Focuses on large-scale inference for detecting QTL hotspots in sparse regression models, emphasizing the need to use genomics to understand variation in phenotypes and disease susceptibility.
Explores the genetic basis of Prader-Villy syndrome and its comparison with Angelman syndrome, emphasizing DNA methylation patterns and chromosomal abnormalities.
Explores Parkinson's disease, covering its history, challenges in diagnosis, available treatments, neuropathological changes, and impact on motor control.
Covers enzyme inhibition mechanisms, drug modes of action, targeted protein degradation using PROTACs, and the bump-hole method for protein-ligand engineering.
Explores liquid-liquid phase separation in computational cell biology, emphasizing the role of biomolecular condensates and the central dogma of molecular biology.
