Publications related to Nerve compression syndrome

Recent Advances in Polymeric Drug Delivery Systems for Peripheral Nerve Regeneration

When a traumatic event causes complete denervation, muscle functional recovery is highly compromised. A possible solution to this issue is the implantation of a biodegradable polymeric tubular scaffold, providing a biomimetic environment to support the ner ...

MDPI2023

Combining biophysical models and machine learning to optimize implant geometry and stimulation protocol for intraneural electrodes

Silvestro Micera, Simone Romeni, Elena Losanno, Luca Pierantoni

Objective. Peripheral nerve interfaces have the potential to restore sensory, motor, and visceral functions. In particular, intraneural interfaces allow targeting deep neural structures with high selectivity, even if their performance strongly depends upon ...

IOP Publishing Ltd2023

Cardiovascular response to closed-loop intraneural stimulation of the right vagus nerve: a proof-of-concept study

Silvestro Micera

Vagus nerve stimulation (VNS) is an FDA-approved technique for the neuromodulation of the autonomic nervous system. There are many therapeutic applications where VNS could be used as a therapy, such as cardiovascular diseases, epilepsy, depression, and inf ...

IEEE2023

Wireless neuromodulation with porous silicon

Silvestro Micera

Wireless optoelectronic devices are fabricated by controlling the porosity of p-type silicon, enabling in vivo efficient, non-genetic optoelectronic modulation of peripheral nerve activity. ...

NATURE PORTFOLIO2022

Does powder averaging remove dispersion bias in diffusion MRI diameter estimates within real 3D axonal architectures?

Marco Pizzolato, Tim Bjørn Dyrby

Noninvasive estimation of axon diameter with diffusion MRI holds the potential to investigate the dynamic properties of the brain network and pathology of neurodegenerative diseases. Recent studies use powder averaging to account for complex white matter a ...

ACADEMIC PRESS INC ELSEVIER SCIENCE2022

MorphoSONIC: A morphologically structured intramembrane cavitation model reveals fiber-specific neuromodulation by ultrasound

Silvestro Micera, Esra Neufeld, Elena Vicari, Théo Lemaire

Low-Intensity Focused Ultrasound Stimulation (LIFUS) holds promise for the remote modulation of neural activity, but an incomplete mechanistic characterization hinders its clinical maturation. Here we developed a computational framework to model intramembr ...

CELL PRESS2021

Modeling spinal locomotor circuits for movements in developing zebrafish

Yann Roussel

Many spinal circuits dedicated to locomotor control have been identified in the developing zebrafish. How these circuits operate together to generate the various swimming movements during development remains to be clarified. In this study, we iteratively b ...

eLIFE SCIENCES PUBL LTD2021

Computational approaches to decode grasping force and velocity level in upper-limb amputee from intraneural peripheral signals

Silvestro Micera, Ivo Strauss, Giacomo Valle

Objective. Recent results have shown the potentials of neural interfaces to provide sensory feedback to subjects with limb amputation increasing prosthesis usability. However, their advantages for decoding motor control signals over current methods based o ...

IOP Publishing Ltd2021

Axon regeneration and circuit reorganization after complete spinal cord injury

Sabry Leonardo Barlatey

First human trials involving neuroprosthetic rehabilitation demonstrated recently that significant functional benefits can be achieved with lumbosacral neuromodulation and reorganized spared projections. However, complete spinal cord injuries (SCI) wholly ...

EPFL2019

Microchannel-based technologies for nerve interfacing

Sandra Gribi

Biomedical technologies in neuroprosthetics are made to restore or replace functions from the nervous system, as well as alleviate pathological conditions. Peripheral nerve interfaces use neuromodulatory techniques to inhibit pain or depression, prevent ep ...

EPFL2019

Intraneural sensory feedback restores grip force control and motor coordination while using a prosthetic hand

Silvestro Micera, Francesco Maria Petrini, Ivo Strauss, Giacomo Valle, Francesco Iberite

Objective. Tactile afferents in the human hand provide fundamental information about hand-environment interactions, which is used by the brain to adapt the motor output to the physical properties of the object being manipulated. A hand amputation disrupts ...

