Concept

Synaptogenesis

Related publications (28)

Dynamic spatiotemporal patterns of brain connectivity reorganize across development

Alessandra Griffa, Patric Hagmann, Marie Schaer, Emeline Mullier

Late human development is characterized by the maturation of high-level functional processes, which rely on reshaping of white matter connections, as well as synaptic density. However, the relationship between the whole-brain dynamics and the underlying wh ...

MIT PRESS2020

Dendritic Voltage Recordings Explain Paradoxical Synaptic Plasticity: A Modeling Study

Wulfram Gerstner, Matthias Chinyen Tsai, Laureline Logiaco, Claire Meissner-Bernard

Experiments have shown that the same stimulation pattern that causes Long-Term Potentiation in proximal synapses, will induce Long-Term Depression in distal ones. In order to understand these, and other, surprising observations we use a phenomenological mo ...

FRONTIERS RESEARCH FOUNDATION2020

Somatostatin enhances visual processing and perception by suppressing excitatory inputs to parvalbumin-positive interneurons in V1

Carl Petersen, Graham Knott, Catherine Maclachlan, Seung-Hee Lee

Somatostatin (SST) is a neuropeptide expressed in a major subtype of GABAergic interneurons in the cortex. Despite abundant expression of SST and its receptors, their modulatory function in cortical processing remains unclear. Here, we found that SST appli ...

2020

Estimating the Readily-Releasable Vesicle Pool Size at Synaptic Connections in the Neocortex

Henry Markram, Eilif Benjamin Muller, Srikanth Ramaswamy, Rodrigo de Campos Perin, Giuseppe Chindemi, Natali Barros Zulaica

Previous studies based on the 'Quantal Model' for synaptic transmission suggest that neurotransmitter release is mediated by a single release site at individual synaptic contacts in the neocortex. However, recent studies seem to contradict this hypothesis ...

2019

Role of BMP Signaling for the Formation of Auditory Brainstem Nuclei and Large Auditory Relay Synapses

Ralf Schneggenburger, Christopher Clark, Elin Kristina Kronander

Large excitatory synapses are found at specific points in the neuronal circuits of the auditory brainstem, to enable fast information transfer and the preservation of acoustic timing information. The extracellular cues and signaling mechanisms that lead to ...

WILEY2019

Cellular, Synaptic and Network Effects of Acetylcholine in the Neocortex

Henry Markram, Srikanth Ramaswamy, Daniel Keller, Cristina Colangelo, Polina Shichkova

The neocortex is densely innervated by basal forebrain (BF) cholinergic neurons. Long-range axons of cholinergic neurons regulate higher-order cognitive function and dysfunction in the neocortex by releasing acetylcholine (ACh). ACh release dynamically rec ...

2019

The gut microbiota influences skeletal muscle mass and function in mice

Johan Auwerx, Hongbo Zhang, Walter Wahli

The functional interactions between the gut microbiota and the host are important for host physiology, homeostasis, and sustained health. We compared the skeletal muscle of germ-free mice that lacked a gut microbiota to the skeletal muscle of pathogen-free ...

AMER ASSOC ADVANCEMENT SCIENCE2019

Nutritional Intervention for Developmental Brain Damage: Effects of Lactoferrin Supplementation in Hypocaloric Induced Intrauterine Growth Restriction Rat Pups

Kim Do, Yohan Van de Looij, Camille Larpin

Introduction: Intrauterine Growth Restriction (IUGR) refers to an impaired development of the fetus and hence results in adverse neurodevelopmental and psychiatric consequences later in life. Lactoferrin (Lf) is a glycoprotein present in milk that has alre ...

2019