Publications related to Synovial fluid

Enhancing Chondrocyte Biosynthetic Activities: Harnessing the Power of Loading-Induced Evolved Temperature

Chondrocytes within articular cartilage possess the capacity to perceive and react to signals generated by the typical load-bearing actions of daily life, such as walking or running. Articular cartilage is predominantly oriented toward compression-based fu ...

EPFL2024

Morphological assessment of cartilage and osteoarthritis in clinical practice and research: Intermediate-weighted fat-suppressed sequences and beyond

Tom Hilbert

Magnetic resonance imaging (MRI) is widely regarded as the primary modality for the morphological assessment of cartilage and all other joint tissues involved in osteoarthritis. 2D fast spin echo fat-suppressed intermediate-weighted (FSE FS IW) sequences w ...

SPRINGER2023

In-vivo investigation of electrochemical behavior of Ti and CoCrMo alloy in human synovial fluids

Yueyue Bao

With the development of modern medical techniques, the application of orthopedic implants has been continually increasing in recent years. Passive materials, such as Ti and its alloys as well as CoCrMo alloys, are widely used in artificial joints due to th ...

EPFL2023

A Review on Finite Element Modeling and Simulation of the Anterior Cruciate Ligament Reconstruction

Dimitar Yuriev Stanev

The anterior cruciate ligament (ACL) constitutes one of the most important stabilizing tissues of the knee joint whose rapture is very prevalent. ACL reconstruction (ACLR) from a graft is a surgery which yields the best outcome. Taking into account the com ...

FRONTIERS MEDIA SA2020

Influence of Bovine Serum Albumin (BSA) on the Tribocorrosion Behaviour of a Low Carbon CoCrMo Alloy in Simulated Body Fluids

Stefano Mischler, Shoufan Cao, Choshun Yoneyama

Tribocorrosion, as the interaction between mechanical wear and electrochemical corrosion, has been found to be the main problem causing the failure and limiting the lifetime of metal-on-metal artificial hip joints. Better understanding of the tribocorrosio ...

2020

Triple Contrast CT Method Enables Simultaneous Evaluation of Articular Cartilage Composition and Segmentation

Goran Lovric

Early degenerative changes of articular cartilage are detected using contrast-enhanced computed tomography (CT) with a cationic contrast agent (CA). However, cationic CA diffusion into degenerated cartilage decreases with proteoglycan depletion and increas ...

2020

Synchrotron MicroCT Reveals the Potential of the Dual Contrast Technique for Quantitative Assessment of Human Articular Cartilage Composition

Goran Lovric

Dual contrast micro computed tomography (CT) shows potential for detecting articular cartilage degeneration. However, the performance of conventional CT systems is limited by beam hardening, low image resolution (full-body CT), and long acquisition times ( ...

2020

Tailoring the Mechanical Properties of Tissue Engineering Scaffolds made from Decellularized Cartilage

Jens Antons

Due to its limited regeneration capacity, articular cartilage defects are considered a frequent clinical problem. Initial cartilage defects, if left untreated, will progress in severity over time and can eventually lead to degenerative joint diseases such ...

EPFL2019

Decellularised tissues obtained by a CO2-philic detergent and supercritical CO2

Dominique Pioletti, Pierre-Etienne Bourban, Nathalie Hirt-Burri, Matteo Gregorio Modesto Marascio, Jens Antons, Pierre-Arnaud Aeberhard, Giulia Weissenberger

Tissue decellularisation has gained much attention in regenerative medicine as an alternative to synthetic materials. In decellularised tissues, biological cues can be maintained and provide cellular environments still unmet by synthetic materials. Supercr ...

2018

Rationalizing the In Vivo Degradation of Metal-on-Metal Artificial Hip Joints Using Tribocorrosion Concepts

Stefano Mischler, Shoufan Cao

In this study, the in vivo degradation of metal-on-metal (MoM) artificial hip joints was assessed based on the present state of the art concepts of tribocorrosion. A recently developed tribocorrosion model, based on the combination of mechanical and corros ...

