Publications related to Thyroid hormones

Method for hormone or drug screening in a tissue sample

Cathrin Brisken, Christoph Merten, Yueyun Zhang

The present invention relates to a method for analyzing cellular responsiveness to hormones or drags in a tissue sample based on an alginate-based 3D ex vivo culture system for normal and malignant tissue microstructures and uses thereof. ...

2023

Cryo-EM structure of native human thyroglobulin

Henning Paul-Julius Stahlberg

The thyroglobulin (TG) protein is essential to thyroid hormone synthesis, plays a vital role in the regulation of metabolism, development and growth and serves as intraglandular iodine storage. Its architecture is conserved among vertebrates. Synthesis of ...

Nature Research2022

Extended-gate field-effect transistor with aptamer functionalisation layer for measuring hormone concentration in biofluids and corresponding fabrication method

Mihai Adrian Ionescu, Shokoofeh Sheibani

The present invention concerns a biosensor (1) for sensing stress hormone cortisol concentration in a biofluid (27). The biosensor (1) comprises: an electrical transistor transducer (3) comprising a transistor gate electrode (17); a sensing electrode eleme ...

2022

Dissecting the role of the asparagine synthesis in acute liver injury

Yu Sun

Amino acids are some of the main building stones of life used in a variety of biological processes, such as protein synthesis, energy metabolism or even as precursors for hormone synthesis. How-ever, some of them also participate and coordinate certain cel ...

EPFL2022

The secreted protease Adamts18 links hormone action to activation of the mammary stem cell niche

Cathrin Brisken, Giovanna Ambrosini, Marian Caikovski, Dalya Ataca, Philipp Bucher, Renuga Devi Rajaram, Patrik Aouad, Marie Shamseddin, Céline Berthe Constantin, Csaba Ferenc László, Rachel Marcone

Estrogens and progesterone control breast development and carcinogenesis via their cognate receptors expressed in a subset of luminal cells in the mammary epithelium. How they control the extracellular matrix, important to breast physiology and tumorigenes ...

Nature Research2020

Mechanism and effects of pulsatile GABA secretion from cytosolic pools in the human beta cell

Steinunn Baekkeskov Hanahan, Chiara Cianciaruso, Petra Catalina Schwalie, Edward Allen Phelps

Pancreatic beta cells synthesize and secrete the neurotransmitter GABA (gamma-aminobutyric acid) as a paracrine and autocrine signal to help regulate hormone secretion and islet homeostasis. Islet GABA release has classically been described as a secretory- ...

2019

First-principles calculations of iodine-related point defects in CsPbI3

Joachim Maier, Alessandro Senocrate

We present here first principles hybrid functional calculations of the atomic and electronic structure of several iodine-related point defects in CsPbI3, a material relevant for photovoltaic applications. We show that the presence of neutral interstitial I ...

2019

What is the 'spectral diet' of humans?

Marilyne Andersen, Forrest Simon Webler, Manuel Spitschan

Our visual perception of the world - seeing form and colour or navigating the environment - depends on the interaction of light and matter in the environment. Light also has a more fundamental role in regulating rhythms in physiology and behaviour, as well ...

ELSEVIER2019

Mechanism suppressing charge recombination at iodine defects in CH3NH3PbI3 by polaron formation

Alfredo Pasquarello, Francesco Ambrosio, Julia Anna Wiktor

Metal-halide perovskites exhibit high efficiencies in photovoltaic applications and low recombination rates, despite the high concentrations of intrinsic defects. We here study the hole trapping at the negative iodine interstitial, which corresponds to the ...

Royal Society of Chemistry2018

Novel compartment-specific biosensors reveal a complementary subcellular distribution of bioactive Furin and PC7

Pierpaolo Ginefra

Proprotein Convertases (PCs) constitute a family of serine proteases that activate various hormones, growth factors and cell adhesion molecules by mediating endoproteolytic cleavage of their secreted inactive precursors during their transit in the secret ...

