Concept

Fragment-based lead discovery

Related lectures (32)

The ClpXP Proteolytic Complex: Basic Principles to Drug Discovery

Explores the ClpXP proteolytic complex, its drug targeting potential, and antimicrobial applications through compound screening.

Infectious Diseases: Small Molecule Drugs

Explores small molecule drugs for infectious diseases, covering global mortality rates, viral and bacterial injuries, antiviral and antibacterial agents, and the development of COX2 inhibitors.

Enantioselective C-H Activation

Explores enantioselective C-H activation reactions using Cu, Rh, and Ni catalysts for functionalization of olefins, alkynes, and alkenes.

Drug-Induced Liver Injury (DILI): Mechanisms and Mitigation

Delves into Drug-Induced Liver Injury (DILI) mechanisms, metabolism, and mitigation strategies in drug development.

Protein-Ligand Interactions

Explores the principles of protein-ligand interactions, covering methods for measuring affinity and kinetics in drug development.

Small Molecule Drugs: Cardiovascular Diseases

Explores the molecular basis and treatment of cardiovascular diseases, focusing on atherosclerosis, hypertension, and drug therapies.

Chemical Biology Toolsets: Enzyme Inhibition and Metabolic Signaling

Explores enzyme inhibition, metabolic signaling, glycolysis, and isotopic tracing in central carbon metabolism.

Micro-ElectroMechanical Systems (MEMS)

Explores Micro-ElectroMechanical Systems (MEMS) development, ion channels, patch clamp technique, drug discovery, and PDMS integration in microfluidic systems.

Protein Aggregation Kinetics and Drug Discovery

Explores protein aggregation kinetics, drug discovery, and targeting oligomers in misfolding diseases.

Chemical Biology meets Drug Discovery

Explores Chemical Biology, Drug Discovery, enzyme kinetics, and inhibition methods, including competitive and non-competitive inhibition.

AI & Ethics: Business Impact

Delves into the business impact of AI, ethical challenges, and consumer trust in technology.

Chemical Biology Fundamentals

Covers the basics of Chemical Biology, focusing on enzyme inhibitors, metabolic regulation, and the interdisciplinary nature of the field.