Natl Assoc Corrosion Eng2017

Tribocorrosion under fluid lubrication : modeling wear of CoCrMo artificial hip joints

Shoufan Cao

Wear is still the key problem causing the failure and limiting the lifetime of artificial hip joints, especially for the polymer acetabular cup in the metal-on-polymer and ceramic-on-polymer articulations. To reduce the wear, metal-on-metal articulation ha ...

EPFL2016

In vivo electrochemical corrosion study of a CoCrMo biomedical alloy in human synovial fluids

Stefano Mischler

The present study was initiated with the aim to assess the in vivo electrochemical corrosion behaviour of CoCrMo biomedical alloys in human synovial fluids in an attempt to identify possible patient or pathology specific effects. For this, electrochemical ...

Elsevier2015

Tribocorrosion of passive metals in the mixed lubrication regime: theoretical model and application to metal-on-metal artificial hip joints

Stefano Mischler, Shoufan Cao

Wear is a key problem limiting the lifetime and performance of total hip arthroplasty. The synovial fluid, acting as lubricant, can alleviate the wear of implants but also introduces corrosion. The interaction of mechanical wear and electrochemical corrosi ...

Elsevier2015

Impact of synovial fluid flow on temperature regulation in knee cartilage

Dominique Pioletti, Philippe Abdel Sayed, Valérie Hélène Emilie Malfroy Camine, Mohamadreza Nassajian Moghadam

Several studies have reported an increase of temperature in cartilage submitted to cyclic sinusoidal loading. The temperature increase is in part due to the viscous behavior of this tissue, which partially dissipates the input mechanical energy into heat. ...

Elsevier2015

Peptide ligands for targeting and retention of nanoparticles and protein therapeutics in articular cartilage

Dominique André Rothenfluh

Osteoarthritis (OA) is one of the most common causes of pain and disability. Currently, non-surgical treatment is limited to analgesic and anti-inflammatory drugs, which are not capable of either modifying the disease process or regenerate damaged parts in ...

EPFL2009

Thrombin-sensitive photodynamic agents: A novel strategy for selective synovectomy in rheumatoid arthritis

Hubert van den Bergh

Protease-sensitive macromolecular prodrugs have attracted interest for bio-responsive drug delivery to sites with up-regulated proteolytic activities such as inflammatory or cancerous lesions. Here we report the development of a novel polymeric photosensit ...

2009

Engineering of human meniscus substitute

Anna Marsano

Injuries to the meniscus are often treated by partial or total meniscectomy, which is known to be associated with detrimental changes in joint function, ultimately increasing the risk of early degenerative joint diseases. Surgical approaches currently in u ...

EPFL2006

Gene Expression in Synovial Membrane Cells After Intraarticular Delivery of Plasmid-Linked Superparamagnetic Iron Oxide Particles—A Preliminary Study in Sheep

Heinrich Hofmann, Alke Fink, Benedikt Steitz

This study evaluated in vivo gene deliver y and subsequent gene expression within cells of the synovium in the presence of static and pulsating magnetic field application following intraar ticular injection of super paramagnetic iron oxide nanopar ticles l ...

2006

Intraarticular application of superparamagnetic nanoparticles and their uptake by synovial membrane—an experimental study in sheep

Heinrich Hofmann, Alke Fink, Benedikt Steitz, Mathieu Chastellain

A superparamagnetic iron oxide nanoparticle, coated with polyvinyl alcohol, (PVA-SPION) and its fluorescently functionalized analogue (amino-PVA-Cy3.5-SPION) were compared in vivo as proof of principle for future use in magnetic drug targeting in inflammat ...

2005

Methodology description for detection of cellular uptake of PVA coated superparamagnetic iron oxide nanoparticles (SPION) in synovial cells of sheep

Heinrich Hofmann, Alke Fink, Mathieu Chastellain

The detection of superparamagnetic iron oxide nanoparticles (SPION) in synoviocytes is reported. Synoviocytes were incubated for 2, 12, 24 and 48 h with 1.5 mg/ml of PVA coated SPION under the influence of magnets (12 h). Particles were well tolerated by t ...

2005