Publications related to Ischemic cascade

Evaluating the potential of hyperpolarised [1-13C] L-lactate as a neuroprotectant metabolic biosensor for stroke

Mor-Miri Mishkovsky, Mario Gaetano Lepore, Jean-Noël Hyacinthe, Thanh Phong Kevin Lê, Lara Buscemi Estefanell

Cerebral metabolism, which can be monitored by magnetic resonance spectroscopy (MRS), changes rapidly after brain ischaemic injury. Hyperpolarisation techniques boost (13)C MRS sensitivity by several orders of magnitude, thereby enabling in vivo monitoring ...

Nature Research2020

Stroke and Amyloid-beta Downregulate TREM-2 and Uch-L1 Expression that Synergistically Promote the Inflammatory Response

Ivan Enrico Repetto

Neuroinflammation is involved in the pathogenesis of Alzheimer's disease, and the transcription factor NF-kappa B is a player in this event. We found here that the ischemic damage alone or in association with A beta(1-42) activates the NF-kappa B pathway, ...

2019

Cortico-Muscular Coherence Is Reduced Acutely Post-stroke and Increases Bilaterally During Motor Recovery: A Pilot Study

José del Rocio Millán Ruiz, Serafeim Perdikis, Tiffany Corbet

Motor recovery following stroke is believed to necessitate alteration in functional connectivity between cortex and muscle. Cortico-muscular coherence has been proposed as a potential biomarker for post-stroke motor deficits, enabling a quantification of r ...

2019

Improvement of a Closed Chest Porcine Myocardial Infarction Model by Standardization of Tissue and Blood Sampling Procedures

Jonas Alfred Karl Wilbs

Myocardial ischemia reperfusion (I/R) injury contributes to almost half of the necrotic area after myocardial infarction. To date there is no approved drug to prevent or reduce myocardial I/R injury. The study and understanding of the pathophysiological me ...

JOURNAL OF VISUALIZED EXPERIMENTS2018

Numerical approximation of cardiac electro-fluid-mechanical models : coupling strategies for large-scale simulation

Antonello Gerbi

The mathematical modeling of the heart involves several challenges, which are intrinsically related to the complexity of its function. A satisfactory cardiac model must be able to describe a wide range of different processes, such as the evolution of the t ...

EPFL2018

Neuroplastic Changes Following Brain Ischemia and their Contribution to Stroke Recovery: Novel Approaches in Neurorehabilitation

Silvestro Micera, Stefano Lai

Ischemic damage to the brain triggers substantial reorganization of spared areas and pathways, which is associated with limited, spontaneous restoration of function. A better understanding of this plastic remodeling is crucial to develop more effective str ...

Frontiers Media Sa2017

Treatment with Angiotensin-(1-7) reduces inflammation in carotid atherosclerotic plaques

Nikolaos Stergiopoulos, Katia Galan, Rafaela Fernandes Da Silva, Fabiana Pereira Da Costa Fraga, Luciano Dos Santos Aggum Capettini

Angiotensin (Ang)-(1-7), acting through the receptor Mas, has athero-protective effects; however, its role on plaque vulnerability has been poorly studied. Here, we investigated the expression of the renin-angiotensin system (RAS) components in stable and ...

Schattauer2014

Long-lasting fibrin matrices ensure stable and functional angiogenesis by highly tunable, sustained delivery of recombinant VEGF(164)

Jeffrey Alan Hubbell, Veronica Sacchi, Mikaël Martino, Kristen Lorentz, Martin Ehrbar, Elena Groppa

Clinical trials of therapeutic angiogenesis by vascular endothelial growth factor (VEGF) gene delivery failed to show efficacy. Major challenges include the need to precisely control in vivo distribution of growth factor dose and duration of expression. Re ...

National Academy of Sciences2014

PHD2 regulates arteriogenic macrophages through TIE2 signalling

Michele De Palma, Mario Leonardo Squadrito, Ferdinando Pucci

Occlusion of the main arterial route redirects blood flow to the collateral circulation. We previously reported that macrophages genetically modified to express low levels of prolyl hydroxylase domain protein 2 (PHD2) display an arteriogenic phenotype, whi ...

Wiley-Blackwell2013

New Evidence of Neuroprotection by Lactate after Transient Focal Cerebral Ischaemia: Extended Benefit after Intracerebroventricular Injection and Efficacy of Intravenous Administration

Pierre Magistretti, Ximena Castillo

Background: Lactate protects mice against the ischaemic damage resulting from transient middle cerebral artery occlusion (MCAO) when administered intracerebroventricularly at reperfusion, yielding smaller lesion sizes and a better neurological outcome 48 h ...

Karger2012

High-resolution spatial mapping of changes in the neurochemical profile after focal ischemia in mice

Rolf Gruetter, Hongxia Lei, Malte Alf

After ischemic stroke, the ischemic damage to brain tissue evolves over time and with an uneven spatial distribution. Early irreversible changes occur in the ischemic core, whereas, in the penumbra, which receives more collateral blood flow, the damage is ...

Wiley-Blackwell2012

The Angiotensin-Converting Enzyme 2/Angiotensin-(1-7)/Mas receptor axis: A potential target for treating thrombotic diseases

Nikolaos Stergiopoulos, Danielle Gomes Passos Silva

Despite many therapeutic advances leading to increasingly effective drug treatments, thrombotic events (such as ischaemic stroke, pulmonary embolism, deep venous thrombosis and acute myocardial infarction) still represent a major worldwide cause of morbidi ...

Schattauer Gmbh-Verlag Medizin Naturwissenschaften2012

Increase of arginase activity in old apolipoprotein-E deficient mice under Western diet associated with changes in neurovascular unit

Rafaela Fernandes Da Silva, Jean-Christophe Copin

Aging and atherosclerosis are well-recognized risk factors for cardiac and neurovascular diseases. The Apolipoprotein E deficient (ApoE-/-) mouse on a high-fat diet is a classical model of atherosclerosis, characterized by the presence of atherosclerotic p ...

Biomed Central Ltd2012

Comparative analyses of Purkinje cell gene expression profiles reveal shared molecular abnormalities in models of different polyglutamine diseases

Polyglutamine (PolyQ) diseases have common features that include progressive selective neurodegeneration and the formation of protein aggregates. There is growing evidence to suggest that critical nuclear events lead to transcriptional alterations in PolyQ ...

Elsevier Science Bv2012

Early Predictive Biomarkers for Lesion After Transient Cerebral Ischemia

Rolf Gruetter, Hongxia Lei

Background and Purpose—Despite the improving imaging techniques, it remains challenging to predict the outcome early after transient cerebral ischemia. The aim of this study was thus to identify early metabolic biomarkers for outcome prediction. Methods—We ...

2011

Cell-responsive hydrogel for encapsulation of vascular cells

Jeffrey Alan Hubbell

The in vitro potential of a synthetic matrix metalloproteinase (MMP)-responsive poly(ethylene glycol) (PEG)-based hydrogel as a bioactive co-encapsulation system for vascular cells and a small bioactive peptide, thymosin beta 4 (T beta 4), was examined. We ...

2009

Stem cell-based cardiovascular tissue engineering

Thomas Krähenbühl

Cardiovascular diseases, including myocardial infarction, are the leading cause of death worldwide for both men and women. Current therapies are limited by the restricted intrinsic regeneration capacity of the heart and by the lack of organs for transplant ...

EPFL2009