Publications related to Hepatic encephalopathy

Neurometabolic profiles of bile duct ligated rats after the treatment with an urease inhibitor – 1H MRS dataset

1H MRS in the cerebellum was used to study the effect of 2-octynohydroxamic acid (2-octynoHA) treatment on the brain of bile duct ligated (BDL) rats (type C hepatic encephalopathy). The study included four groups of rats: negative control group (rats recei ...

Zenodo2023

New insights into rodent brain microstructure and metabolism in hepatic encephalopathy

Jessie Julie Mosso

Type C hepatic encephalopathy (HE) is a severe neuropsychiatric complication of chronic liver disease, for which the prognosis is poor in the absence of liver transplantation. Cirrhosis in type C HE leads to a toxic accumulation of ammonia in the blood, wh ...

EPFL2023

Lessons on brain edema in HE: from cellular to animal models and clinical studies

Cristina Ramona Cudalbu, Katarzyna Pierzchala, Jessie Julie Mosso

Brain edema is considered as a common feature associated with hepatic encephalopathy (HE). However, its central role as cause or consequence of HE and its implication in the development of the neurological alterations linked to HE are still under debate. I ...

SPRINGER/PLENUM PUBLISHERS2023

Overview of oxidative stress findings in hepatic encephalopathy: From cellular and ammonium-based animal models to human data

Cristina Ramona Cudalbu, Dunja Simicic

Oxidative stress is a natural phenomenon in the body. Under physiological conditions intracellular reactive oxygen species (ROS) are normal components of signal transduction cascades, and their levels are maintained by a complex antioxidants systems partic ...

ACADEMIC PRESS INC ELSEVIER SCIENCE2022

Advanced metabolite mapping at ultra-high field using 1H-MRS, 1H-MRSI and macromolecules: applications in a rat model of type C hepatic encephalopathy

Dunja Simicic

Magnetic Resonance Spectroscopy (MRS) is the only technique capable of measuring a large number of metabolites simultaneously in vivo. Ultra-high magnetic fields (UHF) combined with ultra-short echo time (TE) sequences allow the detection of high-quality 1 ...

EPFL2022

Recent Developments on the Use of Nanomaterials for the Treatment of Epilepsy

Sandrine Gerber, Sara María Garcia Pedrero

Epilepsy affects more than 40 million people worldwide, constituting one of the most debilitating disorders of the Central Nervous System (CNS). It results from an imbalance in the electrical activity of neurons, which is primarily mediated by calcium ions ...

2022

Spatial proteogenomics reveals distinct and evolutionarily conserved hepatic macrophage niches

Bart Deplancke, Wouter Saelens

The liver is the largest solid organ in the body, yet it remains incompletely characterized. Here we present a spatial proteogenomic atlas of the healthy and obese human and murine liver combining single-cell CITEseq, single-nuclei sequencing, spatial tran ...

CELL PRESS2022

Development and applications of hyperpolarized 13C and 1H MR spectroscopy of cerebral metabolism at ultra-high field

Emmanuelle Ines Flatt

This thesis is composed of four studies centered on investigating cerebral metabolism using magnetic resonance spectroscopy (MRS) of hyperpolarized and non-hyperpolarized compounds at ultra-high field. In the first two chapters, we studied longitudinally t ...

EPFL2021

C-reactive protein and white matter microstructural changes in COVID-19 patients with encephalopathy

Alessandra Griffa

Encephalopathy is a neurological complication of COVID-19. The objective of this exploratory study is to investigate the link between systemic inflammation and brain microstructural changes (measured by diffusion-weighted imaging) in patients with COVID-19 ...

SPRINGER WIEN2021

Emerging functions of the nuclear receptor LRH-1 in liver physiology and pathology

Kristina Schoonjans, Hadrien Charles Edouard Demagny, Yu Sun

Nuclear receptors play pleiotropic roles in cell differentiation, development, proliferation, and metabolic processes to govern liver physiology and pathology. The nuclear receptor, liver receptor homolog-1 (LRH-1, NR5A2), originally identified in the live ...

