Publications related to Early intervention in psychosis

Neurocognition and NMDAR co-agonists pathways in individuals with treatment resistant first-episode psychosis: a 3-year follow-up longitudinal study

This study aims to determine whether 1) individuals with treatment-resistant schizophrenia display early cognitive impairment compared to treatment-responders and healthy controls and 2) N-methyl-D-aspartate-receptor hypofunction is an underlying mechanism ...

Springernature2024

Transdiagnostic markers across the psychosis continuum: a systematic review and meta-analysis of resting state fMRI studies

Dimitri Nestor Alice Van De Ville, Farnaz Delavari

Psychotic symptoms are among the most debilitating and challenging presentations of severe psychiatric diseases, such as schizophrenia, schizoaffective, and bipolar disorder. A pathophysiological understanding of intrinsic brain activity underlying psychos ...

Frontiers Media Sa2024

Exploring associations between diurnal cortisol, stress, coping and psychopathology in adolescents and young adults with 22q11.2 deletion syndrome

Maria del Carmen Sandi Perez, Olivia Zanoletti, Maude Schneider, Farnaz Delavari

Background: 22q11.2 deletion syndrome (22q11DS) is a neurogenetic condition associated to a high risk for psychiatric disorders, including psychosis. Individuals with 22q11DS are thought to experience increased levels of chronic stress, which could lead to ...

2022

The shine-through paradigm and the schizophrenia spectrum: a summary

Michael Herzog, Simona Adele Garobbio, Maya Roinishvili, Ophélie Gladys Favrod, Janir Nuno Ramos Antunes Da Cruz

In the past 10 years, our laboratory has proved the shine-through paradigm to be a very sensitive endophenotype for schizophrenia. The shine-through paradigm is a visual backward masking task, where the target is a vertical vernier followed by a 25-element ...

2021

Sensorimotor Induction of Auditory Misattribution in Early Psychosis

Olaf Blanke, Alessandra Griffa, Fosco Bernasconi, Andrea Serino, Kim Do, Roy Salomon, Patric Hagmann, Giulio Rognini, Silvia Marchesotti, Pierre Progin

Dysfunction of sensorimotor predictive processing is thought to underlie abnormalities in self-monitoring producing passivity symptoms in psychosis. Experimentally induced sensorimotor conflict can produce a failure in bodily self-monitoring (presence hall ...

2020

Partial-volume modeling reveals reduced gray matter in specific thalamic nuclei early in the time course of psychosis and chronic schizophrenia

Meritxell Bach Cuadra, Patric Hagmann, Kim Do, Erick Jorge Canales Rodriguez, Mario Joao Fartaria de Oliveira, Elena Najdenovska, Zita Rovó

The structural complexity of the thalamus, due to its mixed composition of gray and white matter, make it challenging to disjoint and quantify each tissue contribution to the thalamic anatomy. This work promotes the use of partial-volume-based over probabi ...

Wiley2020

Unraveling neural and behavioral mechanisms of cognitive self-attenuation and alienation

Giedre Stripeikyte

The present thesis aimed at investigating behavioral and neural underpinnings of the mechanisms related to the different aspects of self-monitoring. The first aim was to study functional connectivity alterations related to the mechanisms accounting for the ...

EPFL2020

Hallucination Engineering: From Neuroscience Robotics to Hallucinations in Health and Disease

Eva Blondiaux

My thesis focuses on a psychotic symptom called the presence hallucination (PH). PHs are defined as the false perception that someone is nearby when no one is actually present. PHs can occur in various populations, ranging from healthy subjects (when expos ...

EPFL2020

MMP9/RAGE pathway overactivation mediates redox dysregulation and neuroinflammation, leading to inhibitory/excitatory imbalance: a reverse translation study in schizophrenia patients

Lijing Xin, Kim Do, Daniella Dwir, Basilio Giangreco

ious mechanisms involved in schizophrenia pathophysiology, such as dopamine dysregulation, glutamate/NMDA receptor dysfunction, neuroinflammation or redox imbalance, all appear to converge towards an oxidative stress "hub" affecting parvalbumine interneuro ...

2020

Electrophysiological correlates of visual backward masking in the schizophrenia continuum

Ophélie Gladys Favrod

In visual backward masking (VBM), a target is followed by a mask. Over the past decade, a VBM task, called the Shine-Through paradigm (ST), has been shown to be a very sensitive endophenotype of schizophrenia. In the present thesis, the electrophysiologica ...

