Publications related to Cochlear implant

Unraveling behavior and cortical signals to guide the development of soft neuroprostheses for auditory restoration and spreading depolarization

Neuroprostheses have been used clinically for decades, to help restore or preserve brain functions, when pharmaceutical treatments are inefficient. Although great progress in the field has been made over the years to interface with the nervous system, surf ...

EPFL2024

Long-Term Hearing Outcome After Radiosurgery for Vestibular Schwannoma: A Systematic Review and Meta-Analysis

Constantin Tuleasca, Adrien Jean Régis Maurice Hilaire

BACKGROUND: Stereotactic radiosurgery (SRS) is one of the main treatment options in the management of small to medium size vestibular schwannomas (VSs), because of high tumor control rate and low cranial nerves morbidity. Series reporting long-term hearing ...

LIPPINCOTT WILLIAMS & WILKINS2023

Conformable neural interfaces : from engineering stretchability at the micro-scale to translational applications

Florent-Valéry Coen

Recently, flexible and soft bioelectronic interfaces have been proposed as a solution to improve existing neural interfaces that currently present mechanical mismatch with the soft tissue. These are devices fabricated with thin polymeric or elastomeric bac ...

EPFL2022

Comparison of Responses to DCN vs. VCN Stimulation in a Mouse Model of the Auditory Brainstem Implant (ABI)

Stéphanie Lacour, Florent-Valéry Coen, Nicolas Vachicouras

The auditory brainstem implant (ABI) is an auditory neuroprosthesis that provides hearing to deaf patients by electrically stimulating the cochlear nucleus (CN) of the brainstem. Whether such stimulation activates one or the other of the CN's two major sub ...

SPRINGER2022

Fabrication and validation of an intraneural interface tailored for optic nerve stimulation

Eleonora Borda

Technological progress in materials science and microengineering along with new discoveries in neuroscience have contributed to restore lost or impaired sensory functions by closely interfacing with the nervous system. Electronic devices have begun to be i ...

EPFL2022

Negative Associations of Stress and Anxiety Levels With Cytotoxic and Regulatory Natural Killer Cell Frequency in Chronic Tinnitus

Patrick Karl Alois Neff

BackgroundDepression and anxiety are known to be associated with stress-induced changes in the immune system. Bothersome tinnitus can be related to stress and often co-occurs with depression and anxiety. This study investigates associations of psychologica ...

Frontiers Media2022

Daily Contributors of Tinnitus Loudness and Distress: An Ecological Momentary Assessment Study

Patrick Karl Alois Neff

BackgroundTinnitus is a heterogeneous condition which may be associated with moderate to severe disability, but the reasons why only a subset of individuals is burdened by the condition are not fully clear. Ecological momentary assessment (EMA) allows a be ...

FRONTIERS MEDIA SA2022

Lower glutamate and GABA levels in auditory cortex of tinnitus patients: a 2D-JPRESS MR spectroscopy study

Thorsten Kleinjung, Patrick Karl Alois Neff

We performed magnetic resonance spectroscopy (MRS) on healthy individuals with tinnitus and no hearing loss (n = 16) vs. a matched control group (n = 17) to further elucidate the role of excitatory and inhibitory neurotransmitters in tinnitus. Two-dimensio ...

Nature Research2022

Human Cochlear Nucleus on 7 Tesla Diffusion Tensor Imaging: Insights Into Micro-anatomy and Function for Auditory Brainstem Implant Surgery

Nicolas Vachicouras

Objective:The cochlear nucleus (CN) is the target of the auditory brainstem implant (ABI). Most ABI candidates have Neurofibromatosis Type 2 (NF2) and distorted brainstem anatomy from bilateral vestibular schwannomas. The CN is difficult to characterize as ...

LIPPINCOTT WILLIAMS & WILKINS2020

Sensitivity to temporal parameters of intraneural tactile sensory feedback

Silvestro Micera, Stanisa Raspopovic, Francesco Maria Petrini, Edoardo D'Anna, Ivo Strauss, Giacomo Valle

Background Recent studies have shown that neural stimulation can be used to provide artificial sensory feedback to amputees eliciting sensations referred on the amputated hand. The temporal properties of the neural stimulation modulate aspects of evoked se ...