2021

SMN Depleted Mice Offer a Robust and Rapid Onset Model of Nonalcoholic Fatty Liver Disease

Bernard Schneider

BACKGROUND & AIMS: Nonalcoholic fatty liver disease (NAFLD) is considered a health epidemic with potential devastating effects on the patients and the healthcare systems. Current preclinical models of NAFLD are invariably imperfect and generally take a lon ...

2021

Iron status influences non-alcoholic fatty liver disease in obesity through the gut microbiome

Xavier Fernandez-Real Girona

Background: The gut microbiome and iron status are known to play a role in the pathophysiology of nonalcoholic fatty liver disease (NAFLD), although their complex interaction remains unclear. Results: Here, we applied an integrative systems medicine approa ...

2021

Longitudinal osmotic and neurometabolic changes in young rats with chronic cholestatic liver disease

Cristina Ramona Cudalbu, Veronika Rackayová

Type C hepatic encephalopathy (type C HE) is increasingly suspected in children with chronic liver disease (CLD), and believed to underlie long-term neurocognitive difficulties. The molecular underpinnings of type C HE in both adults and children are incom ...

Nature Research2020

Longitudinal neurometabolic changes in the hippocampus of a rat model of chronic hepatic encephalopathy

Cristina Ramona Cudalbu, Katarzyna Pierzchala, Jocelin Grosse, Veronika Rackayová

Background & Aims: The sequence of events in hepatic encephalopathy (HE) remains unclear. Using the advantages of in vivo 1H-MRS (9.4T) we aimed to analyse the time-course of disease in an established model of type C HE by analysing the longitudinal change ...

2019

Brain Edema in Chronic Hepatic Encephalopathy

Cristina Ramona Cudalbu

Brain edema is a common feature associated with hepatic encephalopathy (HE). In patients with acute HE, brain edema has been shown to play a crucial role in the associated neurological deterioration. In chronic HE, advanced magnetic resonance imaging (MRI) ...

ELSEVIER - DIVISION REED ELSEVIER INDIA PVT LTD2019

Association between Brain and Plasma Glutamine Levels in Healthy Young Subjects Investigated by MRS and LC/MS

Lijing Xin, Yuhei Takado

Both glutamine (Gln) and glutamate (Glu) are known to exist in plasma and brain. However, despite the assumed relationship between brain and plasma, no studies have clarified the association between them. Proton magnetic resonance spectroscopy (MRS) was se ...

2019

Endogenous nicotinamide riboside metabolism protects against diet-induced liver damage

Carlos Canto Alvarez, Sofia Moco, Joanna Ratajczak, Miriam Valera Alberni

Supplementation with the NAD(+) precursor nicotinamide riboside (NR) ameliorates and prevents a broad array of metabolic and aging disorders in mice. However, little is known about the physiological role of endogenous NR metabolism. We have previously show ...

Nature Research2019

Autophagy regulates lipid metabolism through selective turnover of NCoR1

Johan Auwerx

Selective autophagy ensures the removal of specific soluble proteins, protein aggregates, damaged mitochondria, and invasive bacteria from cells. Defective autophagy has been directly linked to metabolic disorders. However how selective autophagy regulates ...

Springer2019

Bile acids drive colonic secretion of glucagon-like-peptide 1 and peptide-YY in rodents

Kristina Schoonjans

A large number of glucagon-like-peptide-1(GLP-1)- and peptide-YY (PYY)-producing L cells are located in the colon, but little is known about their contribution to whole body metabolism. Since bile acids (BAs) increase GLP-1 and PYY release, and since BAs s ...

AMER PHYSIOLOGICAL SOC2019

Interference of silver nanoparticles with essential metal homeostasis in a novel enterohepatic fish in vitro system

Kristin Schirmer

Silver nanoparticle toxicity has been extensively studied in several vertebrate cells. Its correlation with cellular essential metal homeostasis, however, has largely been overlooked. In this study, we used a novel in vitro model of a fish enterohepatic sy ...

ROYAL SOC CHEMISTRY2019