Explores Tau pathologies in Alzheimer's and related disorders, covering hyperphosphorylation, propagation, genetic associations, and therapeutic interventions.
Explores protein aggregation control through optimal strategies, inhibitors, and spatial regulation using liquid compartments, shedding light on drug interventions and aggregate dynamics.
Explores protein aggregation in neurodegenerative diseases, emphasizing the need to rethink treatment strategies and understand the role of post-translational modifications.
Explores the mechanisms of ALS, focusing on SOD1 pathology, including toxic gain of function, protein misfolding, ER stress, and mitochondrial dysfunction.
Delves into protein aggregation mechanisms using C. elegans, covering misfolding, aggregation pathways, kinetics, chaperones, and stochastic nucleation.
Explores beta-hairpins in polyglutamine protein aggregation, focusing on Huntington's disease and the molecular mechanisms behind toxic fibril formation.
