Publications related to Opioid

A Stand-Alone Augmented Reality Intervention for Chronic Pain using Embodied Systolic Stimulation

Sylvain Cardin, Andrea Serino, Robert Leeb, Oliver Alan Kannape, Skander Mensi, Fabien Bourban, Alexis Dorier

Chronic pain presents a tremendous personal, societal, and financial burden. Treatment options are often limited to managing symptoms as opposed to treating the causes, and the consequences of pharmacological treatments can be immensely harmful as evidence ...

IEEE2023

Enhancing the Signaling of GPCRs via Orthosteric Ions

Horst Vogel, Shuguang Yuan

G protein-coupled receptors play essential roles in cellular processes such as neuronal signaling, vision, olfaction, tasting, and metabolism. As GPCRs are the most important drug targets, understanding their interactions with ligands is of utmost importan ...

AMER CHEMICAL SOC2020

Cognitive neuroprosthetics for investigating and restoring body perception

Marco Solcà

Our brain constantly receives and integrates a flow of multisensory bodily inputs that are responsible for the way our body is represented and consciously experienced. However, in some pathological conditions, patients might experience altered perceptions ...

EPFL2019

Gas-phase structures reflect the pain-relief potency of enkephalin peptides

Oleg Boyarkine, Vladimir Kopysov, Aleksandr Pereverzev

We use cold ion spectroscopy and quantum-chemical computations to solve the structures of opioid peptides enkephalins in the gas phase. The derived structural parameters clearly correlate with the known pharmacological efficiency of the studied drugs, sugg ...

2019

IoT Bio-Electronic Multi-Panel Device for On-line Monitoring of Anaesthesia Delivery

Francesca Stradolini

After a failure of "One-Size-Fits-All" approach on traditional treatment of diseases, the age of multi-faceted personalized medicine came into being for tailoring therapy to get the best response in the highest safety margin. Personalized drug dosage is on ...

EPFL2018

Heartbeat-enhanced immersive virtual reality to treat complex regional pain syndrome

Olaf Blanke, Marco Solcà, Bruno Herbelin, Andrea Serino, Roberta Ronchi, Javier Bello Ruiz, Thomas Schmidlin

OBJECTIVES: To develop and test a new immersive digital technology for complex regional pain syndrome (CRPS) that combines principles from mirror therapy and immersive virtual reality and the latest research from multisensory body processing. METHODS: In t ...

2018

Raspberry-Pi based system for propofol monitoring

Sandro Carrara, Francesca Stradolini, Danilo Demarchi, Tugba Kilic, Abuduwaili Tuoheti

Induction of anesthesia with propofol is a largely adopted technique in hospital environments. The correct dosage of this compound is essential to avoid under- or over-anesthesia that may result in serious side-effects. Therefore, in clinical settings, lon ...

ELSEVIER SCIENCE BV2018

Designing Safer Analgesics via mu-Opioid Receptor Pathways

Shuguang Yuan, Jianing Li

Pain is both a major clinical and economic problem, affecting more people than diabetes, heart disease, and cancer combined. While a variety of prescribed or over-the-counter (OTC) medications are available for pain management, opioid medications, especial ...

Elsevier Science London2017

Computational design of environmental sensors for the potent opioid fentanyl

Kai Johnsson, Luc Reymond

We describe the computational design of proteins that bind the potent analgesic fentanyl. Our approach employs a fast docking algorithm to find shape complementary ligand placement in protein scaffolds, followed by design of the surrounding residues to opt ...

Elife Sciences Publications Ltd2017

Stress, glucocorticoid receptor and social behaviors

Peripuberty, comprising childhood and adolescence, constitutes an important time window in the brain development and maturation. Exposure to prolonged stress during this period has been shown to increase the risk for the development of psychopathologies la ...

EPFL2017

Resonance Energy Transfer Relates the Gas-Phase Structure and Pharmacological Activity of Opioid Peptides

Oleg Boyarkine, Vladimir Kopysov

Enkephalins are efficient pain-relief drugs that bind to transmembrane opioid receptors. One key structural param- eter that governs the pharmacological activity of these opioid peptides and is typically determined from condensed-phase structures is the di ...

Wiley-Blackwell2016

The Mechanism of Ligand-Induced Activation or Inhibition of - and -Opioid Receptors

Horst Vogel, Shuguang Yuan

G-protein-coupled receptors (GPCRs) are important targets for treating severe diseases. However why certain molecules act as activators whereas others, with similar structures, block GPCR activation, is poorly understood since the same molecule can activat ...

Wiley-Blackwell2015

Intrathecal implants of bovine chromaffin cells alleviate mechanical allodynia in a rat model of neuropathic pain

Patrick Aebischer

Intrathecal implants of adrenal chromaffin cells are known to release analgesic substances such as catecholamines and opioid peptides. In the present study, bovine chromaffin cells were encapsulated in a permselective polymer membrane which protects the ce ...

1998

Immunoisolated xenogenic chromaffin cell therapy for chronic pain. Initial clinical experience

Patrick Aebischer, Julien Favre

BACKGROUND: Chromaffin cells from the adrenal gland secrete a mixture of compounds that have a strong analgesic effect, especially when administered intrathecally. Many studies in animal models have shown that discordant xenogeneic cell isolates, including ...

1996