Publications related to Elastic fiber

Bio-Enhanced Neoligaments Graft Bearing FE002 Primary Progenitor Tenocytes: Allogeneic Tissue Engineering & Surgical Proofs-of-Concept for Hand Ligament Regenerative Medicine

Sandra Jaccoud, Corinne Scaletta, Philippe Abdel Sayed, Lee Ann Laurent-Applegate, Nathalie Hirt-Burri, Laurent Alexis Clément Vannay, Cédric Peneveyre, Annick Jeannerat, Alexis Laurent, Joachim Meuli, Axelle Thomas

Hand tendon/ligament structural ruptures (tears, lacerations) often require surgical reconstruction and grafting, for the restauration of finger mechanical functions. Clinical-grade human primary progenitor tenocytes (FE002 cryopreserved progenitor cell so ...

MDPI2023

Mimicking Loading-Induced Cartilage Self-Heating in Vitro Promotes Matrix Formation in Chondrocyte-Laden Constructs with Different Mechanical Properties

Dominique Pioletti, Peyman Karami, Naser Nasrollahzadeh Mamaghani, Theofanis Stampoultzis, Yanheng Guo

Articular cartilage presents a mechanically sensitive tissue. Chondrocytes, the sole cell type residing in the tissue, perceive and react to physical cues as signals that significantly modulate their behavior. Hyaline cartilage is a connective tissue with ...

2023

Bioprinting of Cartilaginous Auricular Constructs Utilizing an Enzymatically Crosslinkable Bioink

Nicolas Antoine Vincent Broguiere, Philipp Fisch

Bioprinting of functional tissues could overcome tissue shortages and allow a more rapid response for treatments. However, despite recent progress in bioprinting, and its outstanding ability to position cells and biomaterials in a precise 3D manner, its su ...

WILEY-V C H VERLAG GMBH2021

Repetitive regime of highly focused liquid microjets for needle-free injection

Christophe Moser, Paul Delrot, Jan Krizek

Fast liquid jets are investigated for use as a needle-free drug delivery system into an elastic tissue such as skin. Using smaller jet diameters in a repetitive regime can mitigate bruising and pain associated with current injectors. In this study, we aim ...

Nature Research2020

Biofilms deform soft surfaces and disrupt epithelia

Alexandre Louis André Persat, Alice Cont, Tamara Rossy

During chronic infections and in microbiota, bacteria predominantly colonize their hosts as multicellular structures called biofilms. A common assumption is that biofilms exclusively interact with their hosts biochemically. However, the contributions of me ...

2020

Strategies for improving the repair of focal cartilage defects

Dominique Pioletti, Philippe Abdel Sayed

Articular cartilage, together with skin, was predicted to be one of the first tissues to be successfully engineered. However cartilage repair remains nowadays still elusive, as we are still not able to overcome the hurdles of creating biomaterials correspo ...

Future Medicine Ltd2015

Fiber connectivity and bifurcation diagrams of almost toric integrable systems

Tudor Ratiu

We describe the bifurcation diagrams of almost toric integrable Hamiltonian systems on a four dimensional symplectic manifold M, not necessarily compact. We prove that, under a weak assumption, the connectivity of the fibers of the induced singular Lagrang ...

Int Press Boston, Inc2015

Mechanical properties of peripheral stress fibers in adherent cells spreading on patterned substrates

Céline Jeanne Labouesse

Many cellular processes require or depend on mechanical feedback from the cell's micro-environment. For example, the local organization of the actin cytoskeleton is known to adapt to the physical properties of the extracellular matrix. To gain better under ...

EPFL2015

Hydrogel-coated microfluidic channels for cardiomyocyte culture

Déborah Heintze

The research areas of tissue engineering and drug development have displayed increased interest in organ-on-a-chip studies, in which physiologically or pathologically relevant tissues can be engineered to test pharmaceutical candidates. Microfluidic techno ...

Royal Soc Chemistry2013

Experimental investigation of collagen waviness and orientation in the arterial adventitia using confocal laser scanning microscopy

Michaël Unser, Nikolaos Stergiopoulos, Daniel Sage, Alessandra Griffa, Aristotelis Agianniotis, Jelle Tymen Christiaan Schrauwen

Mechanical properties of the adventitia are largely determined by the organization of collagen fibers. Measurements on the waviness and orientation of collagen, particularly at the zero-stress state, are necessary to relate the structural organization of c ...

