Polycystic kidney disease

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Related publications (26)

Two mutations in human BICC1 resulting in Wnt pathway hyperactivity associated with cystic renal dysplasia

Daniel Constam, Anne Grapin-Botton, Marine Marie Kraus

Bicaudal C homologue 1 (Bicc1) knockout in mice causes polycystic kidney disease and pancreas development defects, including a reduction in insulin-producing β-cells and ensuing diabetes. We therefore screened 137 patients with renal abnormalities or assoc ...

2011

Finite element simulations of kidney stones fragmentation by direct impact: Tool geometry and multiple impacts

Jean-François Molinari

This paper analyses the fragmentation of kidney stones by direct impact with Swiss Lithoclast Master(R). Based on a previous work, the impact of the probe of the Lithoclast is modeled with a displacement control of the nodes inside the impacted area. Diffe ...

Elsevier2010

Role of Bicaudal-C in Left-Right Axis Formation and Kidney Morphogenesis

Charlotte Maisonneuve

The KH domain RNA binding protein Bicaudal-C is known to play a role in anterior-posterior (AP) patterning in Drosophila by acting on oskar mRNA. In mammals, its expression is induced at late gastrulation in the mesodermal layer of the ventral node. Renal ...

EPFL2010

Wnt Signaling in Pancreas Development and Cancer

Marine Marie Kraus

During early somite stages of development, the broad endoderm-derived foregut and hindgut territories become further subdivided along the antero-posterior axis into organs. One of these organs is the pancreas which serves two major physiological functions: ...

EPFL2010

Transgenic mice and their impact on kidney research

Friedrich Beermann

The kidney is a key organ in the maintenance of ion and fluid homeostasis and specific transport systems localized along the nephron guarantee this function. Due to its large functional heterogeneity, experiments on the whole organ level cannot be easily p ...

2009

Bicaudal C, a novel regulator of Dvl signaling abutting RNA-processing bodies, controls cilia orientation and leftward flow

Daniel Constam, Thomas Alois Weber, Charlotte Maisonneuve

Polycystic diseases and left-right (LR) axis malformations are frequently linked to cilia defects. Renal cysts also arise in mice and frogs lacking Bicaudal C (BicC), a conserved RNA-binding protein containing K-homology (KH) domains and a sterile alpha mo ...

2009

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