EPFL2019

N-acetylcysteine add-on treatment leads to an improvement of fornix white matter integrity in early psychosis: a double-blind randomized placebo-controlled trial

Rolf Gruetter, Lijing Xin, Alessandra Griffa, Kim Do, Patric Hagmann

Mechanism-based treatments for schizophrenia are needed, and increasing evidence suggests that oxidative stress may be a target. Previous research has shown that N-acetylcysteine (NAC), an antioxidant and glutathione (GSH) precursor almost devoid of side e ...

2018

Cortical morphology development in patients with 22q11.2 deletion syndrome at ultra-high risk of psychosis

Maude Schneider, Marie Schaer, Daniela Maria Zöller, Maria Carmela Padula

Background. Patients with 22q11.2 deletion syndrome (22q11DS) present a high risk of developing psychosis. While clinical and cognitive predictors for the conversion towards a full-blown psychotic disorder are well defined and largely used in practice, neu ...

CAMBRIDGE UNIV PRESS2018

Visual masking and schizophrenia: enhancement deficit 200 ms after stimulus onset

Michael Herzog, Ophélie Gladys Favrod, Maya Roinishvili, Janir Nuno Ramos Antunes Da Cruz

Masking is strongly deteriorated in schizophrenia patients and to a lesser extent in their healthy relatives. For this reason, masking is a good endophenotype. Here, we show the EEG correlates of masking across the schizophrenia continuum in order to tackl ...

2018

Cannabis use in early psychosis is associated with reduced glutamate levels in the prefrontal cortex

Rolf Gruetter, Lijing Xin, Kim Do

Recent studies have shown that cannabis may disrupt glutamate (Glu) signaling depressing Glu tone in frequent users. Current evidence have also consistently reported lower Glu-levels in various brain regions, particularly in the medial prefrontal cortex (m ...

Springer Verlag2018

Neural correlates of visual backward masking in psychosis

Michael Herzog, Ophélie Gladys Favrod, Christine Mohr, Maya Roinishvili, Janir Nuno Ramos Antunes Da Cruz, Albulena Jashari-Shaqiri

In visual backward masking (VBM), a target is followed by a mask, which deteriorates performance on the target. Schizophrenia and first episodes patients show strong behavioral deficits, reflected in strongly reduced amplitudes of the EEG as compared to co ...

2017

Electrophysiological correlates of visual backward masking in first-episode psychosis

Michael Herzog, Maya Roinishvili, Ophélie Gladys Favrod, Janir Nuno Ramos Antunes Da Cruz, Albulena Jashari-Shaqiri

Schizophrenia is a heterogeneous disorder and among other symptoms, patients have important visual impairments. Visual paradigms are therefore important tools to investigate the mechanisms of schizophrenia. We have previously shown that visual backward mas ...

2017

Visual backward masking and the schizophrenia spectrum: EEG correlates

Michael Herzog, Maya Roinishvili, Ophélie Gladys Favrod, Janir Nuno Ramos Antunes Da Cruz, Albulena Jashari-Shaqiri

Schizophrenia is a heterogeneous disease strongly influenced by genetic factors. We have previously shown that visual backward masking (VBM) is a very sensitive endophenotype of schizophrenia (Chkonia et al., 2010). Importantly, not only patients but also ...

2017

Glutathione deficit impairs myelin maturation: relevance for white matter integrity in schizophrenia patients

Jean-Philippe Thiran, Rolf Gruetter, Lijing Xin, Alessandra Griffa, Kim Do, Aline Monin, Patric Hagmann, Philipp Baumann

Schizophrenia pathophysiology implies both abnormal redox control and dysconnectivity of the prefrontal cortex, partly related to oligodendrocyte and myelin impairments. As oligodendrocytes are highly vulnerable to altered redox state, we investigated the ...

Nature Publishing Group2015

The longitudinal association between social functioning and theory of mind in first-episode psychosis

Christine Mohr, Daniela Herzig

IntroductionThere is some cross-sectional evidence that theory of mind ability is associated with social functioning in those with psychosis but the direction of this relationship is unknown. This study investigates the longitudinal association between bot ...

Taylor & Francis2014

Reduced Fronto-Temporal and Limbic Connectivity in the 22q11.2 Deletion Syndrome: Vulnerability Markers for Developing Schizophrenia?

Jean-Philippe Thiran, Marie Schaer, Leila Cammoun

The 22q11.2 deletion syndrome (22q11DS) is a widely recognized genetic model allowing the study of neuroanatomicalvbiomarkers that underlie the risk for developing schizophrenia. Recent advances in magnetic resonance image analysesvenable the examination o ...

Public Library of Science2013