BioMed Central2020

A 3D Microscaffold Cochlear Electrode Array for Steroid Elution

Jürgen Brugger, Joo Yeon Kim, Jongmoon Jang

In cochlear implants, the electrode insertion trauma during surgery can cause damage residual hearing. Preserving the residual hearing is an important challenge and the localized administration of drugs, such as steroids, is one of the most promising ways, ...

2019

Auditory Brainstem Implants: Recent Progress and Future Perspectives

Stéphanie Lacour, Nicolas Vachicouras

The auditory brainstem implant (ABI) was first developed nearly 40 years ago and provides auditory rehabilitation to patients who are deaf and ineligible for cochlear implant surgery due to abnormalities of the cochlea and cochlear nerve. The aims of the f ...

2019

Microstructured thin-film electrode technology enables proof of concept of scalable, soft auditory brainstem implants

Stéphanie Lacour, Nicolas Vachicouras, Florian Dylan Fallegger, Christina Myra Tringides, Jennifer Mary Adrienne Alice Macron, Valentina Marie Paggi, Yohann Daniel André Thenaisie

Auditory brainstem implants (ABIs) provide sound awareness to deaf individuals who are not candidates for the cochlear implant. The ABI electrode array rests on the surface of the cochlear nucleus (CN) in the brainstem and delivers multichannel electrical ...

2019

Inner ear cellular imaging through scattering bone

Demetri Psaltis, Marilisa Romito

Inner ear imaging is important for the assessment of hearing disorders. A major cause of hearing loss is the damage to the sensory hair cells, which are located inside the cochlea, a spiral-shaped bone in the inner ear. Imaging of intracochear hair cells i ...

SPIE-INT SOC OPTICAL ENGINEERING2019

Imaging hair cells through laser-ablated cochlear bone

Demetri Psaltis, Ye Pu, Marilisa Romito

We report an innovative technique for the visualization of cells through an overlying scattering medium by combining femtosecond laser bone ablation and two-photon excitation fluorescence (TPEF) microscopy. We demonstrate the technique by imaging hair cell ...

2019

Biomedical optical techniques for intracochlear cellular imaging

Marilisa Romito

Imaging the inner ear microanatomy is of great importance for the assessment of the state of the cells responsible for sound detection. Hearing disorders are mainly due to a malfunction of the cochlea, the bone containing the cells inside the inner ear. Un ...

EPFL2019

Selective femtosecond laser ablation via two-photon fluorescence imaging through a multimode fiber

Demetri Psaltis, Christophe Moser, Damien Claude-Marie Loterie, Eirini Kakkava, Donald Benjaman Conkey, Marilisa Romito

We demonstrate the ability of a multimode fiber probe to provide two-photon fluorescence (TPF) imaging feedback that guides the femtosecond laser ablation (FLA) in biological samples for highly selective modifications. We implement the system through the p ...

OPTICAL SOC AMER2019

Circadian Regulation of Cochlear Sensitivity to Noise by Circulating Glucocorticoids

Frédéric Bruno Martin Gachon, Benjamin Dieter Weger

The cochlea possesses a robust circadian clock machinery that regulates auditory function. How the cochlear clock is influenced by the circadian system remains unknown. Here, we show that cochlear rhythms are system driven and require local Bmal1 as well a ...

2019

Soft microfabricated neural implants: a path towards translational implementation

Nicolas Vachicouras

Neuroprosthetics are a class of medical devices that aim to restore lost or impaired functions of the nervous system by electrical stimulation or recording of neural tissue. State of the art neural implants suffer today from a mechanical mismatch compared ...

EPFL2019

Gamma Knife radiosurgery for intravestibular and intracochlear schwannomas

Constantin Tuleasca

BackgroundSchwannomas of the VIIIth cranial nerve are benign tumours, with vast majority occurring in vestibular division. Rarely, they can also arise from distal branches of cochlear, superior or inferior vestibular. We review our experience with Gamma Kn ...

2019