Publications related to Atrium (heart)

A comprehensive stroke risk assessment by combining atrial computational fluid dynamics simulations and functional patient data

Stroke, a major global health concern often rooted in cardiac dynamics, demands precise risk evaluation for targeted intervention. Current risk models, like the CHA 2 DS 2 -VASc \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepa ...

Nature Portfolio2024

A mathematical model that integrates cardiac electrophysiology, mechanics, and fluid dynamics: Application to the human left heart

Alfio Quarteroni, Luca Dede'

We propose a mathematical and numerical model for the simulation of the heart function that couples cardiac electrophysiology, active and passive mechanics and hemodynamics, and includes reduced models for cardiac valves and the circulatory system. Our mod ...

Wiley2023

A comprehensive mathematical model for cardiac perfusion

Alfio Quarteroni, Francesco Regazzoni, Christian Vergara

The aim of this paper is to introduce a new mathematical model that simulates myocardial blood perfusion that accounts for multiscale and multiphysics features. Our model incorporates cardiac electrophysiology, active and passive mechanics, hemodynamics, v ...

Nature Portfolio2023

Quantification of the Phenomena Affecting Reflective Arterial Photoplethysmography

Nikolaos Stergiopoulos, Georgios Rovas, Vasiliki Bikia

Photoplethysmography (PPG) is a widely emerging method to assess vascular health in humans. The origins of the signal of reflective PPG on peripheral arteries have not been thoroughly investigated. We aimed to identify and quantify the optical and biomecha ...

MDPI2023

lifex-cfd: An open-source computational fluid dynamics solver for cardiovascular applications

Alfio Quarteroni, Luca Dede', Marco Fedele

Computational fluid dynamics (CFD) is an important tool for the simulation of the cardiovascular function and dysfunction. Due to the complexity of the anatomy, the transitional regime of blood flow in the heart, and the strong mutual influence between the ...

Elsevier2023

A single-beat algorithm to discriminate farfield from nearfield bipolar voltage electrograms from the pulmonary veins

Jean-Marc Vesin, Adrian Luca, Vincent Schlageter

Background Superimposition of farfield (FF) and nearfield (NF) bipolar voltage electrograms (BVE) complicates the confirmation of pulmonary vein (PV) isolation after catheter ablation of atrial fibrillation. Our aim was to develop an automatic algorithm ba ...

SPRINGER2023

Impact of atrial fibrillation on left atrium haemodynamics: A computational fluid dynamics study

Alfio Quarteroni, Luca Dede'

We analyse the haemodynamics of the left atrium, highlighting differences between healthy individuals and patients affected by atrial fibrillation. The computational study is based on patient-specific geometries of the left atria to simulate blood flow dyn ...

PERGAMON-ELSEVIER SCIENCE LTD2022

Correlation between conduction velocity and frequency analysis in patients with atrial fibrillation using high-density charge mapping

Jean-Marc Vesin, Lam Dang

Spectral analysis of atrial signals has been used to identify regions of interest in atrial fibrillation (AF). However, the relationship to the atrial substrate is unclear. In this study, we compare regions with dominant frequency (DF), simultaneously dete ...

SPRINGER HEIDELBERG2022

Hemodynamics of the heart's left atrium based on a Variational Multiscale-LES numerical method

Alfio Quarteroni, Filippo Menghini

In this paper, we investigate the haemodynamics of a left atrium (LA) by proposing a computational model suitable to provide physically meaningful fluid dynamics indications and detailed blood flow characterization. In particular, we consider the incompres ...

ELSEVIER2021

ECG-Based Indices to Characterize Persistent Atrial Fibrillation Before and During Stepwise Catheter Ablation

Jean-Marc Vesin, Adrian Luca, Etienne Pruvot

Background: Consistently successful patient outcomes following catheter ablation (CA) for treatment of persistent atrial fibrillation (pers-AF) remain elusive. We propose an electrocardiogram (ECG) analysis designed to (1) refine selection of patients most ...

