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Related publications (27)

Role of glutathione S-transferases and the mercapturic acid pathway in the biotransformation potential of two zebrafish (Danio rerio) test systems: early life stages and PAC2 cells

Alena Tierbach

Zebrafish (Danio rerio) early life stages provide an important model for chemical risk assessment due to their genetic similarity to humans and the availability of well-established high-throughput techniques. Cells isolated from zebrafish conserve all thes ...

EPFL2020

Strategies to modulate zebrafish collective dynamics with a closed-loop biomimetic robotic system

Francesco Mondada, Alexey Gribovskiy, Frank Bonnet

The objective of this study is to integrate biomimetic robots into small groups of zebrafish and to modulate their collective behaviours. A possible approach is to have the robots behave like sheepdogs. In this case, the robots would behave like a differen ...

2020

STAT3 promotes melanoma metastasis by CEBP-induced repression of the MITF pathway

Friedrich Beermann

Metastatic melanoma is hallmarked by its ability of phenotype switching to more slowly proliferating, but highly invasive cells. Here, we tested the impact of signal transducer and activator of transcription 3 (STAT3) on melanoma progression in association ...

SPRINGERNATURE2021

Deformation-aware Unpaired Image Translation for Pose Estimation on Laboratory Animals

Pascal Fua, Pavan P Ramdya, Helge Jochen Rhodin, Semih Günel, Siyuan Li, Mirela Ostrek

Our goal is to capture the pose of neuroscience model organisms, without using any manual supervision, to be able to study how neural circuits orchestrate behaviour. Human pose estimation attains remarkable accuracy when trained on real or simulated datase ...

2020

Origin and role of the cerebrospinal fluid bidirectional flow in the central canal

François Gallaire, Ludovic Pierre Gustave Keiser

Circulation of the cerebrospinal fluid (CSF) contributes to body axis formation and brain development. Here, we investigated the unexplained origins of the CSF flow bidirectionality in the central canal of the spinal cord of 30 hpf zebrafish embryos and it ...

2020

LC-APCI(-)-MS Determination of 1-Chloro-2,4-dinitrobenzene, a Model Substrate for Glutathione S-Transferases

Kristin Schirmer, Alena Tierbach

1-Chloro-2,4-dinitrobenzene (CDNB) is widely used as a model substrate for measuring the enzyme activity of glutathione S-transferases in toxicity studies and in studies focusing on the metabolic capacity of different test systems. To allow the quantificat ...

AMER CHEMICAL SOC2020

Common Gene Expression Patterns in Environmental Model Organisms Exposed to Engineered Nanomaterials: A Meta-Analysis

Kristin Schirmer, Anze Zupanic

The use of omics is gaining importance in the field of nanoecotoxicology; an increasing number of studies are aiming to investigate the effects and modes of action of engineered nanomaterials (ENMs) in this way. However, a systematic synthesis of the outco ...

AMER CHEMICAL SOC2020

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