Publications related to Alcohol and health

Artificial intelligence of things for smart cities: advanced solutions for enhancing transportation safety

In the context of smart cities, ensuring road safety is crucial due to increasing urbanization and the interconnected nature of contemporary urban environments. Leveraging innovative technologies is essential to mitigate risks and create safer communities. ...

Springernature2024

Anti-miR-873-5p improves alcohol-related liver disease by enhancing hepatic deacetylation via SIRT1

Kristina Schoonjans, Petar Petrov

Background & Aims: Current therapies for the treatment of alcohol-related liver disease (ALD) have proven largely ineffective. Patients relapse and the disease progresses even after liver transplantation. Altered epigenetic mechanisms are characteristic of ...

Elsevier2024

Associations between urinary biomarkers of oxidative stress and biomarkers of tobacco smoke exposure in smokers

Florian Frédéric Vincent Breider, Dominique Grandjean, Nicolas Sambiagio

Oxidative stress can contribute to the development of diseases, and may originate from exposures to toxicants commonly found in air pollution and cigarette smoke such as polycyclic aromatic hydrocarbons (PAHs) and volatile organic compounds (VOCs). Yet, as ...

Elsevier2022

Impaired cognitive flexibility and heightened urgency are associated with increased alcohol consumption in rodent models of excessive drinking

Emanuela De Falco

Alcohol use disorder (AUD) is characterized by impairments in decision-making that can exist as stable traits or transient states. Cognitive inflexibility reflects an inability to update information that guides decision-making and is thought to contribute ...

WILEY2021

Learning Urban Nightlife Routines from Mobile Data

Daniel Gatica-Perez, Thanh Trung Phan

The use of smartphone sensing for public health studies is appealing to understand routines. We present an approach to learn nightlife routines in a smartphone sensing dataset volunteered by 184 young people (1586 weekend nights with location data captured ...

ACM2020

Understanding Eating And Drinking In Context From Crowdsourced Data

Thanh Trung Phan

With the increasing rate of urbanization, understanding food and beverage consumption, including alcohol drinking behaviour with its consequences, is relevant in such a megacity in the future. Especially, investigation of alcohol drinking is necessary for ...

EPFL2020

Youth nightlife at home: towards a feminist conceptualisation of home

Daniel Gatica-Perez, Darshan Santani

This paper explores home as a space of youth nightlife and drinking through a feminist lens. It draws on feminist geographical scholarship on home and 40 semi-structured interviews with young people aged 16–25 in Switzerland in the context of a larger inte ...

2021

Understanding Heavy Drinking at Night through Smartphone Sensing and Active Human Engagement

Daniel Gatica-Perez, Skanda Muralidhar, Thanh Trung Phan

Heavy alcohol consumption can lead to many severe consequences. In this paper, we study the phenomenon of heavy drinking at night (4+ drinks for women or 5+ for men on a single evening), using a smartphone sensing dataset depicting about nightlife and drin ...

ACM2020

Nicotinamide riboside supplementation alters body composition and skeletal muscle acetylcarnitine concentrations in healthy obese humans

Johan Auwerx, Richardus Houtkooper

Background: Nicotinamide riboside (NR) is an NAD(+) precursor that boosts cellular NAD(+) concentrations. Preclinical studies have shown profound metabolic health effects after NR supplementation. ...

OXFORD UNIV PRESS2020

Lifetime investment and consumption with recursive preferences and small transaction costs

Yaroslav Melnyk, Johannes Muhle-Karbe

We investigate the effects of small proportional transaction costs on lifetime consumption and portfolio choice. The extant literature has focused on agents with additive utilities. Here, we extend this analysis to the archetype of nonadditive preferences: ...

WILEY2020

Towards Win-Win Policies for Healthy and Sustainable Diets in Switzerland

Arnaud Dauriat, Suren Erkman

The first Swiss national dietary survey (MenuCH) was used to screen disease burdens and greenhouse gas emissions (GHG) of Swiss diets (vegan, vegetarian, gluten-free, slimming), with a focus on gender and education level. The Health Nutritional Index (HENI ...

MDPI2020

The contexts of heavy drinking: A systematic review of the combinations of context-related factors associated with heavy drinking occasions

Background The amount of alcohol consumed during an occasion can be influenced by physical and social attributes of the setting, characteristics and state of individuals, and the interactions of these components. This systematic review identifies and descr ...

2019

DrinkSense: Characterizing Youth Drinking Behavior using Smartphones

Daniel Gatica-Perez, Darshan Santani

Alcohol consumption is the number one risk factor for morbidity and mortality among young people. In late adolescence and early adulthood, excessive drinking and intoxication are more common than in any other life period, increasing the risk of adverse phy ...

2018

What Reminds Young People That They Drank More Than Intended on Weekend Nights: An Event-Level Study

Objective: Young people often drink more alcohol than intended over the course of a night. This study investigates individual and night-specific factors predicting young people’s acknowledgment of having drunk more than intended. Method: Using the Youth@Ni ...

2018

After how many drinks does someone experience acute consequences-determining thresholds for binge drinking based on two event-level studies: Optimal thresholds for binge drinking

Background and Aims: The threshold of 4+/5+ drinks per occasion has been used for decades in alcohol research to distinguish between non risky versus risky episodic drinking. However, no study has assessed the validity of this threshold using event level d ...

2018

A preclinical model for identifying rats at risk of alcohol use disorder

Pierre Magistretti, Benjamin Boutrel

Alcohol use is one of the world's leading causes of death and disease, although only a small proportion of individuals develop persistent alcohol use disorder (AUD). The identification of vulnerable individuals prior to their chronic intoxication remains o ...

Springer Nature2017

PARP inhibition protects against alcoholic and non-alcoholic steatohepatitis

Johan Auwerx, Dongryeol Ryu, Wei Wang, Karim Laurent Gariani, Zhou Zhou

Background & Aims: Mitochondria) dysfunction, oxidative stress, inflammation, and metabolic reprograming are crucial contributors to hepatic injury and subsequent liver fibrosis. Poly(ADP-ribose) polymerases (PARP) and their interactions with sirtuins play ...

Elsevier Science Bv2017

The effects of stress during early postnatal periods on behavior and hippocampal neuroplasticity markers in adult male mice

Maria del Carmen Sandi Perez, Jocelin Grosse, Olivia Zanoletti, Michael van der Kooij

Infancy is a critical period for brain development. Emerging evidence indicates that stress experienced during that period can have long-term programming effects on the brain and behavior. However, whether different time periods represent different vulnera ...

2015

A neuropsychological instrument measuring age-related cerebral decline in older drivers: development reliability, and validity of MedDrive

Michael Herzog, Daniela Herzig, Isabel Cardoso, Paul Vaucher

When facing age-related cerebral decline, older adults are unequally affected by cognitive impairment without us knowing why. To explore underlying mechanisms and find possible solutions to maintain life-space mobility, there is a need for a standardized b ...

Frontiers Research Foundation2014

Long-term behavioral programming induced by peripuberty stress in rats is accompanied by GABAergic-related alterations in the amygdala

Maria del Carmen Sandi Perez, Stamatina Tzanoulinou, Vandana Veenit

Stress during childhood and adolescence is a risk factor for psychopathology. Alterations in γ-aminobutyric acid (GABA), the main inhibitory neurotransmitter in the brain, have been found following stress exposure and fear experiences and are often implica ...

Public Library of Science2014