Publications related to An Essay on the Principle of Population

Impact of population size on early adaptation in rugged fitness landscapes

Anne-Florence Raphaëlle Bitbol, Richard Marie Servajean

Owing to stochastic fluctuations arising from finite population size, known as genetic drift, the ability of a population to explore a rugged fitness landscape depends on its size. In the weak mutation regime, while the mean steady-state fitness increases ...

ROYAL SOC2023

Hydrodynamic flow and concentration gradients in the gut enhance neutral bacterial diversity

Anne-Florence Raphaëlle Bitbol

The gut microbiota features important genetic diversity, and the specific spatial features of the gut may shape evolution within this environment. We investigate the fixation probability of neutral bacterial mutants within a minimal model of the gut that i ...

National Academy of Sciences2022

The association of basic and challenging motor capacity with mobility performance and falls in young seniors

Kamiar Aminian, Anisoara Ionescu

Background: Understanding the association between motor capacity (MC) (what people can do in a standardized environment), mobility performance (MP) (what people actually do in real-life) and falls is important for early detection of and counteracting on fu ...

ELSEVIER IRELAND LTD2020

Adapt or Perish: Evolutionary Rescue in a Gradually Deteriorating Environment

Anne-Florence Raphaëlle Bitbol, Loïc Marrec

We investigate the evolutionary rescue of a microbial population in a gradually deteriorating environment, through a combination of analytical calculations and stochastic simulations. We consider a population destined for extinction in the absence of mutan ...

2020

Limits on amplifiers of natural selection under death-Birth updating

Andreas Pavlogiannis

The fixation probability of a single mutant invading a population of residents is among the most widely-studied quantities in evolutionary dynamics. Amplifiers of natural selection are population structures that increase the fixation probability of advanta ...

2020

Population structure determines the tradeoff between fixation probability and fixation time

Andreas Pavlogiannis

The rate of biological evolution depends on the fixation probability and on the fixation time of new mutants. Intensive research has focused on identifying population structures that augment the fixation probability of advantageous mutants. But these ampli ...

Springer2019

Fréchet means and Procrustes analysis in Wasserstein space

Victor Panaretos, Yoav Zemel

We consider two statistical problems at the intersection of functional and non-Euclidean data analysis: the determination of a Fréchet mean in the Wasserstein space of multivariate distributions; and the optimal registration of deformed random measures and ...

2019

Computational and Statistical analyses of Molecular Evolution and Demography using Large-scale Sequencing Data

Adamantia Kapopoulou

Evolution can be described as the change of allele frequencies over time. Four forces - mutation, migration, genetic drift, and selection, drive this change. The aim of my thesis was to accurately estimate and differentiate the parameters governing each of ...

EPFL2018

The Demographic History of African Drosophila melanogaster

Jeffrey David Jensen, Adamantia Kapopoulou, Susanne Petra Pfeifer, Stefan Jean Laurent

As one of the most commonly utilized organisms in the study of local adaptation, an accurate characterization of the demographic history of Drosophila melanogaster remains as an important research question. This owes both to the inherent interest in charac ...

OXFORD UNIV PRESS2018

KRAB'n'KAP, DNA methylation and epigenetic memory

Andrea Coluccio

The KZFP/KAP1 (Krüppel associated box zinc finger proteins/KRAB-associated protein 1) complex is a transcriptional repressor that triggers the deposition of heterochromatin (H3K9me3) and DNA methylation. The main targets of the KZFP/KAP1 complex are transp ...

EPFL2017

A heterogeneous evolutionary stable population under assortative matching: Exploring the diversity of preferences

Boris Thurm, Charles Chadi Ayoubi

Recent studies have shown that a population acting not only upon self-interest but also exhibiting some morality preference has an evolutionary advantage. Specifically, in the setting of a symmetric fitness game, a resident population is evolutionary stabl ...

2017

Sexual selection shapes development and maturation rates in Drosophila

Laurent Keller, Brian Dennis Hollis

Explanations for the evolution of delayed maturity usually invoke trade-offs mediated by growth, but processes of reproductive maturation continue long after growth has ceased. Here, we tested whether sexual selection shapes the rate of posteclosion matura ...

Wiley2017

Numerical characterization of bump formation in the runaway electron tail

Joan Decker

Runaway electrons are generated in a magnetized plasma when the parallel electric field exceeds a critical value. For such electrons with energies typically reaching tens of MeV, the Abrahamâ Lorentzâ Dirac (ALD) radiation force, in reaction to the synch ...

Iop Publishing Ltd2016

Hydrology and density feedbacks control the ecology of intermediate hosts of schistosomiasis across habitats in seasonal climates

Andrea Rinaldo, Enrico Bertuzzo, Lorenzo Mari, Natalie Claire Ceperley, Theophile Mande, Francisco Javier Perez Saez, Marino Gatto

We report about field and theoretical studies on the ecology of the aquatic snails (Bulinus spp. and Biomphalaria pfeifferi) that serve as obligate intermediate hosts in the complex life cycle of the parasites causing human schistosomiasis. Snail abundance ...

Natl Acad Sciences2016

Electrochemical Reduction of CO2 Catalyzed by Metal Oxides

Yeonji Oh

A rapidly growing population and industrialization have caused the exploitation of natural resources in keeping with fossil fuels shortage. Due to the combustion of fossil fuels, the concentration of CO2 in the earth's atmosphere, which is a potent greenho ...

EPFL2015

HFI energetic particle effects: characterization, removal, and simulation

Julien Lesgourgues, Fabio Finelli

We describe the detection, interpretation, and removal of the signal resulting from interactions of high energy particles with the Planck High Frequency Instrument (HFI). There are two types of interactions: heating of the 0.1 K bolometer plate; and glitch ...

Edp Sciences S A2014

Linking bacterial population dynamics and nutrient removal in the granular sludge biofilm ecosystem engineered for wastewater treatment

Christof Holliger, David Gregory Weissbrodt, Noam Shani

Intensive nutrient removal from wastewater in anaerobic–aerobic systems using granular sludge should rely on optimal balances at biofilm and microbial ecology levels. This study targets the impacts of reactor characteristics and fluctuations in operation c ...

Blackwell Publishing Ltd, Oxford2014

The antagonistic and synergistic effects of temperature during solar disinfection of synthetic secondary effluent

César Pulgarin, Stefanos Giannakis

A 4-factor, multilevel, full factorial design of 240 experiments was performed in order to investigate the effect of temperature on the inactivation efficiency of spiked Escherichia coli in simulated solar disinfection of a synthetic secondary effluent. Th ...

Elsevier2014

Inferences of Demography and Selection in an African Population of Drosophila melanogaster

Jeffrey David Jensen

It remains a central problem in population genetics to infer the past action of natural selection, and these inferences pose a challenge because demographic events will also substantially affect patterns of polymorphism and divergence. Thus it is imperativ ...

Genetics Society of America2013

Theoretical and Experimental Studies of Dendritic Metacommunities

Francesco Carrara

The present thesis deals with the understanding of the origins and the mechanisms of maintenance of biodiversity in natural landscapes, in particular by identifying key processes that define large-scale patterns of abundance and diversity. Biological commu ...

EPFL2013