Publications related to Peri-implantitis

Overcorrected Implants for Total Shoulder Arthroplasty

Glenohumeral osteoarthritis is a degenerative shoulder joint disease, which causes the breakdown of articular cartilage and bone. People affected by this disease suffer from severe pain and eventually reduced mobility and poor life quality. This disease is ...

EPFL2021

In vitro and in vivo investigation of bisphosphonate-loaded hydroxyapatite particles for peri-implant bone augmentation

Dominique Pioletti, Ulrike Kettenberger

Locally applied bisphosphonates, such as Zoledronate, have been shown in several studies to inhibit peri-implant bone resorption and recently to enhance peri-implant bone formation. Studies have also demonstrated positive effects of hydroxyapatite particle ...

Wiley-Blackwell2017

Effects of Grafting Density and Film Thickness on the Adhesion of Staphylococcus epidermidis to Poly(2-hydroxy ethyl methacrylate) and Poly(poly(ethylene glycol)methacrylate) Brushes

Harm-Anton Klok, Sorin Alexandru Ibanescu

Thin polymer films that prevent the adhesion of bacteria are of interest as coatings for the development of infection-resistant biomaterials. This study investigates the influence of grafting density and film thickness on the adhesion of Staphylococcus epi ...

Wiley-Blackwell2016

Micromotion and fluid flow around cementless femoral components in total hip arthroplasty

Valérie Hélène Emilie Malfroy Camine

Cementless total hip arthroplasty is a highly successful and reliable procedure to restore joint function and reduce pain in patients with severe osteoarthritis. Nevertheless, despite the technical advances over the last decades in the development of cemen ...

EPFL2016

Development of a Bisphosphonate Delivering Hydrogel for the Augmentation of Impaired Peri-Implant Bone

Ulrike Kettenberger

Osteoporosis is a major health problem in our aging society. This metabolic disease, which is characterized by a deterioration of the bone microarchitecture and a significant loss of bone mass, is affecting a rising number of mostly elderly patients. The m ...

EPFL2014

Does locally delivered Zoledronate influence peri-implant bone formation? – Spatio-temporal monitoring of bone remodeling in vivo

Dominique Pioletti, Ulrike Kettenberger, Julien Ston

Bisphosphonates are known for their strong inhibitory effect on bone resorption. Their influence on bone formation however is less clear. In this study we investigated the spatio-temporal effect of locally delivered Zoledronate on peri-implant bone formati ...

Elsevier2014

Influence of gait loads on implant integration in rat tibiae: Experimental and numerical analysis

John Botsis, Joël Cugnoni, Marco Piccinini

Implanted rat bones play a key role in studies involving fracture healing, bone diseases or drugs delivery among other themes. In most of these studies the implants integration also depends on the animal daily activity and musculoskeletal loads, which affe ...

Elsevier2014

Effect of Micromotion on Morphogen Dynamics in Peri-Implant Healing

Miguel Gortchacow

The primary stability of cementless femoral components is crucial for the long-term success of total hip arthroplasty. We know that the healing phase after surgery is a complex biological process, which is affected by the mechanical environment. Implant lo ...

EPFL2011

Cost Aware Design of Translucent WDM Transport Networks

Sébastien Rumley, Christian Gaumier

Fully-transparent DWDM networks working at 10 Gb/s or more have limited reach. At these high rates, only translucent networks able to fully regenerate the signal when needed can be used to implement long haul transport networks. Since signal regeneration a ...

Ieee Service Center, 445 Hoes Lane, Po Box 1331, Piscataway, Nj 08855-1331 Usa2009

Prediction of bone density around orthopedic implants delivering bisphosphonate

Dominique Pioletti, Alexandre Terrier, Vincent Stadelmann

The fixation of an orthopedic implant depends strongly upon its initial stability. Peri-implant bone may resorb shortly after the surgery. This resorbtion is directly followed by new bone formation and implants fixation strengthening, the so-called seconda ...

2009

Osteoclastogenesis can be mechanically-induced in the peri-implant bone

Dominique Pioletti, Alexandre Terrier, Vincent Stadelmann

Total joint replacements are highly successful in relieving pain and restoring movement of damaged joints. However, the lifespan of the implants is limited. The implant’s long-term stability depends largely on the preservation of periprosthetic bone. Debri ...

2009

Microstimulations at the bone implant interface upregulate osteoclast activation pathway

Dominique Pioletti, Alexandre Terrier, Vincent Stadelmann

Peri-implant bone resorption after total joint arthroplasty is a key parameter in aseptic loosening. Implant wear debris and biomechanical aspects have both been demonstrated to be part of the bone resorption process. However, neither of these two paramete ...

2008

Bone reactions to controlled loading of endosseous implants: a pilot study

John Botsis, Joël Cugnoni

Objectives: To validate an experimental setup designed to apply load onto bone tissue using osseointegrated implants in a rabbit model. Specifically, (1) to design an apparatus capable of generating controlled forces, (2) to assess implant placement, maint ...

Wiley-Blackwell2008

Implants delivering bisphosphonate locally increase periprosthetic bone density in an osteoporotic sheep model. A pilot study

Dominique Pioletti, Alexandre Terrier, Vincent Stadelmann

It is a clinical challenge to obtain a sufficient orthopedic implant fixation in weak osteoporotic bone. When the primary implant fixation is poor, micromotions occur at the bone-implant interface, activating osteoclasts, which leads to implant loosening. ...

2008

A composite biofoam, from research to in vivo validation

Dominique Pioletti, Pierre-Etienne Bourban

Bone tissue engineering aims at developing scaffolds, or porous structures, as supports for cell migration, proliferation and differentiation, in order to favor bone healing. L-poly lactic acid (PLA) foams, which were reinforced or not with β-tricalcium ph ...

2007

Bone-cement interface of the glenoid component: stress analysis for varying cement thickness

Alexandre Terrier, Alain Farron, Philippe Büchler

BACKGROUND: Although shoulder arthroplasty is an accepted treatment for osteoarthritis, loosening of the glenoid component, which mainly occurs at the bone-cement interface, remains a major concern. Presently, the mechanical effect of the cement mantel thi ...

2005