Publications related to Saturated fat

Characterization of the gut-bone marrow axis through bile acid signaling

Communication between the intestine and other organs such as the lungs, brain or bones is mediated by several metabolites, like short-chain fatty acids or bile acids, that relay information about nutritional and microbiota status. Bile acids are endogenous ...

EPFL2024

The influence of water-saturation on the strength of volcanic rocks and the stability of lava domes

Marie Estelle Solange Violay, Michael Heap

The rocks forming a volcanic edifice or dome are typically saturated or partially-saturated with water. However, most experiments aimed at better understanding the mechanical behaviour of volcanic rocks have been performed on dry samples, and therefore mos ...

2023

Cognitive Impairment and Metabolite Profile Alterations in the Hippocampus and Cortex of Male and Female Mice Exposed to a Fat and Sugar-Rich Diet are Normalized by Diet Reversal

João Miguel das Neves Duarte, Adélaïde Alice Mohr

Diabetes impacts on brain metabolism, structure, and function. Alterations in brain metabolism have been observed in obesity and diabetes models induced by exposure to diets rich in saturated fat and/or sugar and have been linked to memory impairment. Howe ...

INT SOC AGING & DISEASE2022

Raman microspectroscopy reveals unsaturation heterogeneity at the lipid droplet level and validates an in vitro model of bone marrow adipocyte subtypes

Olaia Maria Naveiras Torres-Quiroga, Charles Christopher Bataclan, Vasco Ledebur de Antas de Campos, Josefine Catharina Pedersen Tratwal, Daniel Naveed Tavakol

Bone marrow adipocytes (BMAds) constitute the most abundant stromal component of adult human bone marrow. Two subtypes of BMAds have been described, the more labile regulated adipocytes (rBMAds) and the more stable constitutive adipocytes (cBMAds), which d ...

FRONTIERS MEDIA SA2022

Life cycle environmental assessment of retaining walls in unsaturated soils

Alessio Ferrari, Gianluca Speranza

Retaining structures above groundwater level support soils that are usually in a state of partial saturation and subject to the actions of atmospheric agents. The current design approach considers the possible extremes of soil conditions - either totally d ...

ELSEVIER2022

Coupled hydro-mechanical analysis of compacted bentonite behaviour during hydration

Lyesse Laloui, Alessio Ferrari, Jose Antonio Bosch Llufriu

This study analyses the response of compacted bentonites upon hydration based on a coupled hydro-mechanical elasto-plastic framework. As an alternative to multi-porosity interpretation, the framework was selected based on the experimental evidence of adsor ...

2021

Nutrients influence seasonal metabolic patterns and total productivity of Arctic streams

Luis Gómez Gener

The seasonality of gross primary production (GPP) in streams is driven by multiple physical and chemical factors, yet incident light is often thought to be most important. In Arctic tundra streams, however, light is available in saturating amounts througho ...

American Society of Limnology and Oceanography2021

Functional kleptoplasts intermediate incorporation of carbon and nitrogen in cells of the Sacoglossa sea slug Elysia viridis

Anders Meibom, Stéphane Laurent Escrig, Charlotte Madeleine Nicole Lekieffre, Michael Kühl

Some sacoglossan sea slugs incorporate intracellular functional algal chloroplasts, a process termed kleptoplasty. "Stolen" chloroplasts (kleptoplasts) can remain photosynthetically active up to several months, contributing to animal nutrition. Whether thi ...

Nature Research2020

Probing the Global Cellular Responses to Lipotoxicity Caused by Saturated Fatty Acids

Manuele Piccolis

Excessive levels of saturated fatty acids are toxic to cells, although the basis for this lipotoxicity remains incompletely understood. Here, we analyzed the transcriptome, lipidome, and genetic interactions of human leukemia cells exposed to palmitate. Pa ...

CELL PRESS2019

The Exchangeable Apolipoprotein Nplp2 Sustains Lipid Flow and Heat Acclimation in Drosophila

Bruno Lemaitre, Jean Philippe Boquete, Samuel Rommelaere, Jérémie Piton

In ectotherms, increased ambient temperature requires the organism to consume substantial amounts of energy to sustain a higher metabolic rate, prevent cellular damage, and respond to heat stress. Here, we identify a heat-inducible apolipoprotein required ...

