Publications related to Macula

Neuroprotection in the Retina: From Preventing Inflammatory Cell Death to Promoting Vascular Stability in the Central Nervous System

Glaucoma is one of the leading causes of irreversible blindness worldwide. Glaucoma is defined clinically as the presence of optic nerve head (ONH) degeneration and progressive loss of retinal ganglion cells (RGCs). Intra-ocular pressure (IOP) has been con ...

EPFL2024

Influence of macular pigment on the sensitivity to discomfort glare from daylight

Marilyne Andersen, Jan Wienold, Sneha Jain

Understanding the factors that influence the human perception of glare is necessary to properly address glare risks in buildings and achieve comfortable visual environments, especially in the workplace. Yet large inter-individual variabilities in glare per ...

Nature Research2023

Discomfort glare from daylight: Influence of transmitted color and the eye's macular pigment

Sneha Jain

Designing architectural façades that allow sufficient daylight to create visually comfortable and pleasant environments is a challenging aspect of building design. It requires accounting for visual comfort and discomfort glare risks and understanding the f ...

EPFL2023

Evaluating contrast sensitivity in early and intermediate age-related Macular Degeneration with the Quick Contrast Sensitivity Function

Michael Herzog, Simona Adele Garobbio

Purpose: The purpose of this study was to describe, validate, and compare the contrast sensitivity functions (CSFs) acquired with the novel quick CSF (qCSF) method from patients with early and intermediate age-related macular degeneration (eAMD and iAMD) a ...

2023

In Vivo Retinal Pigment Epithelium Imaging using Transscleral Optical Imaging in Healthy Eyes

Christophe Moser, Timothé Laforest, Laura Emmanuelle Kowalczuk, Mathieu Künzi

Objective: To image healthy retinal pigment epithelial (RPE) cells in vivo using Transscleral OPtical Imaging (TOPI) and to analyze statistics of RPE cell features as a function of age, axial length (AL), and eccentricity. Design: Single-center, explorator ...

ELSEVIER2022

Incomplete Recovery of Zebrafish Retina Following Cryoinjury

Dylan Lawless

Zebrafish show an extraordinary potential for regeneration in several organs from fins to central nervous system. Most impressively, the outcome of an injury results in a near perfect regeneration and a full functional recovery. Indeed, among the various i ...

MDPI2022

On Sensitivity to Glare and Its Relationship with Macular Pigment

Marilyne Andersen, Jan Wienold, Sneha Jain

Current trends in discomfort glare research have suggested the influence of physiological parameters on individual glare perception. To this end, we hypothesize that a specific ocular physiology characteristic, namely the macular pigment (MP) in the retina ...

2021

Optical phase contrast imaging of human retinal cells by changing the tissue refractive index

Christophe Moser, Timothé Laforest, Laura Emmanuelle Kowalczuk, Mathieu Künzi

Purpose : Based on oblique partially coherent illumination of transparent samples, we developed a simple custom Optical Phase Imaging (OPI) microscope providing a label-free, semi-quantitative phase contrast imaging. The aim of this study was to explore th ...

ASSOC RESEARCH VISION OPHTHALMOLOGY INC2020

Long-lasting feature integration

Leila Drissi Daoudi - Kleinbauer

In the classic model of vision, processing is local, feedforward and hierarchical. The first stages of the visual system are retinotopic, i.e., neighboring points in the outside world are mapped onto neighboring photoreceptors of the retina and this is pre ...

EPFL2020

Transscleral optical phase imaging of the human retina

Christophe Moser, Timothé Laforest, Laura Emmanuelle Kowalczuk, Dino Carpentras

In vivo observation of the human retina at the cellular level is crucial to detect the first signs of retinal diseases and properly treat them. Despite the phenomenal advances in adaptive optics systems, clinical imaging of many retinal cells is still elus ...

Nature Publishing Group2020

What is the 'spectral diet' of humans?

Marilyne Andersen, Forrest Simon Webler, Manuel Spitschan

Our visual perception of the world - seeing form and colour or navigating the environment - depends on the interaction of light and matter in the environment. Light also has a more fundamental role in regulating rhythms in physiology and behaviour, as well ...

ELSEVIER2019

Beyond Bouma's window: How to explain global aspects of crowding?

Michael Herzog, Gregory Francis, Adrien Christophe Doerig, Aaron Michael Clarke, Alban Bornet

In crowding, perception of an object deteriorates in the presence of nearby elements. Although crowding is a ubiquitous phenomenon, since elements are rarely seen in isolation, to date there exists no consensus on how to model it. Previous experiments show ...

2019

System, method and apparatus for retinal absorption phase and dark field imaging with oblique illumination

Christophe Moser, Timothé Laforest, Mathieu Künzi, Dino Carpentras

A method for imaging a tissue of an eye, the method including the steps of providing oblique illumination to the eye by a plurality of light emitting areas of a light delivery device, the plurality of light emitting areas being independently controllable a ...

2017

From retinotopic processing to nonretinotopic representation

Marc Michael Lauffs

Encoding of visual information in the brain is retinotopic: Neighboring points in the visual field are mapped onto neighboring photoreceptors in the retina, and these neighborhood relations are maintained in the early stages of cortical processing. However ...

EPFL2017

Mutations in the polyglutamylase geneTTLL5, expressed in photoreceptor cells and spermatozoa, are associated with cone-rod degeneration and reduced male fertility

Hereditary retinal degenerations encompass a group of genetic diseases characterized by extreme clinical variability. Following next-generation sequencing and autozygome-based screening of patients presenting with a peculiar, recessive form of cone-dominat ...

Oxford University Press2016

Release of crowding by pattern completion

Michael Herzog, Gregory Francis, Mauro Manassi

In crowding, target perception deteriorates in the presence of flanking elements. Crowding is classically explained by low-level mechanisms such as pooling or feature substitution. However, we have previously shown that perceptual grouping between the targ ...

Association for Research in Vision and Ophthalmology2015

Derivation of Traceable and Transplantable Photoreceptors from Mouse Embryonic Stem Cells

Freddy Radtke, Ute Koch

Retinal degenerative diseases resulting in the loss of photoreceptors are one of the major causes of blindness. Photoreceptor replacement therapy is a promising treatment because the transplantation of retina-derived photoreceptors can be applied now to di ...

Cell Press2014

A Retina-Inspired Robust On-Focal-Plane Multi-Band Edge-Detection Scheme for CMOS Image Sensors

Alexandre Schmid, Yusuf Leblebici, Nikola Katic

An edge-detection scheme suitable for machine vision and digital motion detection applications is presented. The scheme is inspired by the human visual system (human retina) and modified for a compact and scalable CMOS hardware implementation. In addition, ...

IEEE2014

Retinal pigment epithelium protein of 65 kDA gene-linked retinal degeneration is not modulated by chicken acidic leucine-rich epidermal growth factor-like domain containing brain protein/Neuroglycan C/chondroitin sulfate proteoglycan 5

Pascal Escher

Purpose: To analyze in vivo the function of chicken acidic leucine-rich epidermal growth factor-like domain containing brain protein/Neuroglycan C (gene symbol: Cspg5) during retinal degeneration in the Rpe65(-/-) mouse model of Leber congenital amaurosis. ...

Molecular Vision2013

Grouping, pooling, and when bigger is better in visual crowding

Michael Herzog, Bilge Sayim, Mauro Manassi

In crowding, perception of a target is strongly deteriorated by nearby elements. Crowding is often explained by pooling models predicting that adding flankers increases crowding. In contrast, the centroid hypothesis proposes that adding flankers decreases ...

Association for Research in Vision and Ophthalmology2012