Publications related to Diathesis–stress model

Adolescent Stress-Induced Ventral Hippocampus Redox Dysregulation Underlies Behavioral Deficits and Excitatory/Inhibitory Imbalance Related to Schizophrenia

Maria del Carmen Sandi Perez, Dogukan Hazar Ülgen, Thamyris Silva

Background and hypothesis: Redox dysregulation has been proposed as a convergent point of childhood trauma and the emergence of psychiatric disorders, such as schizophrenia (SCZ). A critical region particularly vulnerable to environmental insults during ad ...

2024

Fatigue behavior of transverse attachments under constant and variable amplitude loading from a Swiss motorway bridge

Alain Nussbaumer, Davide Leonetti, Yukina Takai

This paper investigates the fatigue behavior of non-load-carrying transverse welded steel attachments by reporting on an experimental characterization under constant and variable amplitude loading. Fatigue cracks have been monitored using DIC and ACPD tech ...

Elsevier Sci Ltd2023

The effects of war on Ukrainian research

Gaétan Jean A de Rassenfosse, Wolf-Hendrik Peter Uhlbach, Tetiana Murovana

The ongoing war in Ukraine has profoundly impacted the Ukrainian scientific community. Numerous researchers have either emigrated or transitioned to alternate professions. For those who remain in research, the destruction of civil infrastructure and psycho ...

Springernature2023

Blunted Glucocorticoid Responsiveness to Stress Causes Behavioral and Biological Alterations That Lead to Posttraumatic Stress Disorder Vulnerability

Maria del Carmen Sandi Perez, Jocelin Grosse, Olivia Zanoletti, Simone Astori, Marie-Isabelle Guillot de Suduiraut, Sophie Elizabeth Walker, Silvia Monari

Background: Understanding why only a subset of trauma-exposed individuals develop posttraumatic stress disorder is critical for advancing clinical strategies. A few behavioral (deficits in fear extinction) and biological (blunted glucocorticoid levels, sma ...

2023

Thermo-hydro-mechanical behavior of energy barrettes: Field experiments and numerical simulations

Lyesse Laloui, Elena Ravera, Alessandro Francesco Rotta Loria

Over the past two decades, the thermo-hydro-mechanical behavior of earth-contact structures such as piles, walls, slabs, and tunnels, which simultaneously provide structural support and energy supply, has been studied through various field experiments and ...

ELSEVIER2023

Agency Deficits in a Human Genetic Model of Schizophrenia: Insights From 22q11DS Patients

Olaf Blanke, Nathan Quentin Faivre, Roy Salomon, Maude Schneider, Oliver Alan Kannape, Mariia Kaliuzhna, Henrique Galvan Debarba

Schizophrenia is a chronic and disabling mental illness characterized by a disordered sense of self. Current theories suggest that deficiencies in the sense of control over one’s actions (Sense of Agency, SoA) may underlie some of the symptoms of schizophr ...

2022

Identification of biopsychological trait markers in functional neurological disorders

Serafeim Loukas

Weber et al. provide evidence in support of a stress-diathesis model of functional neurological disorders. They identify trauma history in the form of emotional neglect as a psychological risk factor, and reduced hippocampus and amygdala volume as a predis ...

OXFORD UNIV PRESS2022

Stress effects on the impedance and ferroelectricity of PVDF-BiFeO3-MWCNT films using xanthan gum as dispersant

Frank Nüesch, Francis Owusu

Composite films based on dispersions of bismuth ferrite (BiFeO3) in polyvinylidene fluoride (PVDF) matrixes were prepared in the presence of multiwalled-carbon-nanotubes (MWCNT), using xanthan gum (XG) as dispersant. Films were prepared by spin coating and ...

ELSEVIER SCIENCE SA2022

Role of Stress History on the Swelling-Shrinkage Behavior of Compacted Scaly Clay

Alessio Ferrari

Compacted scaly clays are complex geomaterials widely used for the realization of dam cores and waste dump liners. This research aims to investigate the swelling/shrinkage behavior of these geomaterials subjected in an oedometric cell to complex hydromecha ...

ASCE-AMER SOC CIVIL ENGINEERS2022

Drained Axial Pipe-Soil Resistance at Low Confinement Using Tilt Table and Direct Shear Tests

Roba Houhou

Establishing a reliable value for the axial pipe-soil interface resistance is critical for the design of offshore pipelines. Over the last few years, several independent research groups have modified existing methodologies or devised new testing setups to ...