2019

Neurochemical Modifications in the Hippocampus, Cortex and Hypothalamus of Mice Exposed to Long-Term High-Fat Diet

João Miguel das Neves Duarte, Ana Francisca Leal Silva Soares, Blanca Lizarbe Serra

Metabolic syndrome and diabetes impact brain function and metabolism. While it is well established that rodents exposed to diets rich in saturated fat develop brain dysfunction, contrasting results abound in the literature, likely as result of exposure to ...

2019

An experimental investigation on the water retention behaviour of a silty soil for the computation of the lateral earth thrust on a retaining wall

Lyesse Laloui, Alessio Ferrari, Gianluca Speranza

Retaining structures often interact with soils in unsaturated conditions and their performance is influenced by environmental actions. Currently, geotechnical analysis and design approaches mainly consider the soils either totally dry or totally saturated. ...

E3S Web of Conferences2019

High-fat diet consumption alters energy metabolism in the mouse hypothalamus

Rolf Gruetter, João Miguel das Neves Duarte, Antoine Timothée Cherix, Blanca Lizarbe Serra, Jean-René Cardinaux

BACKGROUND/OBJECTIVES: High-fat diet consumption is known to trigger an inflammatory response in the hypothalamus, which has been characterized by an initial expression of pro-inflammatory genes followed by hypothalamic astrocytosis, microgliosis, and the ...

2019

N-acetylaspartate availability is essential for juvenile survival on fat-free diet and determines metabolic health

Johan Auwerx, Dina Hofer

N-acetylaspartate (NAA) is synthesized by aspartate N-acetyltransferase (gene: Nat8l) from acetyl-coenzyme A and aspartate. In the brain, NAA is considered an important energy metabolite for lipid synthesis. However, the role of NAA in peripheral tissues r ...

2019

Hypericin can cross barriers in the chicken's chorioallantoic membrane model when delivered in low-density lipoproteins

Georges Wagnières, Veronika Huntosova

Background: Low-density lipoproteins (LDL) were used as a natural drug delivery system for the transport of hypericin (Hyp) in the bloodstream of the chicken's chorioallantoic membrane model (CAM). Hyp was chosen as a model for hydrophobic drug used in pho ...

ELSEVIER SCIENCE BV2018

Hydro-mechanical characterization of gas shales and Opalinus Clay shale in partially saturated conditions

Alberto Minardi

An experimental study on the behaviour of shales in partially water saturated conditions is presented in this thesis. The Opalinus Clay shale and gas shales from different unconventional reservoirs have been studied. Opalinus Clay is currently considered a ...

EPFL2018

Synergistic effect of carboxylic and amine ligands on the synthesis of CdSe nanocrystals

Martinus Gijs, Virendra Kumar Parashar

We demonstrate the drastic improvement in absorbance and photoluminescence (UV-PL) of CdSe nanocrystals (NCs) upon adding both a carboxylic acid and an amine ligand to the cadmium acetate green chemistry source. We combined carboxylate complexes of lauric ...

Royal Soc Chemistry2016

Saturated simple and k-simple topological graphs

János Pach, Jan Kyncl

A simple topological graph G is a graph drawn in the plane so that any pair of edges have at most one point in common, which is either an endpoint or a proper crossing. G is called saturated if no further edge can be added without violating this condition. ...

Elsevier Science Bv2015

Hybrid polarizing solids for pure hyperpolarized liquids through dissolution dynamic nuclear polarization

David Lyndon Emsley, Geoffrey Bodenhausen, Aurélien Bornet, Sami Jannin, Jonas Milani, Basile Vuichoud, David Benjamin Roger Antoine Gajan

Hyperpolarization of substrates for magnetic resonance spectroscopy (MRS) and imaging (MRI) by dissolution dynamic nuclear polarization (D-DNP) usually involves saturating the ESR transitions of polarizing agents (PAs; e.g., persistent radicals embedded in ...

National Academy of Sciences2014

From food to physiology characterization and in vitro digestion of milk products and investigation of postprandial metabolism and inflammation after a high-fat meal intake in a human nutrition intervention study

Flurina Schwander

According to the World Health Organization worldwide obesity has more than doubled since 1980. The World health statistics 2012 report shows that one in six adults is obese, one in ten diabetic and one in three has a raised blood pressure. Overweight and o ...

EPFL2013