Phagocyte

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Related publications (31)

Immune serum-activated human macrophages coordinate with eosinophils to immobilize Ascaris suum larvae

Nicola Harris, Beatrice Volpe, Julia Esser-von Bieren, Tiffany Babette Angélique Bouchery, Kathleen Shah

Helminth infection represents a major health problem causing approximately 5 million disability-adjusted life years worldwide. Concerns that repeated anti-helminthic treatment may lead to drug resistance render it important that vaccines are developed but ...

WILEY2020

Hookworms Evade Host Immunity by Secreting a Deoxyribonuclease to Degrade Neutrophil Extracellular Traps

Arne Seitz, Romain Guiet, Nicola Harris, Beatrice Volpe, Tiffany Babette Angélique Bouchery, Kathleen Shah, Mati André Marie Moyat, Manuel Kulagin

Hookworms cause a major neglected tropical disease, occurring after larvae penetrate the host skin. Neutrophils are phagocytes that kill large pathogens by releasing neutrophil extracellular traps (NETs), but whether they target hookworms during skin infec ...

CELL PRESS2020

Virus-Mediated Cell-Cell Fusion

Lucie Josepha Marie Bracq

Cell-cell fusion between eukaryotic cells is a general process involved in many physiological and pathological conditions, including infections by bacteria, parasites, and viruses. As obligate intracellular pathogens, viruses use intracellular machineries ...

2020

Two Nimrod receptors, NimC1 and Eater, synergistically contribute to bacterial phagocytosis in Drosophila melanogaster

Bruno Lemaitre, Jan Paul Dudzic, Elodie Julie Virginie Ramond, Andrew Jonathan Bretscher, Claudia Melcarne

Eater and NimC1 are transmembrane receptors of the Drosophila Nimrod family, specifically expressed in haemocytes, the insect blood cells. Previous ex vivo and in vivoRNAi studies have pointed to their role in the phagocytosis of bacteria. Here, we have cr ...

2019

Phagocytosis in Drosophila: From molecules and cellular machinery to physiology

Bruno Lemaitre, Claudia Melcarne

Phagocytosis is an evolutionarily conserved mechanism that plays a key role in both host defence and tissue homeostasis in multicellular organisms. A range of surface receptors expressed on different cell types allow discriminating between self and non-sel ...

2019

Adult Drosophila Lack Hematopoiesis but Rely on a Blood Cell Reservoir at the Respiratory Epithelia to Relay Infection Signals to Surrounding Tissues

Bruno Lemaitre, Elodie Julie Virginie Ramond

The use of adult Drosophila melanogaster as a model for hematopoiesis or organismal immunity has been debated. Addressing this question, we identify an extensive reservoir of blood cells (hemocytes) at the respiratory epithelia (tracheal air sacs) of the t ...

Cell Press - Elsevier2019

Lysozyme-Induced Transcriptional Regulation of TNF-alpha Pathway Genes in Cells of the Monocyte Lineage

Paul Joseph Dyson, Romain Hamelin, Florence Armand, Isabelle Mireille Claude Schepens, Gianni Sava

Lysozyme is one of the most important anti-bacterial effectors in the innate immune system of animals. Besides its direct antibacterial enzymatic activity, lysozyme displays other biological properties, pointing toward a significant anti-inflammatory effec ...

2019

Combining landscape genomics and ecological modelling to investigate local adaptation of indigenous Ugandan cattle to East Coast fever

Stéphane Joost, Estelle Rochat, Elia Vajana

East Coast fever (ECF) is a fatal sickness affecting cattle populations of eastern, central, and southern Africa. The disease is transmitted by the tick Rhipicephalus appendiculatus, and caused by the protozoan Theileria parva parva, which invades host lym ...

2018

Combining Landscape Genomics and Ecological Modelling to Investigate Local Adaptation of Indigenous Ugandan Cattle to East Coast Fever

Stéphane Joost, Estelle Rochat, Elia Vajana

2018

A microfluidic cell-trapping device to study dynamic host-microbe interactions at the single-cell level

John McKinney, Matthieu Jean-Hubert Delincé, Chiara Toniolo

Single-cell imaging of host-microbe interactions over time is impeded by cellular motility because the cells under scrutiny tend to migrate out of the imaging field. To overcome this technical challenge, we developed a microfluidic platform for imaging hun ...

ELSEVIER ACADEMIC PRESS INC2018

Perivascular macrophages in health and disease

Michele De Palma

Macrophages are a heterogeneous group of cells that are capable of carrying out distinct functions in different tissues, as well as in different locations within a given tissue. Some of these tissue macrophages lie on, or close to, the outer (abluminal) su ...

Nature Publishing Group2018

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