Purine metabolismPurine metabolism refers to the metabolic pathways to synthesize and break down purines that are present in many organisms. Purines are biologically synthesized as nucleotides and in particular as ribotides, i.e. bases attached to ribose 5-phosphate. Both adenine and guanine are derived from the nucleotide inosine monophosphate (IMP), which is the first compound in the pathway to have a completely formed purine ring system. Inosine monophosphate is synthesized on a pre-existing ribose-phosphate through a complex pathway (as shown in the figure on the right).
Autocatalytic setAn autocatalytic set is a collection of entities, each of which can be created catalytically by other entities within the set, such that as a whole, the set is able to catalyze its own production. In this way the set as a whole is said to be autocatalytic. Autocatalytic sets were originally and most concretely defined in terms of molecular entities, but have more recently been metaphorically extended to the study of systems in sociology, ecology, and economics.
Murchison meteoriteThe Murchison meteorite is a meteorite that fell in Australia in 1969 near Murchison, Victoria. It belongs to the carbonaceous chondrite class, a group of meteorites rich in organic compounds. Due to its mass (over ) and the fact that it was an observed fall, the Murchison meteorite is one of the most studied of all meteorites. In January 2020, cosmochemists reported that the oldest material found on Earth to date are the silicon carbide particles from the Murchison meteorite, which have been determined to be 7 billion years old, about 2.
ProtocellA protocell (or protobiont) is a self-organized, endogenously ordered, spherical collection of lipids proposed as a stepping stone toward the origin of life. A central question in evolution is how simple protocells first arose and how they could differ in reproductive output, thus enabling the accumulation of novel biological emergences over time, i.e. biological evolution. Although a functional protocell has not yet been achieved in a laboratory setting, the goal to understand the process appears well within reach.
PanspermiaPanspermia () is the hypothesis that life exists throughout the Universe, distributed by space dust, meteoroids, asteroids, comets, and planetoids, as well as by spacecraft carrying unintended contamination by microorganisms. Panspermia is a fringe theory with little support amongst mainstream scientists. Critics argue that it does not answer the question of the origin of life but merely places it on another celestial body. It is also criticized because it cannot be tested experimentally.
RNA worldThe RNA world is a hypothetical stage in the evolutionary history of life on Earth, in which self-replicating RNA molecules proliferated before the evolution of DNA and proteins. The term also refers to the hypothesis that posits the existence of this stage. Alexander Rich first proposed the concept of the RNA world in 1962, and Walter Gilbert coined the term in 1986. Alternative chemical paths to life have been proposed, and RNA-based life may not have been the first life to exist.
AutopoiesisThe term autopoiesis () refers to a system capable of producing and maintaining itself by creating its own parts. The term was introduced in the 1972 publication Autopoiesis and Cognition: The Realization of the Living by Chilean biologists Humberto Maturana and Francisco Varela to define the self-maintaining chemistry of living cells. The concept has since been applied to the fields of cognition, systems theory, architecture and sociology. Niklas Luhmann briefly introduced the concept of autopoiesis to organizational theory.
AutocatalysisA chemical reaction is said to be autocatalytic if one of the reaction products is also a catalyst for the same reaction. Many forms of autocatalysis are recognized. A set of chemical reactions can be said to be "collectively autocatalytic" if a number of those reactions produce, as reaction products, catalysts for enough of the other reactions that the entire set of chemical reactions is self-sustaining given an input of energy and food molecules (see autocatalytic set).
GlycolaldehydeGlycolaldehyde is the organic compound with the formula . It is the smallest possible molecule that contains both an aldehyde group () and a hydroxyl group (). It is a highly reactive molecule that occurs both in the biosphere and in the interstellar medium. It is normally supplied as a white solid. Although it conforms to the general formula for carbohydrates, , it is not generally considered to be a saccharide. Glycolaldehyde as a gas is a simple monomeric structure. As a solid and molten liquid, it exists as a dimer.
Iron–sulfur world hypothesisThe iron–sulfur world hypothesis is a set of proposals for the origin of life and the early evolution of life advanced in a series of articles between 1988 and 1992 by Günter Wächtershäuser, a Munich patent lawyer with a degree in chemistry, who had been encouraged and supported by philosopher Karl R. Popper to publish his ideas. The hypothesis proposes that early life may have formed on the surface of iron sulfide minerals, hence the name.
RibonucleotideIn biochemistry, a ribonucleotide is a nucleotide containing ribose as its pentose component. It is considered a molecular precursor of nucleic acids. Nucleotides are the basic building blocks of DNA and RNA. Ribonucleotides themselves are basic monomeric building blocks for RNA. Deoxyribonucleotides, formed by reducing ribonucleotides with the enzyme ribonucleotide reductase (RNR), are essential building blocks for DNA. There are several differences between DNA deoxyribonucleotides and RNA ribonucleotides.
