Publications related to Obsessive–compulsive disorder

Functional MRI Neurofeedback Outperforms Cognitive Behavioral Therapy for Reducing Tinnitus Distress: A Prospective Randomized Clinical Trial

Dimitri Nestor Alice Van De Ville, Nicolas Gninenko

Background: Cognitive behavioral therapy (CBT) is the current standard treatment for chronic severe tinnitus; however, preliminary evidence suggests that real-time functional MRI (fMRI) neurofeedback therapy may be more effective. Purpose: To compare the e ...

Radiological Soc North America (Rsna)2024

Surgical approaches to the capitellum: a comparative anatomic study

Alexandre Terrier, Patrick Goetti, Frédéric Vauclair

Background: Osteochondritis dissecans (OCD) of the humeral capitellum is an important cause of elbow disability in young athletes. Large and unstable lesions sometimes require joint reconstruction with osteochondral autograft. Several approaches have been ...

Mosby-Elsevier2024

A 16-Channel Low-Power Neural Connectivity Extraction and Phase-Locked Deep Brain Stimulation SoC

Mahsa Shoaran, Uisub Shin, Cong Ding

Growing evidence suggests that phase-locked deep brain stimulation (DBS) can effectively regulate abnormal brain connectivity in neurological and psychiatric disorders. This letter therefore presents a low-power SoC with both neural connectivity extraction ...

IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC2023

Neural Basis of Internal Attention in Adults with Pure and Comorbid ADHD

Farnaz Delavari, Halima Rafi

Objective: To examine whether putatively atypical neuronal activity during internal attention in ADHD yields insights into processes underlying emotion dysregulation. Methods: We used a word processing paradigm to assess neural activations in adults with A ...

2023

Glucocorticoid-based pharmacotherapies preventing PTSD

Maria del Carmen Sandi Perez, Silvia Monari

Posttraumatic stress disorder (PTSD) is a highly disabling psychiatric condition that may arise after exposure to acute and severe trauma. It is a highly prevalent mental disorder worldwide, and the current treatment options for these patients remain limit ...

2023

'connEcted caesarean section': creating a virtual link between MOthers and their infanTs to ImprOve maternal childbirth experieNce - study protocol for a PILOT trial (e-motion-pilot)

Sandra Maria Marcadent, David Desseauve, Karine Lepigeon, Fiona Corbaz

IntroductionOne-third of mothers rate their childbirth as traumatic. The prevalence of childbirth-related post-traumatic stress disorder (CB-PTSD) is 4.7%. Skin-to-skin contact is a protective factor against CB-PTSD. However, during a caesarean section (CS ...

BMJ PUBLISHING GROUP2023

Development of stimuli-responsive chemistry for tumor-targeted immunotherapy

Céline Jasmin Prange

Cancer immunotherapy is the science of boosting the immune response of patients to fight cancer. Recent advances have brought up treatments with huge success in the clinic. Patients with ad-vanced-stage cancers were long-term cured through checkpoint inhib ...

EPFL2023

Identifying Disease-Specific Neural Reactivity to Psychosocial Stress in Borderline Personality Disorder

Dimitri Nestor Alice Van De Ville

BACKGROUND: Patients with borderline personality disorder (BPD) typically present emotion dysregulation (ED) when faced with adversity. However, it is argued that altered stress response may be more influenced by ED than BPD-specific traits. Here, we inves ...

ELSEVIER2022

Sex Differences in Comorbidity Combinations in the Swedish Population

Patrick Karl Alois Neff

High comorbidity rates, especially mental-physical comorbidity, constitute an increasing health care burden, with women and men being differentially affected. To gain an overview of comorbidity rates stratified by sex across a range of different conditions ...

MDPI2022

Many-body localization in a fragmented Hilbert space

Loïc Jean Pierre Herviou

We study many-body localization (MBL) in a pair-hopping model exhibiting strong fragmentation of the Hilbert space. We show that several Krylov subspaces have both ergodic statistics in the thermodynamic limit and a dimension that scales much slower than t ...

