Publications related to Environmental impact of pharmaceuticals and personal care products

Electrochemical determination of nicotine in smokers' sweat

In this work, we report the demonstration of the capability of electrochemical sensors to provide measurements directly on the sweat of volunteers to successfully discriminate heavy smokers by light ones. Since its importance as pharmaceutical treatment-ag ...

ELSEVIER2020

Advancing Drug Discovery via Artificial Intelligence

Horst Vogel, Shuguang Yuan, Thamani Dahoun

Drug discovery and development are among the most important translational science activities that contribute to human health and wellbeing. However, the development of a new drug is a very complex, expensive, and long process which typically costs 2.6 bill ...

ELSEVIER SCIENCE LONDON2019

Microdevice-integrated immunoassays for Point-of-Care Therapeutic Drug Monitoring

Elena-Diana Bojescu

A significant number of drugs exhibit narrow therapeutic windows and high inter-individual pharmacokinetic variability. In such cases, Therapeutic Drug Monitoring (TDM) is compulsory in order to optimize the efficacy of the drug while avoiding adverse effe ...

EPFL2018

TUCUXI: TUCUXI: An Intelligent System for Personalized Medicine from Individualization of Treatments to Research Databases and Back

Karl Aberer, Alevtina Dubovitskaya, Yann Thoma, Michael Ignaz Schumacher, Thierry Buclin

Therapeutic Drug Monitoring (TDM) is a key concept in precision medicine. The goal of TDM is to avoid therapeutic failure or toxic effects of a drug due to insufficient or excessive circulating concentration exposure related to between-patient variability ...

2017

Bioluminescent sensor proteins for point-of-care therapeutic drug monitoring

Rudolf Griss

To ensure efficacy but avoid toxicity, many drugs require monitoring of their concentrations in the patient’s blood during therapy. Currently, therapeutic drug monitoring (TDM) is done in diagnostic laboratories that need trained personnel and expensive in ...

EPFL2013

Substance flow analysis as a tool for mitigating the impact of pharmaceuticals on the aquatic system

Luca Rossi, Sylvain Coutu, Jonas Margot, Htet Kyi Wynn

Pharmaceuticals constitute an important environmental issue for receiving waters. A holistic approach, taking into consideration the sources of these compounds (hospitals, domestic use), discharges (wastewater effluent, combined sewer overflows) and relate ...

Elsevier2013

Pharmaceuticals and their human metabolites in Lake Geneva: occurrence, fate and ecotoxicological relevance

Tamar Kohn, Florence Bonvin, Rebecca Rutler

This study assesses the presence, fate and effects of five environmentally relevant pharmaceuticals and eight of their corresponding human metabolites in Lake Geneva. Over a 10-month period, lake samples were taken at various depths and locations in the Vi ...

2012

Spatial and temporal presence of a wastewater-derived micropollutant plume in Lake Geneva

Tamar Kohn, Florence Bonvin, Rebecca Rutler

This study discusses the occurrence and environmental risk associated with a micropollutant plume originating from the direct discharge of treated wastewater into the Vidy Bay of Lake Geneva, Switzerland. The temporal variations and spatial extent of the p ...

2011

Removal of pharmaceuticals from water: Using liquid-core microcapsules as a novel approach

Urs von Stockar, Ian William Marison

In recent years ever-increasing amounts of pharmaceuticals are being detected in the aquatic environment and in some cases, they have even been discovered in drinking water. Their presence is attributed mainly to the inability of sewage treatment plants to ...

2010

Determining a receptor-ligand interaction useful in e.g. drug screening involves repetitive application of reversibly binding fluorescent ligands with fast association-dissociation kinetics

Horst Vogel, Rudolf Hovius, Jean-Manuel Segura, Marinela Gjoni Boillat, Christoph Schreiter

NOVELTY - Determining a receptor-ligand interaction involves repeatedly contacting a cell comprising a receptor, with a ligand, of the receptor in which the ligand has a fluorescence labeling group and binds reversibly to the receptor under conditions in w ...

2006