Publications related to Structural anthropology

Microscopic picture of paraelectric perovskites from structural prototypes

Nicola Marzari, Giovanni Pizzi, Michele Kotiuga, Boris Kozinsky

We highlight with first-principles molecular dynamics the persistence of intrinsic < 111 > Ti off-centerings for BaTiO3 in its cubic paraelectric phase. Intriguingly, these are inconsistent with the Pm (3) over barm space group often used to atomistically ...

AMER PHYSICAL SOC2022

Structural basis of drug recognition by the multidrug transporter ABCG2

Henning Paul-Julius Stahlberg, Dongchun Ni

ABCG2 is an ATP-binding cassette (ABC) transporter whose function affects the pharmacokinetics of drugs and contributes to multidrug resistance of cancer cells. While its interaction with the endogenous substrate estrone-3-sulfate (E1S) has been elucidated ...

Elsevier2021

Bridge enhancement by means of the UHPFRC Technology: concepts and recent applications

Eugen Brühwiler

Existing bridges in reinforced concrete (RC) need to be enhanced in order to comply with utilization and safety requirements of future use, in particular for higher traffic loads. Such enhancements comprise strengthening to increase the structural resistan ...

Taylor & Francis2021

Sustainability through reuse: a reconfigurable structural system for residential and office buildings

Corentin Jean Dominique Fivet, Jan Friedrich Georg Brütting, Dario Redaelli, Alex-Manuel Muresan

Current load-bearing systems for buildings rarely have a beneficial end of life. Modular design is a proven solution for revalorizing obsolete structures, but it hardly competes with conventional solutions: the range of future spatial configurations that t ...

World Sustainable Built Environment2020

A Structural Design Methodology for Freeform Timber Plate Structures Using Wood-Wood Connections

Anh Chi Nguyen

Over the past decades, timber has gained popularity as a sustainable building material because of the rising environmental awareness. Furthermore, the resurgence of timber has also been encouraged by the advent of the digital age during the 21st century. T ...

EPFL2020

Post-synthesis deposition of mesoporous niobic acid with improved thermal stability by kinetically controlled sol–gel overcoating

Jeremy Luterbacher, Florent Emmanuel Héroguel, Yuan-Peng Du

Niobia is a well-known solid acid catalyst owing to its intrinsic Brønsted and Lewis acidity. However, catalyst development with this oxide has been limited by our ability to control its pore structure and thermal stability. Here we report a novel post-syn ...

Royal Society of Chemistry2019

Atomistic Simulations of The Structure of Calcium Silicate Hydrates: Interlayer Positions, Water Content And A General Structural Brick Model

Aslam Kunhi Mohamed

Portland cement has been in use by human civilization for over a century. Yet, we do not fully understand its hydration reaction mechanisms due to the complexity of the system and its continued reaction over time making it hard to study it experimentally. ...

EPFL2018

DNP in Materials Science: Touching the Surface

David Lyndon Emsley, Pierrick Berruyer

Dynamic nuclear polarization (DNP)-enhanced solid-state NMR spectroscopy under magic-angle spinning has recently emerged as a unique analytical method to probe surfaces at atomic resolution. In this article, we first describe the basic principles of dynami ...

WILEY2018

Nanoscale studies link amyloid maturity with polyglutamine diseases onset

Giovanni Dietler, Hilal Lashuel, Giovanni Longo, Francesco Simone Ruggeri, Urszula Beata Cendrowska

The presence of expanded poly-glutamine (polyQ) repeats in proteins is directly linked to the pathogenesis of several neurodegenerative diseases, including Huntington's disease. However, the molecular and structural basis underlying the increased toxicity ...

Nature Research2016

The mechanisms of spatial and temporal patterning of cell-edge dynamics

Alexander Verkhovskiy

Adherent cells migrate and change their shape by means of protrusion and retraction at their edges. When and where these activities occur defines the shape of the cell and the way it moves. Despite a great deal of knowledge about the structural organizatio ...

