Publications related to Long QT syndrome

Compliance-matching vascular grafts with personalization potential

Aortic diseases are characterized by dire prognosis and inadequate diagnosis, owing to their insidious yet lethal nature. Aortopathies, namely aortic aneurysms and dissections, along with certain congenital diseases, might necessitate surgical replacement ...

EPFL2023

Atomic-Level and Surface Structure of Calcium Silicate Hydrate Nanofoils

Karen Scrivener, Paul Bowen, Aslam Kunhi Mohamed, Ziga Casar

Deciphering the calcium silicate hydrate (C-S-H) surface is crucial for unraveling the mechanisms of cement hydration and property development. Experimental observations of C-S-H in cement systems suggest a surface termination which is fundamentally differ ...

AMER CHEMICAL SOC2023

Novel spatiotemporal processing tools for body-surface potential map signals for the prediction of catheter ablation outcome in persistent atrial fibrillation

Jean-Marc Vesin, Adrian Luca, Etienne Pruvot

Background: Signal processing tools are required to efficiently analyze data collected in body-surface-potential map (BSPM) recordings. A limited number of such tools exist for studying persistent atrial fibrillation (persAF). We propose two novel, spatiot ...

FRONTIERS MEDIA SA2022

Active force generation contributes to the complexity of spontaneous activity and to the response to stretch of murine cardiomyocyte cultures

Stéphanie Lacour

Cardiomyocyte cultures exhibit spontaneous electrical and contractile activity, as in a natural cardiac pacemaker. In such preparations, beat rate variability exhibits features similar to those of heart rate variability in vivo. Mechanical deformations and ...

WILEY2022

Hardware-oriented pruning and quantization of Deep Learning models to detect life-threatening arrhythmias

Alexandre Schmid, Lizeth Gonzalez Carabarin

Wearable solutions based on Deep Learning (DL) for real-time ECG monitoring are a promising alternative to detect life-threatening arrhythmias. However, DL models suffer of a large memory footprint, which hampers their adoption in portable technologies. Th ...

IEEE2021

POD-Enhanced Deep Learning-Based Reduced Order Models for the Real-Time Simulation of Cardiac Electrophysiology in the Left Atrium

Alfio Quarteroni, Andrea Manzoni

The numerical simulation of multiple scenarios easily becomes computationally prohibitive for cardiac electrophysiology (EP) problems if relying on usual high-fidelity, full order models (FOMs). Likewise, the use of traditional reduced order models (ROMs) ...

FRONTIERS MEDIA SA2021

Association of Heart Rate Variability With Silent Brain Infarcts in Patients With Atrial Fibrillation

Jean-Marc Vesin, Vincent Schlageter

Purpose: Silent brain infarcts (SBI) are frequently detected in patients with atrial fibrillation (AF), but it is unknown whether SBI are linked to autonomic dysfunction. We aimed to explore the association of autonomic dysfunction with SBI in AF patients. ...

FRONTIERS MEDIA SA2021

ECG-Based Indices to Characterize Persistent Atrial Fibrillation Before and During Stepwise Catheter Ablation

Jean-Marc Vesin, Adrian Luca, Etienne Pruvot

Background: Consistently successful patient outcomes following catheter ablation (CA) for treatment of persistent atrial fibrillation (pers-AF) remain elusive. We propose an electrocardiogram (ECG) analysis designed to (1) refine selection of patients most ...

2021

Automatic 12-lead ECG Classification Using a Convolutional Network Ensemble

Manoel Horta Ribeiro

The 12-lead electrocardiogram (ECG) is a major diagnostic test for cardiovascular diseases and enhanced automated analysis tools might lead to more reliable diagnosis and improved clinical practice. Deep neural networks are models composed of stacked trans ...

IEEE2020

Modular Design and Optimization of Biomedical Applications for Ultra-Low Power Heterogeneous Platforms

David Atienza Alonso, Miguel Peon Quiros, Simone Machetti, Luca Benini, Benoît Walter Denkinger, Elisabetta De Giovanni, Fabio Montagna

In the last years, remote health monitoring is becoming an essential branch of health care with the rapid development of wearable sensors technology. To meet the demand of new more complex applications and ensuring adequate battery lifetime, wearable senso ...