2021

POD-Enhanced Deep Learning-Based Reduced Order Models for the Real-Time Simulation of Cardiac Electrophysiology in the Left Atrium

Alfio Quarteroni, Andrea Manzoni

The numerical simulation of multiple scenarios easily becomes computationally prohibitive for cardiac electrophysiology (EP) problems if relying on usual high-fidelity, full order models (FOMs). Likewise, the use of traditional reduced order models (ROMs) ...

FRONTIERS MEDIA SA2021

A Proof of Concept for Computational Fluid Dynamic Analysis of the Left Atrium in Atrial Fibrillation on a Patient-Specific Basis

Alfio Quarteroni, Davide Forti, Filippo Menghini

Atrial fibrillation (AF) is associated with a fivefold increase in the risk of cerebrovascular events, being responsible of 15-18% of all strokes. The morphological and functional remodeling of the left atrium (LA) caused by AF favors blood stasis and, con ...

ASME2020

An intergrid transfer operator using radial basis functions with application to cardiac electromechanics

Alfio Quarteroni

In the framework of efficient partitioned numerical schemes for simulating multiphysics PDE problems, we propose using intergrid transfer operators based on radial basis functions to accurately exchange information among different PDEs defined in the same ...

SPRINGER2020

Ventricular response regularity in atrial fibrillation and its relationship to successful catheter ablation

Jean-Marc Vesin, Adrian Luca, Etienne Pruvot

Atrial rate is known to modulate ventricular response during atrial fibrillation (AF). The resulting pulse irregularity translates into widely varying inter-beat intervals (IBIs) extracted from recorded surface electrocardiogram (ECG) activity. In AF, the ...

IEEE2020

Computational fluid dynamics of blood flow in an idealized left human heart

Alfio Quarteroni, Filippo Menghini

We construct an idealized computational model of the left human heart for the study of the blood flow dynamics in the left atrium and ventricle. We solve the Navier-Stokes equations in the ALE formulation and we prescribe the left heart wall displacement b ...

Wiley2019

A 1D computer model of the arterial circulation in horses: An important resource for studying global interactions between heart and vessels under normal and pathological conditions

Nikolaos Stergiopoulos, Patrick Segers

Arterial rupture in horses has been observed during exercise, after phenylephrine administration or during parturition (uterine artery). In human pathophysiological research, the use of computer models for studying arterial hemodynamics and understanding n ...

2019

Can one detect atrial fibrillation using a wrist-type photoplethysmographic device?

Jean-Marc Vesin, Célestin Leupi, Mathieu Lemay, Sibylle Fallet, Etienne Pruvot, Philippe Renevey

This study aims at evaluating the potential of a wrist-type photoplethysmographic (PPG) device to discriminate between atrial fibrillation (AF) and other types of rhythm. Data from 17 patients undergoing catheter ablation of various arrhythmias were proces ...

SPRINGER HEIDELBERG2019

Severe and uniform bi-atrial remodeling measured by dominant frequency analysis in persistent atrial fibrillation unresponsive to ablation

Jean-Marc Vesin, Adrian Luca, Andréa Buttu, Etienne Pruvot

Background High values of ECG and intracardiac dominant frequency (DF) are indicative of significant atrial remodeling in persistent atrial fibrillation (peAF). We hypothesized that patients with peAF unresponsive to ablation display higher ECG and intraca ...

2020

A Non-linear Filter to Detect Atrial Activation from Intracardiac Electrograms

Jean-Marc Vesin, Sasan Yazdani, Andréa Buttu, Etienne Pruvot

Atrial activation (AA) detection during atrial fibrillation (AF) can be considered as a first step in estimating AF characteristics such as the AF cycle length. The detection of AA from intracardiac electrograms (EGM) remains challenging due to the constan ...

2017

Isogeometric approximation of cardiac electrophysiology models on surfaces: An accuracy study with application to the human left atrium

Alfio Quarteroni, Luca Dede', Toni Mikael Lassila, Alessandro Samuele Patelli, Andrea Bartezzaghi

We consider Isogeometric Analysis in the framework of the Galerkin method for the spatial approximation of cardiac electrophysiology models defined on NURBS surfaces; specifically, we perform a numerical comparison between basis functions of degree p >= 1 ...

Elsevier2017