Publications related to Beta-Hydride elimination

Synthetic methodologies for C-C and C-N bond formation involving alkyl radicals

C-C and C-N bonds are some of the most common structures in molecules ranging from drugs to catalysts and to food additives. Many coupling reactions were developed to form these types of bonds with excellent selectivity and good performance. Still, the syn ...

EPFL2020

Functionalization of remote C(sp3)-H bonds enabled by copper-catalyzed coupling of O-acyloximes with terminal alkynes

Qian Wang, Jieping Zhu, Ruben Omar Torres Ochoa, Zhaodong Li

Transition metal catalyzed Sonogashira cross-coupling of terminal alkynes with aryl(vinyl) (pseudo)halides has been successfully extended to alkyl halides for the synthesis of functionalized internal alkynes. The direct alkynylation of remote unfunctionali ...

Nature Research2020

Unexpected Indirect Dynamics in Base-Induced Elimination

Eduardo Carrascosa Casado

Base-induced elimination (E2) and bimolecular nucleophilic substitution (S(N)2) are two of the most versatile reactions that are important in preparative organic chemistry. These stereospecific reactions are often found in direct competition with each othe ...

AMER CHEMICAL SOC2019

Nickel-Catalyzed Regioselective Hydroalkylation and Hydroarylation of Alkenyl Boronic Esters

Xile Hu, Srikrishna Bera

Metal hydride catalyzed hydrocarbonation reactions of alkenes are an efficient approach to construct new carbon-carbon bonds from readily available alkenes. However, the regioselectivity of hydrocarbonation remains challenging to be controlled. In nickel h ...

Wiley-VCH Verlag GmbH2019

A β-Carbon elimination strategy for convenient in situ access to cyclopentadienyl metal complexes

Nicolai Cramer, Matthew Wodrich, Anne-Clémence Corminboeuf, Benoît Daniel Bertrand Audic, Gints Smits

The electronic and steric properties of tailored cyclopentadienyl (Cp) ligands are powerful handles to modulate the catalytic properties of their metal complexes. This requires the individual preparation, purification and storage of each ligand/metal combi ...

2017

Homogenous catalytic hydrogenation of bicarbonate with water soluble aryl phosphine ligands

Paul Joseph Dyson, Gabor Laurenczy, Katerina Stefania Sordakis

The chemical transformation of CO2 and bicarbonates into useful products becomes increasingly impor- tant as the atmospheric CO2 level has reached 400 ppm. Here a small library of sulfonated aryl mono- phosphines and aryl diphosphines was tested as stabili ...

Elsevier2015

Chemoselective Hydrogenation and Transfer Hydrogenation of Aldehydes Catalyzed by Iron(II) PONOP Pincer Complexes

Rosario Scopelliti, Xile Hu, Simona Mazza

Iron-catalyzed hydrogenation has drawn much attention, yet the scope and chemoselectivity of iron catalysis warrant further improvement. Here we report new iron pincer complexes as chemoselective hydrogenation and transfer hydrogenation catalysts. Several ...

American Chemical Society2015

A Well-Defined Ni Pincer Catalyst for Cross Coupling of Non-Activated Alkyl Halides and Direct C-H Alkylation

Oleg Vechorkin

Carbon-carbon bond forming reactions are among the most important and useful methods for organic synthesis. During the last years, significant progress has been made in this field. Whereas many catalysts were developed for the coupling of aryl, alkenyl, an ...

EPFL2011

Organometallic ruthenium inhibitors of glutathione-S-transferase P1-1 as anticancer drugs

Paul Joseph Dyson, Wee Han Ang

Ruthenium-arene complexes conjugated to ethacrynic acid were prepared as part of a strategy to develop novel glutathione-S-transferase (GST) inhibitors with alternate modes of activity through the organometallic fragment, ultimately to provide targeted rut ...

Wiley-Blackwell2007

Regioselectivity in aqueous palladium catalysed hydroxycarbonylation of styrene: a catalytic and mechanistic study

Gabor Laurenczy, Anisoara Ionescu

Regioselectivity control was studied in palladium catalyzed hydroxycarbonylation of styrene in neat water with water-sol. phosphines, mostly trisulfonated triphenylphosphine, TPPTS, but also N-bis(N',N'-diethyl-2-aminoethyl)-4-aminomethylphenyl-diphenylpho ...

2006

New developments on silyl 2-alkenyl sulfinates and their applications to the asymmetric synthesis of polypropionate fragments

Xiaogen Huang

Sulphur dioxide reacts with 1-oxydienes generating zwitterions which are quenched by enoxysilanes to form substituted silyl alkenylsulfinates. These intermediates are desilylated with Bu4NF and the resulting sulfinates react with MeI giving the correspondi ...

EPFL2004