Explores the conformational and functional flexibility of Hsp70 molecular chaperones, focusing on folding intermediates and the Hsp70 functional cycle.
Delves into protein folding principles, emphasizing sequence's role in determining structure and exploring thermodynamics and intermolecular interactions.
Explores protein folding, amino acids, RNA translation, and attractive forces, emphasizing the importance of native state conformation and compact structures.
Explores the evolution and function of protein-repair machineries, emphasizing the role of ATP-fueled unfolding machines in preventing protein aggregation and promoting proper folding.
Explores proteostasis regulation through chaperone interactions and post-translational modifications, revealing insights into protein quality control mechanisms.
By Tatjana Tchumatchenko explores dynamical response functions in neuroscience, emphasizing the role of linear response functions in understanding neural activity.