Publications related to Peripheral artery disease

Quantitative T2 Mapping of Acute Pancreatitis

Background: Quantification of the T2 signal by means of T2 mapping in acute pancreatitis (AP) has the potential to quantify the parenchymal edema. Quantitative T2 mapping may overcome the limitations of previously reported scoring systems for reliable asse ...

Wiley2024

HTATIP2 regulates arteriogenic activity in monocytes from patients with limb ischemia

Michele De Palma, Mario Leonardo Squadrito

Use of autologous cells isolated from elderly patients with multiple comorbidities may account for the modest efficacy of cell therapy in patients with chronic limb threatening ischemia (CLTI). We aimed to determine whether proarteriogenic monocyte/macroph ...

Amer Soc Clinical Investigation Inc2023

Leukocyte Count and Coronary Artery Disease Events in People With Human Immunodeficiency Virus: A Longitudinal Study

Jacques Fellay, Christian Axel Wandall Thorball

Leukocyte count is associated with coronary artery disease (CAD) events in the general population. Here we show that leukocytes are independently associated with CAD events in people with HIV in Switzerland, after adjusting for traditional and HIVrelated r ...

OXFORD UNIV PRESS INC2023

Quantification of the Phenomena Affecting Reflective Arterial Photoplethysmography

Nikolaos Stergiopoulos, Georgios Rovas, Vasiliki Bikia

Photoplethysmography (PPG) is a widely emerging method to assess vascular health in humans. The origins of the signal of reflective PPG on peripheral arteries have not been thoroughly investigated. We aimed to identify and quantify the optical and biomecha ...

MDPI2023

Combining European and US risk prediction models with polygenic risk scores to refine cardiovascular prevention: the CoLaus|PsyCoLaus Study

Jacques Fellay, Christian Axel Wandall Thorball, Stéphane Fournier, Roxane De La Harpe

Lay Summary The aim of this study is to determine whether using polygenic risk scores improves the prediction of atherosclerotic cardiovascular disease risk when combined with clinical scores currently recommended by European and US guidelines on cardiovas ...

OXFORD UNIV PRESS2023

Sodium thiosulfate, a source of hydrogen sulfide, stimulates endothelial cell proliferation and neovascularization

Georges Wagnières, Jaroslava Joniová, Séverine Marguerite Urfer

Therapies to accelerate vascular repair are currently lacking. Pre-clinical studies suggest that hydrogen sulfide (H2S), an endogenous gasotransmitter, promotes angiogenesis. Here, we hypothesized that sodium thiosulfate (STS), a clinically relevant source ...

FRONTIERS MEDIA SA2022

Polygenic Risk Scores for Prediction of Subclinical Coronary Artery Disease in Persons Living With HIV: The Swiss HIV Cohort Study

Jacques Fellay, Christian Axel Wandall Thorball

Background. In people living with human immunodeficiency virus (HIV) (PLWH), individual polygenic risk scores (PRSs) are associated with coronary artery disease (CAD) events. Whether PRSs are associated with subclinical CAD is unknown. ...

OXFORD UNIV PRESS INC2022

Coronary Artery Disease-Associated and Longevity-Associated Polygenic Risk Scores for Prediction of Coronary Artery Disease Events in Persons Living With Human Immunodeficiency Virus: The Swiss HIV Cohort Study

Jacques Fellay, Christian Axel Wandall Thorball

Background: Coronary artery disease (CAD) is in part genetically determined. Aging is accentuated in people with human immunodeficiency virus (HIV) (PLWH). It is unknown whether genetic CAD event prediction in PLWH is improved by applying individual polyge ...

OXFORD UNIV PRESS INC2021

Considerations for analysis of endothelial shear stress and strain in FSI models of atherosclerosis

Lydia Aslanidou, Fotios Savvopoulos

Atherosclerosis is a lipid driven chronic inflammatory disease that is characterized by the formation of plaques at predilection sites. These predilection sites (side branches, curved segments, and bifurcations) have often been associated with disturbed sh ...

ELSEVIER SCI LTD2021

Distinct types of plexiform lesions identified by synchrotron-based phase-contrast micro-CT

Goran Lovric

In pulmonary arterial hypertension, plexiform lesions are associated with severe arterial obstruction and right ventricular failure. Exploring their structure and position is crucial for understanding the interplay between hemodynamics and vascular remodel ...

