Concept

Cysteine protease

Related lectures (12)

Explores enzyme catalytic strategies, including proteases and carbonic anhydrase, inhibition mechanisms, and specificity of serine proteases.

Cyclic Peptides and Macrocycles

Explores cyclic peptides and macrocycles, their applications in drug development, and the role of bicyclic peptides in targeting specific proteins.

Post-Translational Modifications and Folding in the ER

Explores post-translational modifications and folding processes in the endoplasmic reticulum, using examples like the influenza virus and protein misfolding diseases.

Enzymes: Catalytic Strategies

Explores enzymes' catalytic strategies, including proteases and carbonic anhydrase, specificity, and pH influence on catalysis.

Enzymes: Basic Concepts and Kinetics

Delves into enzymes' basic concepts, kinetics, and catalytic strategies for reaction acceleration.

Inhibitor Design & Analysis

Covers the design and analysis of inhibitors for next-generation covalent drugs, focusing on target engagement and the importance of cysteine targeting.

Inhibitor Design & Analysis

Covers the fundamentals of inhibitor design and analysis, emphasizing the importance of targeting cysteine residues.

Invasion & Metastasis: Mechanisms and Implications

Explores the mechanisms of cancer invasion and metastasis, emphasizing the critical role of cell adhesion, signaling rewiring, and organotropism.

Automation in Protein Identification: Techniques and Workflows

Covers the automation of protein identification using liquid chromatography and mass spectrometry techniques.

Protein Translocation in the Endoplasmic Reticulum

Explains protein translocation in the endoplasmic reticulum, focusing on signal peptides and co-translational transfer across the ER membrane.

Activity-based Protein Profiling: Druggable Sites Identification

Explores Activity-based Protein Profiling for druggable site identification and strategies to minimize off-target reactivity of covalent inhibitors.

Optogenetics: Probing Neuronal Activity with Light

Explores optogenetics, genetically-encoded tools, and clinical applications in probing neuronal activity with light.