Elsevier2015

Utility-Based Mechanism for Structural Self-Organization in Service-Oriented MAS

Matteo Vasirani

Structural relations established among agents influence the performance of decentralized service discovery process in multiagent systems. Moreover, distributed systems should be able to adapt their structural relations to changes in environmental condition ...

Assoc Computing Machinery2014

Application of hybrid glass-timber elements in architecture

Pieter Christian Louter, Manuel Santarsiero, Paul Ehret, Philipp Eversmann

The following paper explores the application of hybrid timber-glass elements on semi-continuous architectural structures. The use of glass as a structural material opens multiple fields of investigations. Beyond structural matters and safety issues, archit ...

2014

Development of New Bicyclic Peptide Formats and their Application in Directed Evolution

Shiyu Chen

Cyclic peptides have a range of properties that make them attractive as therapeutics such as high binding affinity, good target selectivity and low toxicity. While most peptides in the clinic are derived from nature, various powerful in vitro evolution tec ...

EPFL2013

Caenorhabditis elegans centriolar protein SAS-6 forms a spiral that is consistent with imparting a ninefold symmetry

Pierre Gönczy, Virginie Hamel, Georgios Hatzopoulos, Paul Guichard, Isabelle Fluckiger

Centrioles are evolutionary conserved organelles that give rise to cilia and flagella as well as centrosomes. Centrioles display a characteristic ninefold symmetry imposed by the spindle assembly abnormal protein 6 (SAS-6) family. SAS-6 from Chlamydomonas ...

2013

Structurally Diverse Cyclisation Linkers Impose Different Backbone Conformations in Bicyclic Peptides

Christian Heinis, Alessandro Angelini, Shiyu Chen, Julia Morales Sanfrutos

Combinatorial libraries of structurally diverse peptide macrocycles offer a rich source for the development of high-affinity ligands to targets of interest. In this work we have developed linkers for the generation of genetically encoded bicyclic peptides ...

2012

Structural Studies and Protein Engineering of Human O6-Alkylguanine-DNA Alkyltransferase

Birgit Mollwitz

The specific labeling of proteins with synthetic probes is a powerful approach to study protein function and protein tags have been widely used for this purpose. A well-established example for a self-labeling protein tag is SNAP-tag. It specifically reacts ...

EPFL2012

Structural Preferences of Gas-Phase M2TMP Monomers upon Sequence Variations

Yury Tsybin, Hisham Ben Hamidane, Rodolphe Antoine

The conformations of a number of M2TMP-(22-46) sequence variants have been investigated using ion mobility spectrometry (IMS). Substantial conformational changes were evidenced by IMS upon the variation of a single amino acid in the peptide sequence, with ...

2011

Anguinomycins and Derivatives: Total Syntheses, Modeling, and Biological Evaluation of the Inhibition of Nucleocytoplasmic Transport

Karl Gademann, Simone Bonazzi, Jean-Yves Wach, Ivo Zemp

The preparation of the polyketide natural products anguinomycin C and D is reported based on key steps such as Negishi stereoinversion cross coupling, Jacobsen Cr(III)-catalyzed Hetero Diels−Alder reaction, Evans B-mediated syn-aldol chemistry, and B-alkyl ...

2010

Synthesis, Biological Evaluation and Docking Studies of Casuarine Analogues: Effects of Structural Modifications at Ring B on Inhibitory Activity Towards Glucoamylase

Pierre Vogel, Claudia Bello

We report the total synthesis of a series of pyrrolizidine analogues of casuarine (1) and their 6-O-alpha-glucoside derivatives. The synthetic strategy is based on a totally regio- and stereoselective 1,3-dipolar cycloaddition of suitably substituted alken ...

2010

Preparation and characterization of toxic Abeta aggregates for structural and functional studies in Alzheimer's disease research

Hilal Lashuel, Mohammad Asad Jan Qureshi

The amyloid cascade hypothesis, supported by strong evidence from genetics, pathology and studies using animal models, implicates amyloid-beta (Abeta) oligomerization and fibrillogenesis as central causative events in the pathogenesis of Alzheimer's diseas ...

Nature Publishing Group2010