AMER PHYSIOLOGICAL SOC2021

Long noncoding RNA SNHG12 integrates a DNA-PK-mediated DNA damage response and vascular senescence

Johan Auwerx, Norman Lionel Moullan, Lei Chen

Long noncoding RNAs (lncRNAs) are emerging regulators of biological processes in the vessel wall; however, their role in atherosclerosis remains poorly defined. We used RNA sequencing to profile lncRNAs derived specifically from the aortic intima of Ldlr(- ...

AMER ASSOC ADVANCEMENT SCIENCE2020

Impact of aerobic exercise type on blood flow, muscle energy metabolism, and mitochondrial biogenesis in experimental lower extremity artery disease

Rolf Gruetter, Carole Poitry-Yamate

Exercise training (ET) is recommended for lower extremity artery disease (LEAD) management. However, there is still little information on the hemodynamic and metabolic adaptations by skeletal muscle with ET. We examined whether hindlimb perfusion/vasculari ...

Nature Research2020

On the importance of the nonuniform aortic stiffening in the hemodynamics of physiological aging

Nikolaos Stergiopoulos, Bram Trachet, Vasiliki Bikia, Stamatia Zoi Pagoulatou

Mathematical models of the arterial tree constitute a valuable tool to investigate the hemodynamics of aging and pathology. Rendering such models as patient specific could allow for the assessment of central hemodynamic variables of clinical interest. Howe ...

AMER PHYSIOLOGICAL SOC2019

A systematic review and meta-analysis of the efficacy of aortic anastomotic devices

Nikolaos Stergiopoulos, Dimitrios Schizas

Objective: One of the factors contributing to complications related to open repair of the aorta is the construction of a hand-sewn anastomosis. Aortic anastomotic devices (AADs), such as the intraluminal ringed graft (IRG), and the anastomotic stenting tec ...

MOSBY-ELSEVIER2019

Correlating Twitter Language with Community-Level Health Outcomes

Martin Jaggi, Arno Schneuwly

We study how language on social media is linked to diseases such as atherosclerotic heart disease (AHD), diabetes and various types of cancer. Our proposed model leverages state-of-the-art sentence embeddings, followed by a regression model and clustering, ...

ASSOC COMPUTATIONAL LINGUISTICS-ACL2019

A 1D computer model of the arterial circulation in horses: An important resource for studying global interactions between heart and vessels under normal and pathological conditions

Nikolaos Stergiopoulos, Patrick Segers

Arterial rupture in horses has been observed during exercise, after phenylephrine administration or during parturition (uterine artery). In human pathophysiological research, the use of computer models for studying arterial hemodynamics and understanding n ...

2019

A computational fluid-structure interaction analysis of coronary Y-grafts

Alfio Quarteroni, Christian Vergara

Coronary artery disease is one of the leading causes of death worldwide. The stenotic coronary vessels are generally treated with coronary artery bypass grafts (CABGs), which can be either arterial (internal mammary artery, radial artery) or venous (saphen ...

Elsevier Sci Ltd2017

Numerical modeling of hemodynamics scenarios of patient-specific coronary artery bypass grafts

Alfio Quarteroni, Gianluigi Rozza, Andrea Manzoni, Elena Faggiano

A fast computational framework is devised to the study of several configurations of patient-specific coronary artery bypass grafts. This is especially useful to perform a sensitivity analysis of the hemodynamics for different flow conditions occurring in n ...

Springer Heidelberg2017

Computational study of the risk of restenosis in coronary bypasses

Alfio Quarteroni, Christian Vergara

Coronary artery disease, caused by the buildup of atherosclerotic plaques in the coronary vessel wall, is one of the leading causes of death in the world. For high-risk patients, coronary artery bypass graft is the preferred treatment. Despite overall exce ...

Springer Heidelberg2017

Fast simulations of patient-specific haemodynamics of coronary artery bypass grafts based on a POD-Galerkin method and a vascular shape parametrization

Alfio Quarteroni, Gianluigi Rozza, Andrea Manzoni, Elena Faggiano

In this work a reduced-order computational framework for the study of haemodynamics in three-dimensional patient-specific configurations of coronary artery bypass grafts dealing with a wide range of scenarios is proposed. We combine several efficient algor ...

Elsevier2016