Publications related to Lipid profile

Model-based electron density estimation using multiple diagnostics on TCV

Olivier Sauter, Federico Alberto Alfredo Felici, Cristian Galperti

Estimation of the dynamic evolution of the electron plasma density during a tokamak discharge is crucial since it directly affects the plasma performance, confinement and stability. Therefore it needs to be monitored and controlled. Knowledge of the densit ...

ELSEVIER SCIENCE SA2023

Mitochondrial respiratory chain dysfunction disrupts intracellular cholesterol homeostasis

Christopher Tadhg James Wall

Mitochondrial diseases are rare and severe conditions with debilitating symptoms. Biochemical defects in mitochondria however are common. The difference between these two frequencies is suspected to lie in the capability of the cells to adapt to the homeos ...

EPFL2022

TDCOSMO VII. Boxyness/discyness in lensing galaxies: Detectability and impact on H-0

Aymeric Alexandre Galan, Georgios Vernardos

In the context of gravitational lensing, the density profile of lensing galaxies is often considered to be perfectly elliptical. Potential angular structures are generally ignored, except to explain flux ratios of point-like sources (i.e. flux ratio anomal ...

EDP SCIENCES S A2022

Study of impurity ion transport using charge exchange spectroscopy on TCV

Filippo Bagnato

The study of impurity transport in fusion plasmas has gained interest over the years due to its implication with tokamak performances. In TCV (Tokamak à Configuration Variable), as in many other facilities, impurity ions can be studied through the CXRS (Ch ...

EPFL2022

Cardiotrophin-1 Deficiency Abrogates Atherosclerosis Progression

Nikolaos Stergiopoulos, Rodrigo Araujo Fraga Da Silva

Cardiotrophin-1 (CT-1) is associated with cardiovascular (CV) diseases. We investigated the effect of CT-1 deficiency in the development and progression of atherosclerosis in double knockout Apoe(-/-)ct-1(-/-) mice. Apoe(-/-) C57Bl/6 or Apoe(-/-)ct-1(-/-) ...

Nature Research2020

Long noncoding RNA SNHG12 integrates a DNA-PK-mediated DNA damage response and vascular senescence

Johan Auwerx, Norman Lionel Moullan, Lei Chen

Long noncoding RNAs (lncRNAs) are emerging regulators of biological processes in the vessel wall; however, their role in atherosclerosis remains poorly defined. We used RNA sequencing to profile lncRNAs derived specifically from the aortic intima of Ldlr(- ...

AMER ASSOC ADVANCEMENT SCIENCE2020

Drug-induced increase in lysobisphosphatidic acid reduces the cholesterol overload in Niemann-Pick type C cells and mice

Marc Moniatte, Jonathan Paz Montoya

Most cells acquire cholesterol by endocytosis of circulating low-density lipoproteins (LDLs). After cholesteryl ester de-esterification in endosomes, free cholesterol is redistributed to intracellular membranes via unclear mechanisms. Our previous work sug ...

2019

Hypericin can cross barriers in the chicken's chorioallantoic membrane model when delivered in low-density lipoproteins

Georges Wagnières, Veronika Huntosova

Background: Low-density lipoproteins (LDL) were used as a natural drug delivery system for the transport of hypericin (Hyp) in the bloodstream of the chicken's chorioallantoic membrane model (CAM). Hyp was chosen as a model for hydrophobic drug used in pho ...

ELSEVIER SCIENCE BV2018

Frequent walkers: from healthy individual behaviours to sustainable mobility futures

Derek Pierre Christie

Walking is often taken for granted or considered as an ancillary activity. Little is known about the distribution of walking in contemporary populations, and even less about the few people who walk for an hour or more in public space on most days of the we ...

EPFL2018

Associations between Daily Walking and Subclinical Health Markers in a Swiss City

Vincent Kaufmann, Emmanuel Pierre Jean Ravalet, Derek Pierre Christie, Idris Guessous

Every year, the Health Bus (Bus Santé) enables a representative sample of around 1000 members of the non-institutionalised adult population of Geneva, Switzerland, to undergo a health evaluation including physical measurements, blood tests and questionnair ...

