Publications related to Transcranial Doppler

Hypertonic Lactate to Improve Cerebral Perfusion and Glucose Availability After Acute Brain Injury

Objectives: Lactate promotes cerebral blood flow and is an efficient substrate for the brain, particularly at times of glucose shortage. Hypertonic lactate is neuroprotective after experimental brain injury; however, human data are limited. ...

LIPPINCOTT WILLIAMS & WILKINS2018

Pitfalls Of Doppler Measurements For Arterial Blood Flow Quantification In Small Animal Research: A Study Based On Virtual Ultrasound Imaging

Bram Trachet, Patrick Segers

High-resolution Doppler is a popular tool for evaluating cardiovascular physiology in mutant mice, though its 1-D nature and spectral broadening processes complicate interpretation of the measurement. Hence, it is crucial for pre-clinical researchers to kn ...

Elsevier2016

Assessment of shear stress related parameters in the carotid bifurcation using mouse-specific FSI simulations

Bram Trachet, Patrick Segers

The ApoE(-/-) mouse is a common small animal model to study atherosclerosis, an inflammatory disease of the large and medium sized arteries such as the carotid artery. It is generally accepted that the wall shear stress, induced by the blood flow, plays a ...

Elsevier Sci Ltd2016

The effect of continuous positive airway pressure on total cerebral blood flow in healthy awake volunteers

Nikolaos Stergiopoulos, Bryn Andrew Martin

Continuous positive airway pressure (CPAP) is the gold standard treatment for obstructive sleep apnea. However, the physiologic impact of CPAP on cerebral blood flow (CBF) is not well established. Ultrasound can be used to estimate CBF, but there is no wid ...

Springer-Verlag2013

Validation of a patient-specific one-dimensional model of the systemic arterial tree

Nikolaos Stergiopoulos, Philippe Reymond, Yvette Bohraus, François Lazeyras

Reymond P, Bohraus Y, Perren F, Lazeyras F, Stergiopulos N. Validation of a patient-specific one-dimensional model of the systemic arterial tree. Am J Physiol Heart Circ Physiol 301: H1173-H1182, 2011. First published May 27, 2011; doi:10.1152/ajpheart.008 ...

2011

Fractal Modelling And Analysis Of Flow-Field Images

Michaël Unser, Ricard Delgado Gonzalo, Pouya Dehghani Tafti

We introduce stochastic models for flow fields with parameters that dictate the scale-dependent (self-similar) character of the field and control the balance between its rotational vs compressive behaviour. The development of our models is motivated by the ...

Ieee Service Center, 445 Hoes Lane, Po Box 1331, Piscataway, Nj 08855-1331 Usa2010

Validation of a one-dimensional model of the systemic arterial tree

Nikolaos Stergiopoulos, Fabrice Merenda, Philippe Reymond

A distributed model of the human arterial tree including all main systemic arteries coupled to a heart model is developed. The one-dimensional (1-D) form of the momentum and continuity equations is solved numerically to obtain pressures and flows throughou ...

2009

Differential effects of reduced cyclic stretch and perturbed shear stress within the arterial wall

Tyler Nerton Thacher

Due to the pulsatile nature of blood flow, arteries are constantly exposed to dynamic mechanical forces; the pulsatility continuously stretches the vessel wall and the flow creates a frictional force on the interior surface. These stresses, referred to as ...

EPFL2009

Role of arginase pathway in response to shear stress: new potential therapeutic targets for atherosclerosis?

Nikolaos Stergiopoulos, Rafaela Fernandes Da Silva, Veronica Gambillara

Introduction: Alterations of wall shear stress can predispose the endothelium to the development of atherosclerotic plaques. Ample evidence indicates that arginase expression and/or activity correlates with several risk factors for cardiovascular disease i ...

2007

Full Flow/Motion-Field Recovery from Pulsed-Wave Ultrasound Doppler Data

Michaël Unser, Michael Sühling, Muthuvel Arigovindan

We present a new computational method for reconstructing a vector field from scattered, pulsed-wave ultrasound Doppler data. The main difficulty is that the Doppler measurements are incomplete, for they do only capture the velocity component along the beam ...

IEEE2006

Effect of intimal shear and cyclic strech on arterial segments perfused in vitro

Veronica Gambillara

Hemodynamics have crucial role in the control of vascular tone, in the regulation of arterial remodeling, and in the production of mediators that maintain arterial function. Changes in hemodynamics forces induce profound alterations in vascular cell metabo ...

EPFL2005