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Related publications (31)

Tailoring the Mechanical Properties of Tissue Engineering Scaffolds made from Decellularized Cartilage

Jens Antons

Due to its limited regeneration capacity, articular cartilage defects are considered a frequent clinical problem. Initial cartilage defects, if left untreated, will progress in severity over time and can eventually lead to degenerative joint diseases such ...

EPFL2019

Synchrotron MicroCT Reveals the Potential of the Dual Contrast Technique for Quantitative Assessment of Human Articular Cartilage Composition

Goran Lovric

Dual contrast micro computed tomography (CT) shows potential for detecting articular cartilage degeneration. However, the performance of conventional CT systems is limited by beam hardening, low image resolution (full-body CT), and long acquisition times ( ...

2020

Simultaneous Quantitation of Cationic and Non-ionic Contrast Agents in Articular Cartilage Using Synchrotron MicroCT Imaging

Goran Lovric

Early diagnosis of acute cartilage injuries enables monitoring of disease progression and improved treatment option planning to prevent post-traumatic osteoarthritis. In contrast-enhanced computed tomography (CECT), the changes in cationic agent diffusion ...

Nature Research2019

Variable Stiffness Spring Actuators for Low-Energy-Cost Human Augmentation

Salil Apte

Theoretical studies suggest and experimental evidence confirms that maintaining and changing human joint stiffness by coactivated antagonistic muscles are metabolically expensive, even if muscles do not perform net mechanical work. Based on this observatio ...

2019

Design and characterization of variable stiffness structural joints

Gennaro Senatore

This paper presents design and characterization of a new type of structural joint which can vary its stiffness through actuation. Stiffness variation is employed to control the dynamic response of frame structures equipped with such joints. The joint is ma ...

2019

Triple Contrast CT Method Enables Simultaneous Evaluation of Articular Cartilage Composition and Segmentation

Goran Lovric

Early degenerative changes of articular cartilage are detected using contrast-enhanced computed tomography (CT) with a cationic contrast agent (CA). However, cationic CA diffusion into degenerated cartilage decreases with proteoglycan depletion and increas ...

2020

Characterization of variable stiffness joints for adaptive structures

Gennaro Senatore

This paper presents a new strategy to control the structure dynamic response via a shift of the natural frequencies obtained through using variable stiffness joints. The joints are made of shape memory polymers and are fabricated through 3D printing. Stiff ...

Taylor & Francis2019

Modeling knee osteoarthritis pathophysiology using an integrated joint system (IJS): a systematic review of relationships among cartilage thickness, gait mechanics, and subchondral bone mineral density

Julien Favre, Brigitte Jolles-Haeberli

Objective: To introduce an integrated joint system (IJS) model of joint health and osteoarthritis (OA) pathophysiology through a systematic review of the cross-sectional relationships among three knee properties (cartilage thickness, gait mechanics, and su ...

ELSEVIER SCI LTD2018

Depth-dependent mechanical properties of human articular cartilage obtained by indentation measurements

Pierre-Etienne Bourban, Lee Ann Laurent-Applegate, Matteo Gregorio Modesto Marascio, Robin Martin, Jens Antons

Emerging 3D printing technology permits innovative approaches to manufacture cartilage scaffolds associated with layer-by-layer mechanical property adaptation. However, information about gradients of mechanical properties in human articular cartilage is li ...

2018

Quantitative regional and sub-regional analysis of femoral and tibial subchondral bone mineral density (sBMD) using computed tomography (CT): comparison of non-osteoarthritic (OA) and severe OA knees

Julien Favre, Brigitte Jolles-Haeberli

Objective: This study aimed to compare subchondral bone mineral density (sBMD) between non-radiographic osteoarthritic (OA) and medial femorotibial OA knees, using computed tomography (CT). Design: CT exams from 16 non-radiographic OA (KL grade < 2) and 16 ...

Elsevier Sci Ltd2017

A semi-automated quantitative CT method for measuring rotator cuff muscle degeneration in shoulders with primary osteoarthritis

Alexandre Terrier, Alain Farron, Julien Ston, Antoine Dewarrat

Background: Rotator cuff muscle degeneration is an important parameter to consider when planning shoulder arthroplasty. Hypothesis: We hypothesized that rotator cuff muscle degeneration is correlated with scapulohumeral subluxation in patients planned for ...

Elsevier Masson2017

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