Publications related to Medical physics

Characterization of a flexible a-Si:H detector for in vivo dosimetry in therapeutic x-ray beams

Sylvain Dunand, Nicolas Würsch, Luca Massimiliano Antognini, Jonathan Emanuel Thomet, Matthew James Large

BackgroundThe increasing use of complex and high dose-rate treatments in radiation therapy necessitates advanced detectors to provide accurate dosimetry. Rather than relying on pre-treatment quality assurance (QA) measurements alone, many countries are now ...

Wiley2024

Hydrogenated amorphous silicon high flux x-ray detectors for synchrotron microbeam radiation therapy

Sylvain Dunand, Nicolas Würsch, Matthew James Large, Giulia Rossi

Objective. Microbeam radiation therapy (MRT) is an alternative emerging radiotherapy treatment modality which has demonstrated effective radioresistant tumour control while sparing surrounding healthy tissue in preclinical trials. This apparent selectivity ...

IOP Publishing Ltd2023

Satellite-Based Personal UV Dose Estimation

Athanasios Nenes, David Vernez

Epidemiology and public health research relating to solar ultraviolet (UV) exposure usually relies on dosimetry to measure UV doses received by individuals. However, measurement errors affect each dosimetry measurement by unknown amounts, complicating the ...

2021

Superparamagnetic nanohybrids with cross-linked polymers providing higher in vitro stability

Heinrich Hofmann, Lionel André Maurizi

A simple, rapid, reproducible, and scalable method for generating highly stable cross-linked superparamagnetic nanohybrids was developed. Pre-coating of superparamagnetic iron oxide nanoparticle surfaces with a biocompatible polymer, hydroxy polyvinyl alco ...

Springer Verlag2017

Challenges and Opportunities in the Development of Organometallic Anticancer Drugs

Paul Joseph Dyson, Christian Hartinger

This review provides an introduction into the fascinating area of organometallic anticancer compounds. Although the subject dates back many years, it has witnessed considerable growth only in the past decade. A brief overview of the subject together with r ...

Amer Chemical Soc2012

Mass Flows of X-ray Contrast Media and Cytostatics in Hospital Wastewater

David Gregory Weissbrodt, Juliane Hollender, Hansruedi Siegrist

Little is known about the significance of hospitals as point sources for emission of organic micropollutants into the aquatic environment. A mass flow analysis of pharmaceuticals and diagnostics used in hospitals was performed on the site of a representati ...

2009

Breast texture synthesis and estimation of the role of the anatomy and tumor shape in the radiological detection process : from digital mammography to breast tomosynthesis

Cyril Castella

Breast cancer is the most common, and the number one cause of death by cancer among women. However, when it is sufficiently early detected, heavy treatments can be avoided, and morbidity and mortality can be reduced. This is the reason why randomized clini ...

EPFL2009

Experimental Characterization of Pressure Wave Generation and Propagation in Biological Tissues

Kossi Agbeviade, Jacques Giovanola, Mathieu Benoit, Marcel Donnet

Aim of the study: This work develops a measurement technique for pressure waves in soft tissues. It aims at characterizing, understanding and modeling the generation and propagation of pressure waves in soft tissues, with a view towards medical application ...

Springer, 233 Spring Street, New York, Ny 10013, United States2009

Dense deformation field estimation for atlas registration using the active contour framework

Valérie Duay

A key research area in computer vision is image segmentation. Image segmentation aims at extracting objects of interest in images or video sequences. These objects contain relevant information for a given application. For example, a video surveillance appl ...

EPFL2008

Nonrigid medical image registration : algorithms, validation and applications

Francisco Javier Sanchez Castro

Over the last two decades medical image processing has become a fundamental tool in medicine, and brain imaging is a paradigm thereof. The fast development of the imaging acquisition techniques allows medical staff to dispose of a variety of data coming fr ...

EPFL2008

A 130nm CMOS Single Photon Avalanche Diode

Edoardo Charbon, Cristiano Niclass, Marek Gersbach

The first implementation of a single photon avalanche diode (SPAD) is reported in 130nm CMOS technology. The SPAD is fabricated as p+/nwell junction with octagonal shape. Premature edge breakdown is prevented through a guard ring of p-well around the p+ an ...

2007

A Single Photon Avalanche Diode Implemented in 130nm CMOS Technology

Edoardo Charbon, Cristiano Niclass, Marek Gersbach

We report on the ﬁrst implementation of a single photon avalanche diode (SPAD) in 130 nm complementary metal–oxide–semiconductor (CMOS) technology. The SPAD is fabricated as p+/n-well junction with octagonal shape. A guard ring of p-well around the p+ anod ...

2007

Novel chelators for MRI applications : stability and relaxation properties of their metal complexes

In the last two decades, Magnetic Resonance Imaging (MRI) has evolved into one of the most powerful techniques in diagnostic clinical medicine and biomedical research. MRI is primarily used to produce anatomical images, but may also give information on the ...

EPFL2006

Surface extraction and flattening for anatomical visualization

Laurent Saroul

In the last years, three-dimensional (3D) medical imaging techniques have taken an increasing importance in patient care and medical research. Volume images provide medical specialists with a direct access to the interior of a patient's body and reduce the ...

EPFL2006

Spectroscopic infrared near-field microscopy and x-ray reflectivity studies of order and clustering in lipid membranes

Giorgio Margaritondo, Johanna Generosi

Lipid membranes were studied by infrared scanning near-field optical microscopy at several wavelengths and by x-ray reflectivity. Together with the x-ray data, the optical images indicate the formation of locally ordered multiple bilayers, and the topograp ...

AIP American Institute of Physics2006

Validation of Experts Versus Atlas-Based and Automatic Registration Methods for Subthalamic Nucleus Targeting on MRI

Jean-Philippe Thiran, Olivier Cuisenaire, Francisco Javier Sanchez Castro

Objects. In functional stereotactic neurosurgery, one of the cornerstones upon which the success and the operating time depends is an accurate targeting. The subthalamic nucleus (STN) is the usual target involved when applying Deep Brain Stimulation (DBS) ...

2006

New strategies for highly efficient medical MRI contrast agents : Gd(III) poly(amino carboxylates) with fast water exchange and Gd(III) trapped in carbon cages

Sabrina Laus

During the last two decades, magnetic resonance imaging (MRI) has evolved into one of the most powerful techniques in medical diagnosis. Among the various medical diagnostic modalities, such as X-ray or ultra-sound imaging, MRI is the technique of choice e ...

EPFL2005

Light dosimetry for photodynamic therapy in the esophagus

Hubert van den Bergh, Georges Wagnières

BACKGROUND AND OBJECTIVE: Photodynamic therapy (PDT) is an efficient technique to treat superficial early cancers in the pharynx, esophagus, and tracheo-bronchial tree. However, the lack of selectivity of some of the clinically used photosensitizers can re ...

1997

Endoscopic holography with a muticore optical fiber applied to biomedical imaging

An in situ holographic technique based on the use of a flexible miniaturized endoscope (diameter less than 1 mm) was developed for medical applications. The holographic system features a multicore optical fiber (MCF) coupled to a CCD camera to record the h ...

EPFL1994