Publications related to Periodontology

Bio-Enhanced Neoligaments Graft Bearing FE002 Primary Progenitor Tenocytes: Allogeneic Tissue Engineering & Surgical Proofs-of-Concept for Hand Ligament Regenerative Medicine

Sandra Jaccoud, Corinne Scaletta, Philippe Abdel Sayed, Lee Ann Laurent-Applegate, Nathalie Hirt-Burri, Laurent Alexis Clément Vannay, Cédric Peneveyre, Annick Jeannerat, Alexis Laurent, Joachim Meuli, Axelle Thomas

Hand tendon/ligament structural ruptures (tears, lacerations) often require surgical reconstruction and grafting, for the restauration of finger mechanical functions. Clinical-grade human primary progenitor tenocytes (FE002 cryopreserved progenitor cell so ...

MDPI2023

Viral diversity is linked to bacterial community composition in alpine stream biofilms

Tom Ian Battin, Hannes Markus Peter, Paraskevi Pramateftaki, Meriem Bekliz

Biofilms play pivotal roles in fluvial ecosystems, yet virtually nothing is known about viruses in these communities. Leveraging an optimized sample-to-sequence pipeline, we studied the spatiotemporal turnover of dsDNA viruses associated with stream biofil ...

Springer2022

Structural Basis of Ligand Selectivity by a Bacterial Adhesin Lectin Involved in Multispecies Biofilm Formation

Corey Alfred Stevens

Carbohydrate recognition by lectins governs critical host-microbe interactions. MpPA14 (Marinomonas primoryensis PA14 domain) lectin is a domain of a 1.5-MDa adhesin responsible for a symbiotic bacterium-diatom interaction in Antarctica. Here, we show that ...

Amer Soc Microbiology2021

Atomic Force Microscopy of Biological Systems: Quantitative Imaging and Nanomotion Detection

Petar Stupar

The core of this thesis is the application of different modalities of atomic force microscopy to study living systems. After a brief introduction, quantitative imaging state of the art is presented and the applications for mammalian, plant, bacterial, and ...

EPFL2018

Scaffold requirements for periodontal regeneration with enamel matrix derivative proteins

John Christopher Plummer, Laurent Mirko Dejace, Matteo Gregorio Modesto Marascio, Alessandra Apicella, Peter Fischer

Periodontitis affects the attachment of natural teeth, and infection or inflammation associated with periodontitis may affect peri-implant tissues. Enamel matrix derivative (EMD) proteins provide stimulation for self-regeneration of the damaged tissue when ...

Elsevier Science Bv2017

Dual mobility cups provide biomechanical advantages in situations at risk for dislocation: a finite element analysis

Alexandre Terrier, Adeliya Latypova, Valérie Parvex, Maïka Réane Guillemin

Purpose Constrained devices, standard implants with large heads, and dual mobility systems have become popular options to manage instability after total hip arthroplasty (THA). Clinical results with these options have shown variable success rates and signi ...

Springer Verlag2017

Molecular dynamics simulations of the intrinsically disordered protein amelogenin

John Christopher Plummer, Matteo Gregorio Modesto Marascio, Alessandra Apicella, Vincenzo Colangelo

Amelogenin refers to a class of intrinsically disordered proteins that are the major constituents of enamel matrix derivative (EMD), an extract of porcine fetal teeth used in regenerative periodontal therapy. Modifications in molecular conformation induced ...

Taylor & Francis Inc2017

The Influence of Arginine on the Response of Enamel Matrix Derivative (EMD) Proteins to Thermal Stress: Towards Improving the Stability of EMD-Based Products

John Christopher Plummer, Matteo Gregorio Modesto Marascio, Alessandra Apicella, Raffaele Mezzenga, Peter Fischer

In a current procedure for periodontal tissue regeneration, enamel matrix derivative (EMD), which is the active component, is mixed with a propylene glycol alginate (PGA) gel carrier and applied directly to the periodontal defect. Exposure of EMD to physio ...

Public Library Science2015

Does locally delivered Zoledronate influence peri-implant bone formation? – Spatio-temporal monitoring of bone remodeling in vivo

Dominique Pioletti, Ulrike Kettenberger, Julien Ston

Bisphosphonates are known for their strong inhibitory effect on bone resorption. Their influence on bone formation however is less clear. In this study we investigated the spatio-temporal effect of locally delivered Zoledronate on peri-implant bone formati ...

