Discusses personalized health through the perspective of a fly as a model organism, exploring reductionism, holism, systems medicine, symbiosis, and the microbiota in 4Ps Medicine.
Explores the selection and rationale behind preclinical animal models in drug discovery, emphasizing understanding mechanisms of action and domain specificity.
Explores the selection and rationale of preclinical animal models in drug development, emphasizing the 10 to 15-year path to a marketed small-molecule drug.
Explores telomere syndromes, telomerase expression, end replication problems, telomere length during aging, defects in telomerase genes, and mouse models.
Explores the design of a general-purpose distributed execution system, covering challenges, specialized frameworks, decentralized control logic, and high-performance shuffle.
Explores organoids, miniature tissue constructs mimicking living tissues, covering derivation methods, applications, and bridging in vitro and in vivo models.