2021

An overlapping pattern of cerebral cortical thinning is associated with both positive symptoms and aggression in schizophrenia via the ENIGMA consortium

Erick Jorge Canales Rodriguez, Wenhao Jiang

Background Positive symptoms are a useful predictor of aggression in schizophrenia. Although a similar pattern of abnormal brain structures related to both positive symptoms and aggression has been reported, this observation has not yet been confirmed in a ...

2020

Topology predicts long-term functional outcome in early psychosis

Kathryn Hess Bellwald, Martina Scolamiero, Kim Do

Early intervention in psychosis is crucial to improving patient response to treatment and the functional deficits that critically affect their long-term quality of life. Stratification tools are needed to personalize functional deficit prevention strategie ...

2021

Triple Network Model Dynamically Revisited: Lower Salience Network State Switching in Pre-psychosis

Dimitri Nestor Alice Van De Ville, Thomas William Arthur Bolton

Emerging evidence has attributed altered network coordination between the default mode, central executive, and salience networks (DMN/CEN/SAL) to disturbances seen in schizophrenia, but little is known for at-risk psychosis stages. Moreover, pinpointing im ...

2020

Anderson localisation in steady states of microcavity polaritons

Daniel Oberli, Marcia Portella Oberli, Mitchell David Anderson, Fauzia Jabeen, Morteza Navadeh Toupchi, Albert Adiyatullin

We present an experimental signature of the Anderson localisation of microcavity polaritons, and provide a systematic study of the dependence on disorder strength. We reveal a controllable degree of localisation, as characterised by the inverse-participati ...

Springer Nature2019

Frontal cortical thickness correlates positively with impulsivity in early psychosis male patients

Alessandra Griffa, Kim Do

Aim Impulsive behaviours, which are frequent in young people suffering from psychosis have been linked to risky and violent behaviours and participate to the burden of psychotic illness. Given that morphological brain correlates of impulsivity in schizophr ...

WILEY2019

Spatial control of heavy-fermion superconductivity in CeIrIn5

Philip Johannes Walter Moll, Matthias Carsten Putzke, Maja Deborah Bachmann, Kent Robert Shirer

Although crystals of strongly correlated metals exhibit a diverse set of electronic ground states, few approaches exist for spatially modulating their properties. In this study, we demonstrate disorder-free control, on the micrometer scale, over the superc ...

American Association for the Advancement of Science2019

Trait anxiety on effort allocation to monetary incentives: a behavioral and high-density EEG study

Maria del Carmen Sandi Perez, João Pedro de Matos Rodrigues, Alina Veronika Irene Strasser

Trait anxiety is an important phenotype in the prediction of stress-induced neuropsychiatric disorders. While the role of trait anxiety in mental effort and cognitive impairment is well documented, much less is known about its influence on motivated behavi ...

2019

Reactivation of Recall-Induced Neurons in the Infralimbic Cortex and the Basolateral Amygdala After Remote Fear Memory Attenuation

Johannes Gräff, Ossama Mohamed Salah El-Dien El-Sayed Ibrahim Khalaf

Whether the attenuation of traumatic memories is mediated through the suppression of the original memory trace of fear by a new memory trace of safety, or through an updating of the original fear trace towards safety has been a long-standing question at th ...

2019

System Design and Advanced Circuit Techniques for Bi-Directional Brain-Machine Interfaces

Wen-Yang Hsu

Bi-directional brain-machine interfaces (BBMIs) that can capture electrophysiological signals and provide feedback through electrical stimulation are emerging tools with various applica-tions in fundamental neuroscience research as well as in clinical trea ...

EPFL2018

In the pursuit of the fear engram: identification of neuronal circuits underlying the treatment of anxiety disorder

Ossama Mohamed Salah El-Dien El-Sayed Ibrahim Khalaf

Fear and other anxiety disorders are extraordinarily robust and difficult to treat. Among the most effective treatments for anxiety disorders are exposure-based therapies, during which a patient is repeatedly confronted with the originally fear-eliciting s ...

EPFL2017