Earliest known life formsThe earliest known life forms on Earth are believed to be fossilized microorganisms found in hydrothermal vent precipitates, considered to be about 3.42 billion years old. The earliest time for the origin of life on Earth is at least 3.77 billion years ago, possibly as early as 4.28 billion years ago—not long after the oceans formed 4.5 billion years ago, and after the formation of the Earth 4.54 billion years ago. The earliest direct evidence of life on Earth is from microfossils of microorganisms permineralized in 3.
Early EarthEarly Earth is loosely defined as Earth in its first one billion years, or gigayear (Ga, 109y). Early Earth is defined as encompassing approximately the first gigayear in the evolution of the planet from its initial formation in the young Solar System at about 4.55 Ga to sometime in the Archean eon in approximately 3.5 Ga. On the geologic time scale, this comprises all of the Hadean eon, starting with the formation of the Earth about 4.6 billion years ago, and the Eoarchean, starting 4 billion years ago, and part of the Paleoarchean era, starting 3.
Polycyclic aromatic hydrocarbonA polycyclic aromatic hydrocarbon (PAH) is a class of organic compounds that is composed of multiple aromatic rings. The simplest representative is naphthalene, having two aromatic rings and the three-ring compounds anthracene and phenanthrene. PAHs are uncharged, non-polar and planar. Many are colorless. Many of them are found in coal and in oil deposits, and are also produced by the incomplete combustion of organic matter—for example, in engines and incinerators or when biomass burns in forest fires.
EoarcheanThe Eoarchean (ˌiːoʊ.ɑɹˈkiːən; also spelled Eoarchaean) is the first era of the Archean Eon of the geologic record. It spans 400 million years, from the end of the Hadean Eon 4 billion years ago (4000 Mya) to the start of the Paleoarchean Era 3600 Mya. The beginnings of life on Earth have been dated to this era and evidence of archaea and cyanobacteria date to 3500 Mya, comparatively shortly after the Eoarchean. At that time, the atmosphere was without oxygen and the pressure values ranged from 10 to 100 bar (around 10 to 100 times the atmospheric pressure today).
Iron-sulfur proteinIron–sulfur proteins are proteins characterized by the presence of iron–sulfur clusters containing sulfide-linked di-, tri-, and tetrairon centers in variable oxidation states. Iron–sulfur clusters are found in a variety of metalloproteins, such as the ferredoxins, as well as NADH dehydrogenase, hydrogenases, coenzyme Q – cytochrome c reductase, succinate – coenzyme Q reductase and nitrogenase. Iron–sulfur clusters are best known for their role in the oxidation-reduction reactions of electron transport in mitochondria and chloroplasts.
Last universal common ancestorThe last universal common ancestor (LUCA) is the most recent population from which all organisms now living on Earth share common descent—the most recent common ancestor of all current life on Earth. This includes all cellular organisms, but not necessarily viruses. The LUCA is not the first life on Earth; it may have lived among a diversity of other organisms whose descendants all died out. Rather LUCA is the most recent form from which all surviving life on Earth is descended.
Age of EarthThe age of Earth is estimated to be 4.54 ± 0.05 billion years (4.54 × 109 years ± 1%). This age may represent the age of Earth's accretion, or core formation, or of the material from which Earth formed. This dating is based on evidence from radiometric age-dating of meteorite material and is consistent with the radiometric ages of the oldest-known terrestrial material and lunar samples. Following the development of radiometric age-dating in the early 20th century, measurements of lead in uranium-rich minerals showed that some were in excess of a billion years old.
HadeanThe Hadean (heɪˈdiːən,_ˈheɪdiən ) is the first and oldest of the four known geologic eons of Earth's history. It started with the planet's formation about 4.54 Bya, now defined as (4567.30 ± 0.16) Mya set by the age of the oldest solid material in the Solar System found in some meteorites about 4.567 billion years old. The proposed interplanetary collision that created the Moon occurred early in this eon, and the Late Heavy Bombardment is hypothesized to have occurred at the end of the eon.
PolynucleotideIn molecular biology, a polynucleotide () is a biopolymer composed of 13 nucleotide monomers, covalently bonded in a chain. DNA (deoxyribonuc and RNA (ribonucleic acid) are examples of polynucleotides with distinct Although DNA and RNA do not generally occur in the same polynucleotide, the four species of nucleotides may occur in any order in the chain. The sequence of DNA or RNA species for a given polynucleotide is the main factor determining its function in a living organism or a scientific experiment.
