Concept

BRCA mutation

Related lectures (13)

BRCA2 Mutations: Mechanisms and Implications

Explores BRCA2 mutations, DNA repair mechanisms, and therapeutic implications for BRCA mutant cancers.

Explores p53's pivotal role in cellular stability, DNA repair, and tumor suppression, emphasizing TP53 mutations and DNA double-strand break repair mechanisms.

Retinoblastoma: Tumor Suppressor Genes

Explores tumor suppressor genes in human cancers, focusing on retinoblastoma genetic predisposition and RB gene mutations.

DNA Repair Mechanisms

Explores DNA repair mechanisms, DNA damage response, and synthetic lethality in cancer.

Altered Metabolism in Cancer: Warburg Effect and MYC Regulation

Explores altered cancer metabolism, MYC regulation, Rb and p53 pathways, AKT re-activation, and protein-protein interactions.

DNA Damage Response and Tumor Suppressor Genes

Delves into DNA damage response, tumor suppressor genes, and mutant P53 in cancer.

DNA Replication: Practical Applications and Errors

Explores practical applications of DNA replication, including PCR techniques and forensic analysis.

Small Molecule Drugs: Genetic Diseases

Delves into the molecular basis of genetic diseases, discussing specific examples like Phenylketonuria and Haemophilia A, and the development of small molecule drugs for genetic disorders.

Mutations and Cancer: The Role of P53 and HPV

Covers mutations, the role of P53 in cancer, and HPV's impact on tumorigenesis.

DNA Replication and Cancer

Explores the link between DNA replication, DNA repair mechanisms, and cancer development.

Human Tumor Suppressor Genes

Explores human tumor suppressor genes and genetic predisposition to cancer, using retinoblastoma as a model for tumor formation.

Selective Drug Targeting Mechanisms

Explores selective drug targeting mechanisms, resistance development, tuberculosis incidence, BCR-ABL mutations, tyrosine kinase inhibitors, drug toxicity, interactions, and toxicology studies.

Altered Pathways in Cancer: Signaling Cascades and Mutations

Explores cancer pathways, major signaling cascades, and mutations in RAS and BRAF genes.