2017

Lipid membrane characterization with second harmonic scattering : surface potentials, ionization, membrane asymmetry and hydration

Cornelis Ulrich Lütgebaucks

Membranes, composed of a variety of lipids and other biomolecules, mediate signaling processes between cells and their aqueous environment. To fulfill this function, membranes can vary their composition leaflet-specific and thus alter their surface propert ...

EPFL2017

An Interferon Regulated MicroRNA Provides Broad Cell-Intrinsic Antiviral Immunity through Multihit Host-Directed Targeting of the Sterol Pathway

Mathieu Blanc

In invertebrates, small interfering RNAs are at the vanguard of cell-autonomous antiviral immunity. In contrast, antiviral mechanisms initiated by interferon (IFN) signaling predominate in mammals. Whilst mammalian IFN-induced miRNA are known to inhibit sp ...

Public Library Science2016

Inflammatory and metabolic responses to high-fat meals with and without dairy products in men

Martinus Gijs, Guy Vergères

Postprandial inflammation is an important factor for human health since chronic low-grade inflammation is associated with chronic diseases. Dairy products have a weak but significant anti-inflammatory effect on postprandial inflammation. The objective of t ...

Cambridge University Press2015

Treatment with KLEPTOSE (R) CRYSMEB reduces mouse atherogenesis by impacting on lipid profile and Th1 lymphocyte response

Anne-Laure Gassner

The ability of pharmacological agents to target both "classical" risk factors and inflammation may be key for successful outcomes in the prevention and treatment of atherogenesis. Among the promising drugs interfering with cholesterol metabolism, we invest ...

Elsevier Science Inc2015

Diminazene Protects Corpus Cavernosum Against Hypercholesterolemia-Induced Injury

Nikolaos Stergiopoulos, Mikaël Nils Sturny, Rafaela Fernandes Da Silva, Fabiana Pereira Da Costa Fraga, Younouss Faye

IntroductionAngiotensin-converting enzyme 2 (ACE2) is a key enzyme of the renin angiotensin system, which breaks down angiotensin II and forms angiotensin-(1-7). In erectile tissues, it has been documented that angiotensin II contributes to the development ...

Wiley-Blackwell2015

Impact of hepatic lipid accumulation and composition on glucose tolerance and insulin sensitivity: a longitudinal study in male and female mice

Rolf Gruetter, Hongxia Lei, Ana Francisca Leal Silva Soares

Background and aims: Metabolic disruptions characterized by high hepatic lipid content (HLC) are associated with impairments in whole body glucose homeostasis. To gain insight on the role of hepatic lipids in the metabolic performance in the absence artifi ...

Springer2014

Lymphatic vasculature mediates macrophage reverse cholesterol transport in mice

Melody Swartz

Reverse cholesterol transport (RCT) refers to the mobilization of cholesterol on HDL particles (HDL-C) from extravascular tissues to plasma, ultimately for fecal excretion. Little is known about how HDL-C leaves peripheral tissues to reach plasma. We first ...

American Society for Clinical Investigation2013

A tissue-engineered model of the intestinal lacteal for evaluating lipid transport by lymphatics

Melody Swartz, Sandeep Raghunathan, James Brandon Dixon

Lacteals are the entry point of all dietary lipids into the circulation, yet little is known about the active regulation of lipid uptake by these lymphatic vessels, and there lacks in vitro models to study the lacteal-enterocyte interface. We describe an i ...

Wiley-Blackwell2009

Mathematical and numerical models for transfer of low-density lipoproteins through the arterial walls: A new methodology for the model set up with applications to the study of disturbed lumenal flow

Alfio Quarteroni, Paolo Zunino

In this work we introduce and discuss several mathematical models, based on partial differential equations, devised to study the coupled transport of macromolecules as low-density lipoproteins in the blood stream and in the arterial walls. These models are ...

2005