D and Structure Revision of Microcyclamide 7806A: Heterocyclic Ribosomal Peptides from Microcystis aeruginosa PCC 7806 and Their Antiparasite Evaluation

Karl Gademann, Cyril Portmann

Aerucyclamides C and D were isolated from the cyanobacterium Microcystis aeruginosa PCC 7806, and their structures established by NMR spectroscopy and chemical transformation and degradation. Acidic hydrolysis of aerucyclamide C (CF3CO2H, H2O) resulted in ...

2008

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