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Related publications (31)

Update on yesterday's dose-Use of delivery log-files for daily adaptive proton therapy (DAPT)

Marco Matter

In daily adaptive proton therapy (DAPT), the treatment plan is re-optimized on a daily basis. It is a straightforward idea to incorporate information from the previous deliveries during the optimization to refine this daily proton delivery. A feedback sign ...

2020

Iterative Design and Evaluation of a Tangible Robot-Assisted Handwriting Activity for Special Education

Pierre Dillenbourg, Thibault Lucien Christian Asselborn, Ayberk Özgür, Arzu Güneysu Özgür, Barbara Bruno, Wafa Monia Benkaouar Johal, Elmira Yadollahi

In this article we investigate the role of interactive haptic-enabled tangible robots in supporting the learning of cursive letter writing for children with attention and visuomotor coordination issues. We focus on the two principal aspects of handwriting ...

2020

Delivery, Beam and Range Monitoring in Particle Therapy in a Highly Innovative Integrated Design

Luca Bottura, Enrico Felcini

The design of a particle therapy system that integrates an innovative beam delivery concept based on a static toroidal gantry and an imaging configuration suitable for beam and online range monitoring is proposed and discussed. Such approach would provide ...

2020

Gene replacement therapy provides benefit in an adult mouse model of Leigh syndrome

Johan Auwerx

Mutations in nuclear-encoded mitochondrial genes are responsible for a broad spectrum of disorders among which Leigh syndrome is the most common in infancy. No effective therapies are available for this severe disease mainly because of the limited capabili ...

2020

Lactate enhancing compounds and uses thereof

Pierre Magistretti, Sylvain Eric Lengacher, Charles Léonard Finsterwald

Abstract of the invention: The present invention relates to new agents useful for stimulating release of lactate by astrocytes. The invention further relates to methods of preparation, formulations and therapeutic uses of those agents, notably for the prev ...

2020

Classification of Metal-Based Drugs according to Their Mechanisms of Action

Paul Joseph Dyson

Metal-based drugs and imaging agents are extensively used in the clinic for the treatment and diagnosis of cancers and a wide range of other diseases. The current clinical arsenal of compounds operate via a limited number of mechanisms, whereas new putativ ...

CELL PRESS2020

Magnetic Design of a Superconducting Toroidal Gantry for Hadron Therapy

Luca Bottura, Enrico Felcini, Bertrand Dutoit, Bertrand Dutoit

Hadron and proton therapy are cutting edge techniques for cancer treatment and a great development of specialized medical centers and research facilities is foreseen in the next decades. One of the main obstacles to the penetration of the use of charged pa ...

IEEE Institute of Electrical and Electronics Engineers2020

Gait analysis in children with cerebral palsy: bridging the gap between the laboratory and real life

Lena Carcreff

Like 17 million people worldwide, an individual with cerebral palsy (CP) does not have the opportunity to walk harmoniously in society due to long-life impairments in movement and posture. The natural course of CP can be modulated by treatments and therapi ...

EPFL2020

Directional Local Field Potentials in the Subthalamic Nucleus During Deep Brain Implantation of Parkinson's Disease Patients

André Mercanzini, Thuy Anh Khoa Nguyen

Segmented deep brain stimulation leads feature directional electrodes that allow for a finer spatial control of electrical stimulation compared to traditional ring-shaped electrodes. These segmented leads have demonstrated enlarged therapeutic windows and ...

2020

Multifunctional hybrid alginate-based hydrogels for cell immobilization

Luca Szabó

Cell therapy could be a solution for many diseases that currently pose a huge health burden on patients. Especially, cell therapies based on cell microencapsulation are of great interest. Immunoprotection of cells would allow to avoid the need for immunosu ...

EPFL2020

Multicomponent Alginate-Derived Hydrogel Microspheres Presenting Hybrid Ionic-Covalent Network and Drug Eluting Properties

Sandrine Gerber, François Rémi Pierre Noverraz, Luca Szabó

The development of multifunctional encapsulation biomaterials could help the translation of cell‐based therapies into standard medical care. One of the major hurdles in the field of encapsulated cell transplantation is the current lack of materials present ...

Wiley-VHCA AG2020

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