Publications related to Anticonvulsant

Hardware Implementation of Digital Signal Processing Algorithms for Programmable Epilepsy Control Systems

Epilepsy is a common chronic neurological disorder that causes recurring seizures and affects more than 50 million people worldwide. Implantable medical devices (IMDs) are regarded as effective tools to cure patients who suffer from refractory epilepsy. Se ...

EPFL2023

Recent Developments on the Use of Nanomaterials for the Treatment of Epilepsy

Sandrine Gerber, Sara María Garcia Pedrero

Epilepsy affects more than 40 million people worldwide, constituting one of the most debilitating disorders of the Central Nervous System (CNS). It results from an imbalance in the electrical activity of neurons, which is primarily mediated by calcium ions ...

2022

Highly Sensitive Detection of the Antidepressant Fluoxetine With an Extended Gate Field Effect Transistor

Mihai Adrian Ionescu, Shokoofeh Sheibani

Fluoxetine (FL) is one of the selective serotonin reuptake inhibitors, which is used as an anti-depressant, as well as anti-panic drug. In this work, a sensor for label-free recognition of trace amounts of FL is introduced, which is based on an extended ga ...

IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC2022

Methods for functional connectivity and morphometry in neonatal neuroimaging to study neurodevelopment

Serafeim Loukas

Preterm birth is a major pediatric health problem that perturbs the genetically determined program of corticogenesis of the developing brain. As a consequence, prematurity has been strongly associated with adverse long-term neurodevelopmental outcome that ...

EPFL2021

Extended Gate Field Effect Transistor Based Sensor for Detection of Trace Amounts of Anti-Depressant Drug

Mihai Adrian Ionescu, Shokoofeh Sheibani

Citalopram hydrobromide (CP) is a selective serotonin reuptake inhibitor for the treatment of the depressive disorder. In this work, a novel label-free recognition method based on an extended gate field-effect transistor (EGFET) for selective determination ...

IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC2020

A Self-Learning Methodology for Epileptic Seizure Detection with Minimally Supervised Edge Labeling

David Atienza Alonso, Amir Aminifar, Damián Pascual Ortiz

Epilepsy is one of the most common neurological disorders and affects over 65 million people worldwide. Despite the continuing advances in anti-epileptic treatments, one third of the epilepsy patients live with drug resistant seizures. Besides, the mortali ...

2019

Implantable Autonomous Wireless Closed-loop Bio-electronics for Epilepsy Control

Reza Ranjandish

Implantable electronic medical device (IEMD) is an emerging technology that plays an important role in the treatment of several neurological disorders such as epilepsy, especially in the cases of drug-resistant epilepsy. Recent developments and studies sho ...

EPFL2019

Nutritional Intervention for Developmental Brain Damage: Effects of Lactoferrin Supplementation in Hypocaloric Induced Intrauterine Growth Restriction Rat Pups

Kim Do, Yohan Van de Looij, Camille Larpin

Introduction: Intrauterine Growth Restriction (IUGR) refers to an impaired development of the fetus and hence results in adverse neurodevelopmental and psychiatric consequences later in life. Lactoferrin (Lf) is a glycoprotein present in milk that has alre ...

2019

e-Glass: A Wearable System for Real-Time Detection of Epileptic Seizures

David Atienza Alonso, Amir Aminifar, Dionisije Sopic

Today, epilepsy is one of the most common chronic diseases affecting more than 65 million people worldwide and is ranked number four after migraine, Alzheimer’s disease, and stroke. Despite the recent advances in anti-epileptic drugs, one-third of the epil ...

2018

Bioluminescent sensor proteins for point-of-care therapeutic drug monitoring

Rudolf Griss

To ensure efficacy but avoid toxicity, many drugs require monitoring of their concentrations in the patient’s blood during therapy. Currently, therapeutic drug monitoring (TDM) is done in diagnostic laboratories that need trained personnel and expensive in ...

EPFL2013

Partial and full own-body illusions of epileptic origin in a child with right temporoparietal epilepsy

Olaf Blanke, Lukas Heydrich, Christophe Lopez

Partial and full own-body illusions of neurological origin have been claimed crucial to understand the contribution of bodily experience and perception to self-consciousness. Whereas partial body illusions are relatively common and well defined, much less ...

2011

Enhanced long-term microcircuit plasticity in the valproic Acid animal model of autism

Henry Markram, Kamila Markram, Tania Rinaldi, Jean-Vincent Le Bé, Imad Riachi, Guilherme Silva

A single intra-peritoneal injection of valproic acid (VPA) on embryonic day (ED) 11.5 to pregnant rats has been shown to produce severe autistic-like symptoms in the offspring. Previous studies showed that the microcircuitry is hyperreactive due to hyperco ...

2009

Hyper-connectivity and hyper-plasticity in the medial prefrontal cortex in the valproic Acid animal model of autism

Henry Markram, Tania Rinaldi, Catherine Perrodin

The prefrontal cortex has been extensively implicated in autism to explain deficits in executive and other higher-order functions related to cognition, language, sociability and emotion. The possible changes at the level of the neuronal microcircuit are ho ...

2008

Clinical neuroimaging in epileptic patients with autoscopic hallucinations and out-of-body experiences

Olaf Blanke

Autoscopic phenomena are complex illusory perceptions of one's body during which human subjects experience a second own body or double in their environment. Autoscopic phenomena most commonly refer tovisual doubles, although doubles may also be felt or hea ...

2007

Altered neocortical microcircuitry in the valproic acid rat model of autism

Tania Rinaldi

Autism is a wide-spectrum disorder with early childhood onset, affecting general cognitive capabilities and, in particular, complex information processing. Although interesting directions of research start to appear, the precise causes of the disorder and ...

EPFL2006

Linking out-of-body experience and self processing to mental own-body imagery at the temporoparietal junction

Olaf Blanke, Christine Mohr, Peter Andreas Brugger

The spatial unity of self and body is challenged by various philosophical considerations and several phenomena, perhaps most notoriously the "out-of-body experience" (OBE) during which one's visual perspective and one's self are experienced to have departe ...

Society for Neuroscience2005