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Related publications (30)

Bioelectronic medicine for the autonomic nervous system: clinical applications and perspectives

Silvestro Micera, Ivo Strauss

Bioelectronic medicine (BM) is an emerging new approach for developing novel neuromodulation therapies for pathologies that have been previously treated with pharmacological approaches. In this review, we will focus on the neuromodulation of autonomic nerv ...

IOP PUBLISHING LTD2021

Tutorial: a computational framework for the design and optimization of peripheral neural interfaces

Silvestro Micera, Simone Romeni, Giacomo Valle

Peripheral neural interfaces have been successfully used in the recent past to restore sensory-motor functions in disabled subjects and for the neuromodulation of the autonomic nervous system. The optimization of these neural interfaces is crucial for ethi ...

NATURE RESEARCH2020

Anatomically and functionally distinct thalamocortical inputs to primary and secondary mouse whisker somatosensory cortices

Carl Petersen, Georgios Foustoukos, Sami El-Boustani, Berat Semihcan Sermet

Subdivisions of mouse whisker somatosensory thalamus project to cortex in a region-specific and layer-specific manner. However, a clear anatomical dissection of these pathways and their functional properties during whisker sensation is lacking. Here, we us ...

Nature Publishing Group2020

Neural signal recording and processing in somatic neuroprosthetic applications. A review

Silvestro Micera, Stanisa Raspopovic, Andrea Cimolato

Neurointerfaces have acquired major relevance as both rehabilitative and therapeutic tools for patients with spinal cord injury, limb amputations and other neural disorders. Bidirectional neural interfaces are a key component for the functional control of ...

ELSEVIER2020

Refinements of hybrid neurophysical volume conductor models and application to study epidural electrical stimulation of the cervical spinal cord

Nathan Antoine Greiner

After spinal cord injury (SCI), the communication between the brain and spinal neural circuits below the lesion is disrupted, leading to paralysis. Epidural electrical stimulation (EES) of the lumbosacral spinal cord has been shown to restore locomotion an ...

EPFL2020

Characterization of multi-channel intraneural stimulation in transradial amputees

Silvestro Micera, Stanisa Raspopovic, Fiorenzo Artoni, Francesco Maria Petrini, Edoardo D'Anna, Pablo Garcia del Valle, Ivo Strauss, Giacomo Valle

Although peripheral nerve stimulation using intraneural electrodes has been shown to be an effective and reliable solution to restore sensory feedback after hand loss, there have been no reports on the characterization of multi-channel stimulation. A deepe ...

Springer Nature2019

Low vagal tone in two rat models of psychopathology involving high or low corticosterone stress responses

Maria del Carmen Sandi Perez, Damien Sébastien Huzard, Jocelin Grosse, Sriparna Ghosal

The two stress-responsive physiological systems, autonomic nervous system (ANS) and hypothalamus-pituitary-adrenal (HPA) axis exert complementary and interrelated actions in the organism. Individuals that suffer stress-related psychopathologies frequently ...

2019

Schwann cells ER-associated degradation contributes to myelin maintenance in adult nerves and limits demyelination in CMT1B mice

Maurizio Molinari, Francesca Bianchi

In the peripheral nervous system (PNS) myelinating Schwann cells synthesize large amounts of myelin protein zero (P0) glycoprotein, an abundant component of peripheral nerve myelin. In humans, mutations in P0 cause the demyelinating Charcot-Marie-Tooth 1B ...

2019

Microchannel-based technologies for nerve interfacing

Sandra Gribi

Biomedical technologies in neuroprosthetics are made to restore or replace functions from the nervous system, as well as alleviate pathological conditions. Peripheral nerve interfaces use neuromodulatory techniques to inhibit pain or depression, prevent ep ...

EPFL2019

Biomedical optical techniques for intracochlear cellular imaging

Marilisa Romito

Imaging the inner ear microanatomy is of great importance for the assessment of the state of the cells responsible for sound detection. Hearing disorders are mainly due to a malfunction of the cochlea, the bone containing the cells inside the inner ear. Un ...

EPFL2019

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