ASCE-AMER SOC CIVIL ENGINEERS2022

The thermally activated deformation behaviour of single-crystalline microcast aluminium wires

Andreas Mortensen, Léa Deillon, Suzanne Godelieve Alphonsine Verheyden

A microcasting process is used to produce high aspect ratio ( > 30) monocrystalline pure aluminium wires with a diameter between 14 and 115 mu m. The role of thermal activation in the plastic deformation of these microwires is measured by means of (single) ...

PERGAMON-ELSEVIER SCIENCE LTD2022

Effect of Native Oxide on Stress in Silicon Nanowires: Implications for Nanoelectromechanical Systems

Yusuf Leblebici, Zuhal Tasdemir, Mohammad Nasr Esfahani

Understanding the origins of intrinsic stress in Si nanowires (NWs) is crucial for their successful utilization as transducer building blocks in next-generation, miniaturized sensors based on nanoelectromechanical systems (NEMS). With their small size lead ...

AMER CHEMICAL SOC2022

Antibody-Coated Wearable Organic Electrochemical Transistors for Cortisol Detection in Human Sweat

Danick Briand, Silvia Demuru, Marwan El Chazli, Jaemin Kim

The dysregulation of the hormone cortisol is related to several pathological states, and its monitoring could help prevent severe stress, fatigue, and mental diseases. While wearable antibody-based biosensors could allow real-time and simple monitoring of ...

AMER CHEMICAL SOC2022

Title: "Labels Matter: Is it stress or is it Trauma?"

Maria del Carmen Sandi Perez

In neuroscience, the term 'Stress' has a negative connotation because of its potential to trigger or exacerbate psychopathologies. Yet in the face of exposure to stress, the more common reaction to stress is resilience, indicating that resilience is the ru ...

SPRINGERNATURE2021

Maladaptive emotion regulation traits predict altered corticolimbic recovery from psychosocial stress

Dimitri Nestor Alice Van De Ville

Background: Adaptive recovery from stress promotes healthy cognitive affective functioning, whereas maladaptive recovery is linked to poor psychological outcomes. Neural regions, like the anterior cingulate and hippocampus, play critical roles in psychosoc ...

ELSEVIER2021

Role of mean stress on fatigue behavior of a 316L austenitic stainless steel in LWR and air environments

Philippe Spätig, Hans-Peter Seifert

Mean stress effects on fatigue life of a stainless steel in air and boiling water reactor (BWR) environments were evaluated by load-controlled tests. In stress-life, non-zero mean stresses increase life in low cycle fatigue regime in both environments and ...

ELSEVIER SCI LTD2021

Fatigue of reinforced UHPFRC members and monitoring of fatigue action effects on bridges

Bartlomiej Wojciech Sawicki

The objective of this thesis is to develop knowledge and methods to prevent fatigue failure of bridges. The Fatigue Limit State is investigated from both the demand (S) and resistance (R) side. The S-part focuses on reduction of uncertainties through monit ...

EPFL2021

Therapeutic potential of glutathione-enhancers in stress-related psychopathologies

Maria del Carmen Sandi Perez, Sarah Catherine Sonnay, Fiona Hollis, Ioannis Zalachoras, Pascal Steiner, Eva Ramos Fernandez, Laia Morato Fornaguera

The mammalian brain has high energy demands, which may become higher in response to environmental challenges such as psychogenic stress exposure. Therefore, efficient neutralization of reactive oxygen species that are produced as a by-product of ATP synthe ...

2020

Locomotion in virtual environments predicts cardiovascular responsiveness to subsequent stressful challenges

Maria del Carmen Sandi Perez, Nathalie Heidi Meyer, João Pedro de Matos Rodrigues, Stephan Streuber, Erik Hans Jakob Studer

Individuals differ in their physiological responsiveness to stressful challenges, and stress potentiates the development of many diseases. Heart rate variability (HRV), a measure of cardiac vagal break, is emerging as a strong index of physiological stress ...

Nature Research2020

Stress management in the context of induced seismicity in subsurface reservoirs

Barnaby Padraig Fryer

The stress state of the subsurface has been shown to have an influence on a number of key processes. For example, the criticality of the stress state indicates how large stress changes need to be before a fault begins to slip, the mean effective stress con ...

EPFL2020