Publications related to Childhood schizophrenia

The shine-through paradigm and the schizophrenia spectrum: a summary

Michael Herzog, Simona Adele Garobbio, Maya Roinishvili, Ophélie Gladys Favrod, Janir Nuno Ramos Antunes Da Cruz

In the past 10 years, our laboratory has proved the shine-through paradigm to be a very sensitive endophenotype for schizophrenia. The shine-through paradigm is a visual backward masking task, where the target is a vertical vernier followed by a 25-element ...

2021

Electrophysiological correlates of visual backward masking in patients with bipolar disorder

Michael Herzog, Simona Adele Garobbio, Maya Roinishvili, Ophélie Gladys Favrod, Janir Nuno Ramos Antunes Da Cruz

In visual backward masking (VBM), a target is followed by a mask that decreases target discriminability. Schizophrenia patients (SZ) show strong and reproducible masking impairments, which are associated with reduced EEG amplitudes. Patients with bipolar d ...

2021

Electrophysiological correlates of visual backward masking in the schizophrenia continuum

Ophélie Gladys Favrod

In visual backward masking (VBM), a target is followed by a mask. Over the past decade, a VBM task, called the Shine-Through paradigm (ST), has been shown to be a very sensitive endophenotype of schizophrenia. In the present thesis, the electrophysiologica ...

EPFL2019

Electrophysiological correlates of visual backward masking in patients with major depressive disorder

Michael Herzog, Maya Roinishvili, Ophélie Gladys Favrod, Patricia Figueiredo, Janir Nuno Ramos Antunes Da Cruz

Depression and schizophrenia are two psychiatric diseases with high co-morbidity. For this reason, it is important to find sensitive endophenotypes, which may disentangle the two disorders. The Shine-Through paradigm, a visual backward masking task, is a p ...

2019

Visual masking deficits in schizophrenia: A view into the genetics of the disease through an endophenotype

Michael Herzog, Jacques Fellay, Maya Roinishvili, Flavia Aurelia Shoko Hodel

Schizophrenia is a chronic disorder determined by a complex mix of genetic and environmental factors. To better understand the contributions of human genetic variation to schizophrenia, we performed a genome-wide association study of a validated endophenot ...

2018

Diffusion-weighted imaging evidence of altered white matter development from late childhood to early adulthood in Autism Spectrum Disorder

Djalel Eddine Meskaldji, Fikret Isik Karahanoglu

Autism Spectrum Disorder (ASD) is thought to reflect disrupted development of brain connectivity characterized by white matter abnormalities and dyscoordination of activity across brain regions that give rise to core features. But there is little consensus ...

2018

Does chronic nicotine consumption influence visual backward masking in schizophrenia and schizotypy?

Michael Herzog, Christine Mohr, Albulena Jashari-Shaqiri, Maya Roinishvili, Guillaume Sierro

Nicotine consumption is higher for people within the schizophrenia spectrum compared to controls. This observation supports the self-medication hypothesis, that nicotine relives symptoms in, for example, schizophrenia patients. We tested whether performanc ...

2015

Patients with functional psychoses show similar visual backward masking deficits

Michael Herzog, Maya Roinishvili

Recent genetic, behavioral, and clinical studies suggest that functional psychoses (schizophrenia, bipolar disorder, schizoaffective disorder), previously thought to be distinct from each other, may belong to one continuum. The shine-through masking paradi ...

Elsevier2012

Backward masking reveals different visual processing of schizophrenic and depressive patients

Michael Herzog, Maya Roinishvili

Visual backward masking is a very sensitive tool for studying early visual processing deficits and a reliable endophenotype of schizophrenia. Mental diseases strongly overlap in many aspects, for example, in psychopathology, cognition, and genetics. Here, ...

Pion Ltd.2012

Deteriorated visual backward masking in the shine-through effect in adolescents with psychosis

Michael Herzog

Visual backward masking is a reliable and widely used tool in schizophrenia research. Whereas many studies have shown masking deficits in adult patients, there are only very few studies with adolescents with psychosis-and with controversial results. Maskin ...

Taylor & Francis2009

fMRI activation during a language task in adolescents with ASD

Nouchine Hadjikhani

Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by language and communication impairments, social impairments, and repetitive behaviors or restricted interests. Previous Studies of semantic functions have found differences in ...

Cambridge University Press2008

Altered neocortical microcircuitry in the valproic acid rat model of autism

Tania Rinaldi

Autism is a wide-spectrum disorder with early childhood onset, affecting general cognitive capabilities and, in particular, complex information processing. Although interesting directions of research start to appear, the precise causes of the disorder and ...

EPFL2006