2020

Robust ECG Denoising for eHealth Applications

Guglielmo Frigo

Portable monitoring devices have provided an important cost-effective solution in the development of eHealth applications, providing opportunities for population-wide promotion of physical activity. Monitoring heart profile parameters during extensive acti ...

IEEE2018

Signal processing techniques for cardiovascular monitoring applications using conventional and video-based photoplethysmography

Sibylle Fallet

Photoplethysmography (PPG)-based monitoring devices will probably play a decisive role in healthcare environment of the future, which will be preventive, predictive, personalized and participatory. Indeed, this optical technology presents several practical ...

EPFL2018

A modular low-complexity ECG delineation algorithm for real-time embedded systems

David Atienza Alonso, Francisco Javier Rincon Vallejos, Roman Hermida Correa

This work presents a new modular and lowcomplexity algorithm for the delineation of the different ECG waves (QRS, P and T peaks, onsets and end). Involving a reduced number of operations per second and having a small memory footprint, this algorithm is int ...

2018

Extraction of QRS fiducial points from the ECG using adaptive mathematical morphology

Jean-Marc Vesin, Sasan Yazdani

QRS complex detection in the electrocardiogram (ECG) has been extensively investigated over the last two decades. Still, some issues remain pending due to the diversity of QRS complex shapes and various perturbations, notably baseline drift. This is especi ...

Academic Press Inc Elsevier Science2016

Study of the impact of electrical heterogeneities in the right and left atrium on atrial fibrillation perpetuation

Jean-Marc Vesin, Adrian Luca, Vincent Jacquemet

Introduction: Electrical heterogeneity in the atria has been consistently linked with the initiation and perpetuation of atrial fibrillation (AF). The present model-based study investigated the contribution of action potential duration (APD) heterogeneitie ...

Oxford Univ Press2016

Method for detecting abnormalities in an electrocardiogram

David Atienza Alonso, Giovanni Ansaloni, Francisco Javier Rincon Vallejos, Ruben Braojos Lopez, Srinivasan Murali

A method for classification of ECG beats into normal and different categories of abnormal beats. The method comprises the following steps, performed on a computing platform: a. performing a training phase comprising taking as an input one or more ECG beats ...

2015

Finite element and finite volume-element simulation of pseudo-ECGs and cardiac alternans

Alfio Quarteroni, Ricardo Esteban Ruiz Baier

In this paper, we are interested in the spatio-temporal dynamics of the transmembrane potential in paced isotropic and anisotropic cardiac tissues. In particular, we observe a specific precursor of cardiac arrhythmias that is the presence of alternans in t ...

Wiley-Blackwell2015

Intermittent Atrial Tachycardia Promotes Repolarization Alternans and Conduction Slowing During Rapid Rates, and Increases Susceptibility to Atrial Fibrillation in a Free-Behaving Sheep Model

Jean-Marc Vesin, Florian Jousset, Etienne Pruvot

Repolarization Alternans and Atrial Remodeling Introduction Paroxysmal atrial fibrillation (AF) may be triggered by intermittent atrial tachycardia, and ultimately lead to persistent AF. However, the mechanisms by which intermittent atrial tachycardia prom ...

Wiley-Blackwell2014

Measures of Right Atrial Organization as a Mean to Select Candidates for Sinus Rhythm Restoration by Catheter Ablation

Jean-Marc Vesin, Andréa Buttu, Etienne Pruvot

Stepwise catheter ablation (step-CA) can terminate long-standing persistent atrial fibrillation (LS-pAF) within the left atrium (LA) or may require additional right atrial (RA) ablation. Intracardiac organization indices such as AF cycle length (AFCL) have ...

2013

Adaptive frequency tracking of the baseline ECG identifies the site of atrial fibrillation termination by catheter ablation

Jean-Marc Vesin, Andréa Buttu, Jérôme Sébastien Van Zaen, Etienne Pruvot

Multiple organization indices have been used to predict the outcome of stepwise catheter ablation in long-standing persistent atrial fibrillation (AF), however with limited success. Our study aims at developing innovative organization indices from baseline ...

Elsevier Sci Ltd2013