Springer Verlag2012

Role of elastin anisotropy in structural strain energy functions of arterial tissue

Nikolaos Stergiopoulos, Edouard Fonck

The vascular wall exhibits nonlinear anisotropic mechanical properties. The identification of a strain energy function (SEF) is the preferred method to describe its complex nonlinear elastic properties. Earlier constituent-based SEF models, where elastin i ...

Springer-Verlag2011

Elastic components for prosthetic skin

Stéphanie Lacour

We have developed two fundamental components to manufacture a prosthetic skin: a stretchable pressure sensor formed of piezoelectric elastomer/ferroelectret multilayer sandwiched between stretchable electrodes and stretchable thin-film transistors. The com ...

Ieee Service Center, 445 Hoes Lane, Po Box 1331, Piscataway, Nj 08855-1331 Usa2011

Arterial remodeling using a constituent-based approach

Alkiviadis Tsamis

This thesis is intended to contribute to the field of biomechanics of growth and remodeling of arteries. The work focuses particularly on growth and remodeling caused by sustained hypertension, increased blood flow, and ageing. A structure-based constituti ...

EPFL2010

Effect of aging on elastin functionality in human cerebral arteries

Michaël Unser, Nikolaos Stergiopoulos, Daniel Sage, Edouard Fonck, Jean Fasel

Aging affects elastin, a key component of the arterial wall integrity and functionality. Elastin degradation in cerebral vessels is associated with cerebrovascular disease. The goal of this study is to assess the biomechanical properties of human cerebral ...

ASA2009

A three-dimensional elastic plastic damage constitutive law for bone tissue

Alain Curnier

Motivated by mechanical analysis of bones and bone-implant systems, a 3D constitutive law describing the macroscopic mechanical behaviour of both cortical and trabecular bone in cyclic (not fatigue) overloads is developed. The proposed model which mathemat ...

Springer Verlag2009

On the in-series and in-parallel contribution of elastin assessed by a structure-based biomechanical model of the arterial wall

Nikolaos Stergiopoulos, Sylvain Roy, Alkiviadis Tsamis, Gilles Prod'Hom

Earlier experimental work on decellularized arteries revealed the existence of significant residual stresses within the arterial wall, which are released upon chemical removal of vascular smooth muscle in normal arteries causing substantial radial expansio ...

2008

Effect of elastin degradation on carotid wall mechanics as assessed by a constituent-based biomechanical model

Nikolaos Stergiopoulos, Sylvain Roy, Luca Augsburger, Edouard Fonck, Gilles Prod'Hom

Arteries display a nonlinear anisotropic behavior dictated by the elastic properties and structural arrangement of its main constituents, elastin, collagen, and vascular smooth muscle. Elastin provides for structural integrity and for the compliance of the ...

2007

Myofibroblast contraction activates latent TGF-beta1 from the extracellular matrix

Jean-Jacques Meister, Boris Hinz, Pierre Jean Arnould Wipff

The conjunctive presence of mechanical stress and active transforming growth factor beta1 (TGF-beta1) is essential to convert fibroblasts into contractile myofibroblasts, which cause tissue contractures in fibrotic diseases. Using cultured myofibroblasts a ...

Rockefeller University Press2007

Mechanisms of interstitial flow-induced remodeling of fibroblast-collagen cultures

Melody Swartz

Interstitial fluid flow, critical for macromolecular transport, was recently shown to drive fibroblast differentiation and perpendicular cell and matrix alignment in 3D collagen cultures. Here we explore the mechanisms underlying this flow-induced cell and ...

Springer US2006

Etude du phénomène de l'élimination de la mémoire de forme du bois densifié par post-traitement thermo-hydro-mécanique

Owing to its porous cellular structure and polymeric components, wood can be easily shaped in its transversal direction when it is heated and has sufficient water content. Thanks to this thermohydrous behaviour many manufacturing processes such as densific ...

EPFL2004