Publications related to Psychoactive drug

Shared functional connectome fingerprints following ritualistic ayahuasca intake

Enrico Amico, Hanna Tolle, Pablo Mallaroni

The knowledge that brain functional connectomes are unique and reliable has enabled behaviourally relevant inferences at a subject level. However, whether such "fingerprints" persist under altered states of consciousness is unknown. Ayahuasca is a potent s ...

Academic Press Inc Elsevier Science2023

The predictive capacity of in vitro preclinical models to evaluate drugs for the treatment of retinoblastoma

Paul Joseph Dyson, Irina Sinenko, Roland Christopher Turnell-Ritson

Retinoblastoma is a rare childhood cancer of the eye. Of the small number of drugs are used to treat retinoblastoma, all have been repurposed from drugs developed for other conditions. In order to find drugs or drug combinations better suited to the improv ...

ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD2023

Repurposed drug combination via high-throughput screening and dual drug delivery system development for the treatment of retinoblastoma

Po-Jen Tseng

The goal of retinoblastoma (RB) treatment is to save the child's life, eyes and functional vision, with that order of priority. The management of RB is complex and involves strategically chosen methods of surgical enucleation, external beam radiotherapy, i ...

EPFL2022

Laser-induced liquid micro-jets for drug delivery

Jan Krizek

Jet injection devices have been studied and developed for transdermal drug delivery to avoid the use of needles. Such contact-less devices provide several advantages such as better dose control, lateral and depth localisation, lower collateral damage than ...

EPFL2021

Receptor-induced transient responses in cells with oscillatory actin dynamics

Jose Negrete Jr

Living cells adjust their sensing and migratory machinery in response to changes in their environment. In this work, we show that cells of the social amoeba Dictyostelium discoideum modulate the dynamical state of their actin cytoskeleton in response to an ...

AMER PHYSICAL SOC2020

Renormalizing individual performance metrics for cultural heritage management of sports records

Orion B Penner

Individual performance metrics are commonly used to compare players from different eras. However, such cross-era comparison is often biased due to significant changes in success factors underlying player achievement rates (e.g. performance enhancing drugs ...

PERGAMON-ELSEVIER SCIENCE LTD2020

Direct and catalyst-free growth of vertically-stacked graphene-based structures for enhanced drug sensing

Giovanni De Micheli, Sandro Carrara, Nima Aliakbarinodehi

In this work, a complete study is carried out for the optimised, direct and catalyst-free growth of vertically-stacked graphene-based structures targeting at improved performance drug monitoring. The nanostructures, ultimately forming a honeycomb network o ...

IEEE2019

Psychotropic drug-induced genetic-epigenetic modulation of CRTC1 gene is associated with early weight gain in a prospective study of psychiatric patients

Johannes Gräff, Jose Vicente Sanchez Mut, Aurélie Delacrétaz, Céline Dubath

Background: Metabolic side effects induced by psychotropic drugs represent a major health issue in psychiatry. CREB-regulated transcription coactivator 1 (CRTC1) gene plays a major role in the regulation of energy homeostasis and epigenetic mechanisms may ...

2019

Impact of Caffeine Consumption on Type 2 Diabetes-Induced Spatial Memory Impairment and Neurochemical Alterations in the Hippocampus

Rolf Gruetter, João Miguel das Neves Duarte

Diabetes affects the morphology and plasticity of the hippocampus, and leads to learning and memory deficits. Caffeine has been proposed to prevent memory impairment upon multiple chronic disorders with neurological involvement. We tested whether long-term ...

2019

Performance of Carbon Nano-Scale Allotropes in Detecting Midazolam and Paracetamol in Undiluted Human Serum

Giovanni De Micheli, Nima Aliakbarinodehi, Sandro Carrara, Francesca Stradolini, Irene Taurino, Ioulia Tzouvadaki, Sattar Akbari Nakhjavani

Nano-materials are highly exploited to enhance sensing performance of electrochemical electrodes by increasing the Electro-Active Surface Area (EASA). In this work, an analytical calculation of the deposited EASA is presented and experimentally validated b ...