2019

Schwann cells ER-associated degradation contributes to myelin maintenance in adult nerves and limits demyelination in CMT1B mice

Maurizio Molinari, Francesca Bianchi

In the peripheral nervous system (PNS) myelinating Schwann cells synthesize large amounts of myelin protein zero (P0) glycoprotein, an abundant component of peripheral nerve myelin. In humans, mutations in P0 cause the demyelinating Charcot-Marie-Tooth 1B ...

2019

A closed-loop hand prosthesis with simultaneous intraneural tactile and position feedback

Silvestro Micera, Stanisa Raspopovic, Francesco Maria Petrini, Edoardo D'Anna, Ivo Strauss, Giacomo Valle, Francesco Iberite

Current myoelectric prostheses allow transradial amputees to regain voluntary motor control of their artificial limb by exploiting residual muscle function in the forearm. However, the overreliance on visual cues resulting from a lack of sensory feedback i ...

AMER ASSOC ADVANCEMENT SCIENCE2019

Characterization of multi-channel intraneural stimulation in transradial amputees

Silvestro Micera, Stanisa Raspopovic, Fiorenzo Artoni, Francesco Maria Petrini, Edoardo D'Anna, Pablo Garcia del Valle, Ivo Strauss, Giacomo Valle

Although peripheral nerve stimulation using intraneural electrodes has been shown to be an effective and reliable solution to restore sensory feedback after hand loss, there have been no reports on the characterization of multi-channel stimulation. A deepe ...

Springer Nature2019

Comparison of linear frequency and amplitude modulation for intraneural sensory feedback in bidirectional hand prostheses

Silvestro Micera, Stanisa Raspopovic, Francesco Maria Petrini, Edoardo D'Anna, Ivo Strauss, Pablo Garcia del Valle, Giacomo Valle, Francesco Iberite

Recent studies have shown that direct nerve stimulation can be used to provide sensory feedback to hand amputees. The intensity of the elicited sensations can be modulated using the amplitude or frequency of the injected stimuli. However, a comprehensive c ...

Nature Research2018

Biomimetic Intraneural Sensory Feedback Enhances Sensation Naturalness, Tactile Sensitivity, and Manual Dexterity in a Bidirectional Prosthesis

Silvestro Micera, Giulio Rognini, Francesco Maria Petrini, Edoardo D'Anna, Ivo Strauss, Giacomo Valle, Francesco Iberite

Peripheral intraneural stimulation can provide tactile information to amputees. However, efforts are still necessary to identify encoding strategy eliciting percepts that are felt as both natural and effective for prosthesis control. Here we compared the n ...

2018

A microfabricated nerve-on-a-chip platform for rapid assessment of neural conduction in explanted peripheral nerve fibers

Sandra Gribi, Stéphanie Lacour, Diego Ghezzi, Sophie du Bois de Dunilac

Peripheral nerves are anisotropic and heterogeneous neural tissues. Their complex physiology restricts realistic in vitro models, and high resolution and selective probing of axonal activity. Here, we present a nerve-on-a-chip platform that enables rapid e ...

Nature Research2018

Imaging neural activity in the ventral nerve cord of behaving adult Drosophila

Michaël Unser, Pavan P Ramdya, Chin-Lin Chen, Florian Aymanns, Denis Fortun, Laura Joan Hermans

To understand neural circuits that control limbs, one must measure their activity during behavior. Until now this goal has been challenging, because limb premotor and motor circuits have been largely inaccessible for large-scale recordings in intact, movin ...

Nature Research2018

Intra- and extra-axonal axial diffusivities in the white matter: Which one is faster?

Ileana Ozana Jelescu, Nicolas Kunz

A two-compartment model of diffusion in white matter, which accounts for intra- and extra-axonal spaces, is associated with two plausible mathematical scenarios: either the intra-axonal axial diffusivity Da,‖ is higher than the extra-axonal De,‖ (Branch 1) ...

2018

Hybrid peripheral-spinal neuroprosthesis for refined motor execution after paralysis

Sophie Marie Marthe Wurth

Spinal cord injury (SCI) disrupts the communication between the brain and the spinal circuits responsible for movement, thereby causing severe motor deficits. Current strategies to restore function to paralyzed limbs have separately investigated electrical ...

EPFL2018