Elsevier2014

In vivo assessment of local effects after application of bone screws delivering bisphosphonates into a compromised cancellous bone site

Dominique Pioletti, Alireza Roshan Ghias

Background: The primary stability of cancellous screw is difficult to obtain in bone of compromised quality and failure of screw fixation is common. To overcome this problem, it is proposed to locally deliver bisphosphonate from the screw An in vivo valida ...

Elsevier2011

Hydro-mechanical coupling in the periodontal ligament: A porohyperelastic finite element model

John Botsis, Matteo Galli, Joël Cugnoni, Marzio Bergomi

Harmonic tension–compression tests at 0.1, 0.5 and 1 Hz on hydrated bovine periodontal ligament (PDL) were numerically simulated. The process was modeled by finite elements (FE) within the framework of poromechanics, with the objective of isolating the con ...

Elsevier2011

Effect of Micromotion on Morphogen Dynamics in Peri-Implant Healing

Miguel Gortchacow

The primary stability of cementless femoral components is crucial for the long-term success of total hip arthroplasty. We know that the healing phase after surgery is a complex biological process, which is affected by the mechanical environment. Implant lo ...

EPFL2011

Load Response of Periodontal Ligament: Assessment of Fluid Flow, Compressibility, and Effect of Pore Pressure

John Botsis, Marzio Bergomi, Aïssa Mellal

The periodontal ligament (PDL) functions both in tension and in compression. The presence of an extensive vascular network inside the tissue suggests a significant contribution of the fluid phase to the mechanical response. This study examined the load res ...

2010

Three-dimensional morphometry of strained bovine periodontal ligament using synchrotron radiation-based tomography

John Botsis, Joël Cugnoni, Marzio Bergomi, Marco Stampanoni, Philipp Schneider

The periodontal ligament (PDL) is a highly vascularized soft connective tissue. Previous studies suggest that the viscous component of the mechanical response may be explained by the deformation-induced collapse and expansion of internal voids (i.e. chiefl ...

2010

The role of the fluid phase in the viscous response of bovine periodontal ligament

John Botsis, Joël Cugnoni, Marzio Bergomi

The mechanical response of the periodontal ligament (PDL) is complex. This tissue responds as a hyperelastic solid when pulled in tension while demonstrating a viscous behavior under compression. This intricacy is reflected in the tissue's morphology, whic ...

2010

Mechanical response of periodontal ligament: Effects of specimen geometry, preconditioning cycles and time lapse

John Botsis, Marzio Bergomi

This study was conducted as part of research line addressing the mechanical response of periodontal ligament (PDL) to tensile-compressive sinusoidal loading The aim of the present project was to determine the effect of three potential sources of variabilit ...

2009

Regional structural characteristics of bovine periodontal ligament samples and their suitability for biomechanical tests

Marzio Bergomi

Mechanical testing of the periodontal ligament requires a practical experimental model. Bovine teeth are advantageous in terms of size and availability, but information is lacking as to the anatomy and histology of their periodontium. The aim of this study ...

2008

Experimental and numerical investigations on the fluid contribution to the tensile-compressive mechanical behavior of the bovine periodontal ligament

Marzio Bergomi

Orthodontic treatments are all based on the experimental evidence that teeth can be forced to move in the dental arch by means of applied mechanical forces. Since it allows for prediction of dental mobility, the mechanical characterization of the tissues i ...

EPFL2008

Starch-induced implant periapical lesion: A case report

This paper reports an implant periapical lesion (IPL) with a previously unreported etiology. The presence of an osteolytic area around the apex and around the middle portion of a stable Straumann hollow-screw implant was found on periapical radiographs 3.5 ...

2007

With applications to the periodontal ligament: a nonlinear large strain viscoelastic law

Jörn Justiz

The soft tissue, called periodontal ligament (PDL), that connects the alveolar bone and the tooth root accounts to a large extent for the mobility, stress-distribution and, due to its viscoelastic properties, damping of the bone-tooth complex. The accurate ...

EPFL2004