Publications related to Human feces

Bioengineering human mini-intestines with in vivo-like complexity and function

Biological research heavily relies on the use of animal models, which has made it difficult to answer specific questions about human biology and disease. However, with the advent of human organoids - miniature versions of tissues generated in 3D human stem ...

EPFL2023

Fate of parasites and viruses in calcium hydroxide-treated urine in relation to temperature and moisture content

Tamar Kohn, Loïc Decrey

Human urine can be used as fertilizer and technologies, such as alkaline-urine treatment, are being developed to enable easier re-use. There is, however, a risk of pathogens being present in the urine. This hygiene assessment examined inactivation of three ...

2022

Thermal Stress Interacts With Surgeonfish Feces to Increase Coral Susceptibility to Dysbiosis and Reduce Tissue Regeneration

Leïla Ezzat

Dysbiosis of coral microbiomes results from various biotic and environmental stressors, including interactions with important reef fishes which may act as vectors of opportunistic microbes via deposition of fecal material. Additionally, elevated sea surfac ...

Frontiers Media SA2021

Detection of trace metals in biogas using extractive electrospray ionization high-resolution mass spectrometry

Christian Ludwig, Mohamed Tarik

On-line measurements of metal emissions in energy conversion systems at very low concentrations are difficult to perform using existing techniques. Metals are of high importance due to their detrimental impact on human health, the environment and various i ...

Pergamon-Elsevier Science Ltd2021

Water and sanitation hub in Mali. Reasons for an architecture seminar

Riccardo Vannucci

What is the goal of a five-day seminar for the (architectural) design of a ‘water and sanitation hub’ in Mali? What does one want to achieve, or rather, what is the seminar meant to ‘disseminate’? To begin with, what is a ‘water and sanitation hub’? It is ...

EUNSA. Ediciones Universidad de Navarra, S.A.2020

Salt enhances the thermostability of enteroviruses by stabilizing capsid protein interfaces

Tamar Kohn, Matteo Dal Peraro, Simon Meister, Alessio Prunotto

Enteroviruses are common agents of infectious disease that are spread by the fecal-oral route. They are readily inactivated by mild heat, which causes the viral capsid to disintegrate or undergo conformational change. While beneficial for the thermal treat ...

American Society for Microbiology2020

Health risks for sanitation service workers along a container-based urine collection system and resource recovery value chain

Tamar Kohn, Simon Schindelholz, Timothy R. Julian

Container-based sanitation (CBS) within a comprehensive service system value chain offers a low-cost sanitation option with potential for revenue generation, but may increase microbial health risks to sanitation service workers. This study assessed occupat ...

2019

Safely Managed Hygiene: A Risk-Based Assessment of Handwashing Water Quality

Matthew Eric Verbyla, Timothy R. Julian

Sustainable Development Goal (SDG) Indicator 6.2.1 requires household handwashing facilities to have soap and water, but there are no guidelines for handwashing water quality. In contrast, drinking water quality guidelines are defined: water must be "free ...

2019

Associations between usual diet and gut microbiota composition: results from the Milieu Interieur cross-sectional study

Jacques Fellay

Background: Diet is widely recognized as one of the main modifiable drivers of gut microbiota variability, and its influence on microbiota composition is an active area of investigation. ...

OXFORD UNIV PRESS2019

High time-resolution simulation of E. coli on hands reveals large variation in microbial exposures amongst Vietnamese farmers using human excreta for agriculture

Ana Karina Pitol Garcia, Timothy R. Julian

Infectious disease transmission is frequently mediated by the environment, where people's movements through and interactions with the environment dictate risks of infection and/or illness. Capturing these interactions, and quantifying their importance, off ...

2018

Pepper mild mottle virus as a water quality indicator

Jason Robert Torrey

Pepper mild mottle virus (PMMoV) was recently found to be the most abundant RNA virus in human feces, and is a plant virus belonging to the genus Tobamovirus in the family Virgoviridae. When in human feces, it is of dietary origin from peppers and their pr ...

NATURE PUBLISHING GROUP2018

Virus inactivation in stored human urine, sludge and animal manure under typical conditions of storage or mesophilic anaerobic digestion

Tamar Kohn, Loïc Decrey

Viruses represent major disease transmitting agents carried by human excreta and animal manure. Understanding virus inactivation is therefore essential in preventing microbial spread due to inadequate treatment of these materials. Here, we investigated the ...

Royal Soc Chemistry2017

Reaction extents: A Divide-and-Conquer Approach for Kinetic Model Identification

Dominique Bonvin, Julien Léo Billeter

Obtaining reliable wastewater treatment process models is critical for the application of model-based design, operation, and automation. For example, Masic et al. (2014) explored the use of an observer designed for nonlinear processes to estimate nitrite i ...

2017

Ammonia as an in-situ sanitizer: influence of virus genome type on inactivation

Tamar Kohn, Loïc Decrey, Shinobu Kazama

Treatment of human excreta and animal manure (HEAM) is key in controlling the spread of persistent enteric pathogens such as viruses. The extent of virus inactivation during HEAM storage and treatment appeared to vary with virus genome type, though the rea ...

American Society for Microbiology2016

Virus inactivation mechanisms in human urine and fecal sludge

Loïc Decrey

Water, sanitation and hygiene interventions are among the most significant health interventions addressing the worldwide burden of diarrheal disease and environmental enteropathy. Sanitizing human excreta and animal manure (HEAM) is a critical step in redu ...

EPFL2015

Ammonia as an in-situ sanitizer: inactivation kinetics and mechanisms of the ssRNA virus MS2 by NH3

Tamar Kohn, Loïc Decrey, Shinobu Kazama, Kai Udert

Sanitizing human and animal waste (e.g., urine, fecal sludge or grey water) is a critical step in reducing the spread of disease and ensuring microbially safe reuse of waste materials. Viruses are particularly persistent pathogens and can be transmitted th ...

2015

Another Shp on the Horizon for Bile Acids

Kristina Schoonjans, Alessia Perino

Bile acid metabolism is tightly controlled due to the toxic effects of bile acid overload. In this issue, research from the Feng lab reports Shp2 as a novel integrator of hepatic bile acid and FGF15/FGF19 signaling, adding another layer of complexity to th ...

Cell Press2014

Differential stress reaction of human colon cells to oleic-acid-stabilized and unstabilized ultrasmall iron oxide nanoparticles

Therapeutic engineered nanoparticles (NPs), including ultrasmall superparamagnetic iron oxide (USPIO) NPs, may accumulate in the lower digestive tract following ingestion or injection. In order to evaluate the reaction of human colon cells to USPIO NPs, th ...

Dove Medical Press Ltd2014

UVC inactivation of dsDNA and ssRNA viruses in water: UV fluences and a qPCR-based approach to evaluate decay on viral infectivity

Tamar Kohn, Anna Carratala Ripolles

Disinfection by low-pressure monochromatic ultraviolet (UVC) radiation (253.7 nm) became an important technique to sanitize drinking water and also wastewater in tertiary treatments. In order to prevent the transmission of waterborne viral diseases, the an ...

Springer2014

The Receptor TGR5 Protects the Liver From Bile Acid Overload During Liver Regeneration in Mice

Kristina Schoonjans

Many regulatory pathways are involved in liver regeneration after partial hepatectomy (PH) to initiate growth, protect liver cells, and sustain functions of the remnant liver. Bile acids (BAs), whose levels rise in the blood early after PH, stimulate both ...

Wiley-Blackwell2013