Publications related to Cardiomyopathy

The role of computational methods in cardiovascular medicine: a narrative review

Alfio Quarteroni, Luca Dede', Christian Vergara, Stefano Pagani

Background and Objective: Computational models of the cardiovascular system allow for a detailed and quantitative investigation of both physiological and pathological conditions, thanks to their ability to combine clinical-possibly patient-specific-data wi ...

Ame Publishing Company2024

Blood Flow to the Spleen is Altered in a Mouse Model of Spinal Muscular Atrophy

Bernard Schneider

Spinal muscular atrophy (SMA) is a neuromuscular disorder affecting young children. While pre-clinical models of SMA show small spleens, the same is not true in humans. Here, we show by doppler ultrasonography decreased splenic blood flow in Smn(2B/-) mice ...

2020

Metabolic fingerprints discriminating severity of acute ischemia using in vivo high-field H-1 magnetic resonance spectroscopy

Mario Gaetano Lepore, Hongxia Lei, Lara Buscemi Estefanell

Despite the improving imaging techniques, it remains challenging to produce magnetic resonance (MR) imaging fingerprints depicting severity of acute ischemia. The aim of this study was to evaluate the potential of the overall high-field H-1 MR Spectroscopy ...

Wiley-Blackwell2020

An image-based computational hemodynamics study of the Systolic Anterior Motion of the mitral valve

Alfio Quarteroni, Luca Dede', Christian Vergara, Marco Fedele

Systolic Anterior Motion (SAM) of the mitral valve - often associated with Hypertrophic Obstructive Cardiomyopathy (HOCM) - is a cardiac pathology in which a functional subaortic stenosis is induced during systole by the mitral leaflets partially obstructi ...

PERGAMON-ELSEVIER SCIENCE LTD2020

Impact of aerobic exercise type on blood flow, muscle energy metabolism, and mitochondrial biogenesis in experimental lower extremity artery disease

Rolf Gruetter, Carole Poitry-Yamate

Exercise training (ET) is recommended for lower extremity artery disease (LEAD) management. However, there is still little information on the hemodynamic and metabolic adaptations by skeletal muscle with ET. We examined whether hindlimb perfusion/vasculari ...

Nature Research2020

Hierarchical Cardiac-Rhythm Classification Based on Electrocardiogram Morphology

David Atienza Alonso, Amir Aminifar, Elisabetta De Giovanni, Dionisije Sopic

Atrial Fibrillation (AF) is a type of cardiac arrhythmia that significantly increases the risk of stroke and heart failure. In general, in the case of patients affected by AF, their electrocardiogram (ECG) shows a typical pattern of irregular RR intervals ...

2017

Method for detecting abnormalities in an electrocardiogram

David Atienza Alonso, Giovanni Ansaloni, Francisco Javier Rincon Vallejos, Ruben Braojos Lopez, Srinivasan Murali

A method for classification of ECG beats into normal and different categories of abnormal beats. The method comprises the following steps, performed on a computing platform: a. performing a training phase comprising taking as an input one or more ECG beats ...

2015

Early Classification of Pathological Heartbeats on Wireless Body Sensor Nodes

David Atienza Alonso, Giovanni Ansaloni, Ruben Braojos Lopez, Ivan Beretta

Smart Wireless Body Sensor Nodes (WBSNs) are a novel class of unobtrusive, battery-powered devices allowing the continuous monitoring and real-time interpretation of a subject's bio-signals, such as the electrocardiogram (ECG). These low-power platforms, w ...

MDPI2014

A Methodology for Embedded Classification of Heartbeats Using Random Projections

David Atienza Alonso, Giovanni Ansaloni, Ruben Braojos Lopez

Smart Wireless Body Sensor Nodes (WBSNs) are a novel class of unobtrusive, battery-powered devices allowing the continuous monitoring and real-time interpretation of a subject’s bio-signals. One of its most relevant applications is the acquisition and anal ...

2013

TIE2-expressing monocytes/macrophages regulate revascularization of the ischemic limb

Michele De Palma, Daniela Biziato

A third of patients with critical limb ischemia (CLI) will eventually require limb amputation. Therapeutic neovascularization using unselected mononuclear cells to salvage ischemic limbs has produced modest results. The TIE2-expressing monocytes/macrophage ...

Wiley-Blackwell2013

Selective in vivo visualization of immune-cell infiltration in a mouse model of autoimmune myocarditis by fluorine-19 cardiac magnetic resonance

Ruud van Heeswijk

Background- The goal of this study was to characterize the performance of fluorine-19 ((19)F) cardiac magnetic resonance (CMR) for the specific detection of inflammatory cells in a mouse model of myocarditis. Intravenously administered perfluorocarbons are ...

2013

Cardiac and Skeletal Muscle Defects in a Mouse Model of Human Barth Syndrome

Richardus Houtkooper

Barth syndrome is an X-linked genetic disorder caused by mutations in the tafazzin (taz) gene and characterized by dilated cardiomyopathy, exercise intolerance, chronic fatigue, delayed growth, and neutropenia. Tafazzin is a mitochondrial transacylase requ ...

2011

Harmonic frequency tracking algorithm for predicting the success of pharmacological cardioversion of atrial fibrillation

Jean-Marc Vesin, Andréa Buttu, Laurent Renaud Uldry, Jérôme Sébastien Van Zaen, Lukas Kappenberger

Purpose: Non-invasively predicting the success of pharmacological cardioversion for patients with atrial fibrillation (AF) would be of great interest in clinical settings. In this study, an adaptive algorithm for tracking fundamental and harmonic component ...

2011

Fate of undifferentiated mouse embryonic stem cells within the rat heart: role of myocardial infarction and immune suppression

Jian Li, Qing He

It has recently been suggested that the infarcted rat heart microenvironment could direct pluripotent mouse embryonic stem cells to differentiate into cardiomyocytes through an in situ paracrine action. To investigate whether the heart can function as a ca ...

2009

Myocardial perfusion assessment by use of system identification method in a one-compartment model

Philippe Thévenaz, Michel Kocher

Cardiovascular magnetic resonance has been shown to provide high data quality for myocardial perfusion assessment However, to analyze the perfusion data, some signal processing and modeling is needed to correct for motion related artifacts and limited spat ...

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