EPFL2018

Progestins used for hormonal contraception in Switzerland: study of their effects on the breast epithelium

Marie Shamseddin

Breast cancer is the most commonly diagnosed cancer and the most common cause of cancer death among women. Hormones have been shown to have a key role in breast development and carcinogenesis. Repeated activation of progesterone receptor (PR) signaling as ...

EPFL2018

European demonstration program on the effect-based and chemical identification and monitoring of organic pollutants in European surface waters

Kristin Schirmer, Juliane Hollender, Anita Orsolya Hidasi, Kevin Thomas, Melis Muz

Growing concern about the adverse environmental and human health effects of a wide range of micropollutants requires the development of novel tools and approaches to enable holistic monitoring of their occurrence, fate and effects in the aquatic environmen ...

Elsevier Science Bv2017

Inkjet-printed microtiter plates for portable electrochemical immunoassays

Hubert Girault, Frédéric Gumy, Andreas Stephan Lesch, Fernando Cortes Salazar, Milica Jovic, Yingdi Zhu, Alexandra Bondarenko

Herein, we present the large-scale fabrication of multiplexed three-electrode sensors used in a point-of-care device platform that couples a magnetic bead-based immunoassay strategy with amperometric detection for rapid and highly sensitive analysis. The m ...

Elsevier Science Sa2017

Extensive Regulation of Diurnal Transcription and Metabolism by Glucocorticoids

Cédric Gobet, Meltem Weger, Frédéric Bruno Martin Gachon, Benjamin Dieter Weger

Altered daily patterns of hormone action are suspected to contribute to metabolic disease. It is poorly understood how the adrenal glucocorticoid hormones contribute to the coordination of daily global patterns of transcription and metabolism. Here, we exa ...

Public Library Science2016

Endocrine hormones and local signals during the development of the mouse mammary gland

Cathrin Brisken, Dalya Ataca

Most of mammary gland development occurs postnatally under the control of female reproductive hormones, which in turn interact with other endocrine factors. While hormones impinge on many tissues and trigger very complex biological responses, tissue recomb ...

Wiley-Blackwell2015

Circadian Clock Characteristics Are Altered in Human Thyroid Malignant Nodules

Daniel Sage, Olivia Mariani, Daniel Andreas Schmitter

Context: The circadian clock represents the body's molecular time-keeping system. Recent findings revealed strong changes of clock gene expression in various types of human cancers. Objective: Due to emerging evidence on the connection between the circadia ...

Endocrine Soc2013

Emerging roles of the corepressors NCoR1 and SMRT in homeostasis

Johan Auwerx, Laurent Mouchiroud, Adrienne Joëlle Laurence Mottis

Epigenetic regulation of gene expression is strongly influenced by the accessibility of nucleosomal DNA or the state of chromatin compaction. In this context, coregulators, including both coactivators and corepressors, are pivotal intermediates that bridge ...

Cold Spring Harbor Laboratory Press2013

Liver receptor homolog-1 is essential for pregnancy

Kristina Schoonjans

Successful pregnancy requires coordination of an array of signals and factors from multiple tissues. One such element, liver receptor homolog-1 (Lrh-1), is an orphan nuclear receptor that regulates metabolism and hormone synthesis(1). It is strongly expres ...

Nature Publishing Group2013

Progesterone/RANKL Is a Major Regulatory Axis in the Human Breast

Cathrin Brisken, Tamara Tanos, Georgios Sflomos, Ayyakkannu Ayyanan, Maryse Fiche, Maria Gutierrez Najera

Estrogens and progesterones are major drivers of breast development but also promote carcinogenesis in this organ. Yet, their respective roles and the mechanisms underlying their action in the human breast are unclear. Receptor activator of nuclear factor ...

American Association for the Advancement of Science2013

Measured binding coefficients for iodine and ruthenium dyes; implications for recombination in dye sensitised solar cells

Shaik Mohammed Zakeeruddin, Robin Humphry-Baker, Filippo de Angelis, Xiong Li

We have measured the binding coefficients of iodine to three dyes used in Dye Sensitised Solar Cells (DSSCs). Binding coefficients are quantified via the effect of iodine binding on the UV-vis spectrum of the dye. From iodine titration curves of dye sensit ...

Royal Society of Chemistry2012