2018

Allosteric cross-talk in chromatin can mediate drug-drug synergy

Paul Joseph Dyson, Ursula Röthlisberger, Tina Riedel, Giulia Palermo

Exploitation of drug-drug synergism and allostery could yield superior therapies by capitalizing on the immensely diverse, but highly specific, potential associated with the biological macromolecular landscape. Here we describe a drug-drug synergy mediated ...

Nature Research2017

Cyber-Medical Systems: Requirements, Components and Design Examples

Giovanni De Micheli

Cyber-medical systems will produce a major revolution in health care, by both raising the quality of care and reducing its cost, thus reaching an important social and economic goal. The evolution of electronic devices and systems has already enabled societ ...

2017

Lactate release from astrocytes to neurons contributes to cocaine memory formation

Pierre Magistretti, Benjamin Boutrel, Benjamin Boury-Jamot

The identification of neural substrates underlying the long lasting debilitating impact of drug cues is critical for developing novel therapeutic tools. Metabolic coupling has long been considered a key mechanism through which astrocytes and neurons active ...

Wiley-Blackwell2016

Antitubercular drugs for an old target: GSK693 as a promising InhA direct inhibitor

John McKinney, Neeraj Dhar, François Signorino-Gelo

Despite being one of the first antitubercular agents identified, isoniazid (INH) is still the most prescribed drug for prophylaxis and tuberculosis (TB) treatment and, together with rifampicin, the pillars of current chemotherapy. A high percentage of ison ...

Elsevier Science Bv2016

A Balance between Inhibitor Binding and Substrate Processing Confers Influenza Drug Resistance

Jeffrey David Jensen, Claudia Bank, Li Jiang

The therapeutic benefits of the neuraminidase (NA) inhibitor oseltamivir are dampened by the emergence of drug resistance mutations in influenza A virus (IAV). To investigate the mechanistic features that underlie resistance, we developed an approach to qu ...

Academic Press Ltd- Elsevier Science Ltd2016

Association of PCK1 with Body Mass Index and Other Metabolic Features in Patients With Psychotropic Treatments

Pierre Magistretti, Aurélie Delacrétaz

Weight gain is a major health problem among psychiatric populations. It implicates several receptors and hormones involved in energy balance and metabolism. Phosphoenolpyruvate carboxykinase 1 is a rate-controlling enzyme involved in gluconeogenesis, glyce ...

Lippincott, Williams & Wilkins2015

Structure-activity relationships of synthetic cannabinoid designer drug RCS-4 and its regioisomers and C4 homologues

Trent Michael Conroy

RCS-4 [(4-methoxyphenyl)-1-yl-(1-pentyl-1H-indol-3-yl)methanone] represents the first of several N-alkyl-3-(methoxybenzoyl)indoles identified by forensic scientists as synthetic cannabinoid (SC) designer drugs. Despite the detection of RCS-4 and several an ...

Springer2015

Next-generation antimicrobials: from chemical biology to first-in-class drugs

Paul Murima

The global emergence of multi-drug resistant bacteria invokes an urgent and imperative necessity for the identification of novel antimicrobials. The general lack of success in progressing novel chemical entities from target-based drug screens have prompted ...

Pharmaceutical Soc Korea2015

A New Outlook on Mental Illnesses: Glial Involvement Beyond the Glue

Pierre Magistretti, Maha Elsayed

Mental illnesses have long been perceived as the exclusive consequence of abnormalities in neuronal functioning. Until recently, the role of glial cells in the pathophysiology of mental diseases has largely been overlooked. However recently, multiple lines ...

Frontiers Media Sa2015

Dual orexin receptor antagonists - promising agents in the treatment of sleep disorders

Damien Lapray

Insomnia is a serious medical and social problem, its prevalence in the general population ranges from 9 to 35% depending on the country and assessment method. Often, patients are subject to inappropriate and therefore dangerous pharmacotherapies that incl ...

Cambridge Univ Press2014