Publications related to Periodontal disease

Plasma neurofilament light and phosphorylated tau 181 as biomarkers of Alzheimer's disease pathology and clinical disease progression

Bénédicte Marie Maréchal, Jonas Richiardi, Christopher Clark

BackgroundTo assess the performance of plasma neurofilament light (NfL) and phosphorylated tau 181 (p-tau181) to inform about cerebral Alzheimer's disease (AD) pathology and predict clinical progression in a memory clinic setting.MethodsPlasma NfL and p-ta ...

2021

Scaffold requirements for periodontal regeneration with enamel matrix derivative proteins

John Christopher Plummer, Laurent Mirko Dejace, Matteo Gregorio Modesto Marascio, Alessandra Apicella, Peter Fischer

Periodontitis affects the attachment of natural teeth, and infection or inflammation associated with periodontitis may affect peri-implant tissues. Enamel matrix derivative (EMD) proteins provide stimulation for self-regeneration of the damaged tissue when ...

Elsevier Science Bv2017

Molecular dynamics simulations of the intrinsically disordered protein amelogenin

John Christopher Plummer, Matteo Gregorio Modesto Marascio, Alessandra Apicella, Vincenzo Colangelo

Amelogenin refers to a class of intrinsically disordered proteins that are the major constituents of enamel matrix derivative (EMD), an extract of porcine fetal teeth used in regenerative periodontal therapy. Modifications in molecular conformation induced ...

Taylor & Francis Inc2017

The Influence of Arginine on the Response of Enamel Matrix Derivative (EMD) Proteins to Thermal Stress: Towards Improving the Stability of EMD-Based Products

John Christopher Plummer, Matteo Gregorio Modesto Marascio, Alessandra Apicella, Raffaele Mezzenga, Peter Fischer

In a current procedure for periodontal tissue regeneration, enamel matrix derivative (EMD), which is the active component, is mixed with a propylene glycol alginate (PGA) gel carrier and applied directly to the periodontal defect. Exposure of EMD to physio ...

Public Library Science2015

Classification of daily-life postural transitions using trunk-worn wearable barometric pressure sensor

Kamiar Aminian, Anisoara Ionescu, Fabien Massé, Alan Kevin Bourke

Distinguishing sedentary from dynamic behavior is essential in addressing disease conditions that are influenced by mobility. Event-based activity recognition algorithms essentially rely on accurate classification of siting and standing postural transition ...

2013

Hydro-mechanical coupling in the periodontal ligament: A porohyperelastic finite element model

John Botsis, Matteo Galli, Joël Cugnoni, Marzio Bergomi

Harmonic tension–compression tests at 0.1, 0.5 and 1 Hz on hydrated bovine periodontal ligament (PDL) were numerically simulated. The process was modeled by finite elements (FE) within the framework of poromechanics, with the objective of isolating the con ...

Elsevier2011

Systemic inflammation disrupts the developmental program of white matter

Yohan Van de Looij, Elie Saliba

Perinatal inflammation is a major risk factor for neurological deficits in preterm infants. Several experimental studies have shown that systemic inflammation can alter the programming of the developing brain. However, these studies do not offer detailed p ...

2011

Three-dimensional morphometry of strained bovine periodontal ligament using synchrotron radiation-based tomography

John Botsis, Joël Cugnoni, Marzio Bergomi, Marco Stampanoni, Philipp Schneider

The periodontal ligament (PDL) is a highly vascularized soft connective tissue. Previous studies suggest that the viscous component of the mechanical response may be explained by the deformation-induced collapse and expansion of internal voids (i.e. chiefl ...

2010

Load Response of Periodontal Ligament: Assessment of Fluid Flow, Compressibility, and Effect of Pore Pressure

John Botsis, Marzio Bergomi, Aïssa Mellal

The periodontal ligament (PDL) functions both in tension and in compression. The presence of an extensive vascular network inside the tissue suggests a significant contribution of the fluid phase to the mechanical response. This study examined the load res ...

2010

The role of the fluid phase in the viscous response of bovine periodontal ligament

John Botsis, Joël Cugnoni, Marzio Bergomi

The mechanical response of the periodontal ligament (PDL) is complex. This tissue responds as a hyperelastic solid when pulled in tension while demonstrating a viscous behavior under compression. This intricacy is reflected in the tissue's morphology, whic ...

2010

Mechanical response of periodontal ligament: Effects of specimen geometry, preconditioning cycles and time lapse

John Botsis, Marzio Bergomi

This study was conducted as part of research line addressing the mechanical response of periodontal ligament (PDL) to tensile-compressive sinusoidal loading The aim of the present project was to determine the effect of three potential sources of variabilit ...

2009

Regional structural characteristics of bovine periodontal ligament samples and their suitability for biomechanical tests

Marzio Bergomi

Mechanical testing of the periodontal ligament requires a practical experimental model. Bovine teeth are advantageous in terms of size and availability, but information is lacking as to the anatomy and histology of their periodontium. The aim of this study ...

2008

Experimental and numerical investigations on the fluid contribution to the tensile-compressive mechanical behavior of the bovine periodontal ligament

Marzio Bergomi

Orthodontic treatments are all based on the experimental evidence that teeth can be forced to move in the dental arch by means of applied mechanical forces. Since it allows for prediction of dental mobility, the mechanical characterization of the tissues i ...

EPFL2008

Starch-induced implant periapical lesion: A case report

This paper reports an implant periapical lesion (IPL) with a previously unreported etiology. The presence of an osteolytic area around the apex and around the middle portion of a stable Straumann hollow-screw implant was found on periapical radiographs 3.5 ...

2007

With applications to the periodontal ligament: a nonlinear large strain viscoelastic law

Jörn Justiz

The soft tissue, called periodontal ligament (PDL), that connects the alveolar bone and the tooth root accounts to a large extent for the mobility, stress-distribution and, due to its viscoelastic properties, damping of the bone-tooth complex. The accurate ...

EPFL2004