Lectures related to Tyrosine kinase

Protein Phosphorylation: Mechanisms & Regulation

Explores protein phosphorylation, detailing common modifications like acetylation and ubiquitination, kinase specificity, and activation mechanisms.

Receptor Tyrosine Kinases: Signalling and Regulation

Explores the activation, signalling cascades, and regulatory mechanisms of receptor tyrosine kinases, with a focus on disease implications and therapeutic strategies.

Posttranslational Modifications: Phosphorylation and Protein Phosphatases

Covers posttranslational modifications, focusing on phosphorylation and protein phosphatases, and explains kinase specificity assays and the optimal phosphorylation consensus.

SEGREGATION of KINETIC REACTIVITY & BINDING AFFINITY

The paper focuses on the importance of reversible interactions to potency and mechanisms of drug resistance.

Kinase Inhibitors: Types and Mechanisms

Explores kinase inhibitors, their types, mechanisms, and experimental evaluation, emphasizing the significance of covalent drugs in modern pharmaceutical research.

Tyrosine Kinases & Ras Signaling

Explores tyrosine kinases, Ras activation, lipid signaling, cancer implications, and signal transduction in cells.

Sustained Proliferation: Signaling Pathways and Cancer Genes

Covers sustaining proliferation in cancer cells, growth factors, receptor tyrosine kinases, signal transduction, viral oncogenes, and therapeutic opportunities.

Protein Phosphorylation: Mechanisms and Regulation

Explores protein phosphorylation, its structural effects, kinase activity, and its role in signaling and disease.

Cell Signalling: Receptors and Pathways

Explores cell signalling mechanisms, including receptors, pathways, and signal transduction for gene regulation and cellular responses.

Cell Membrane Receptors: General Principles

Explains cell membrane receptors, signal transduction, and second messengers.

Enzyme Drug Targets

Explores enzyme drug targets, tyrosine kinase inhibitors, vascular tone control, and viral life cycle interventions.

GPCRs: Molecular Endocrinology

Explores the structure and activation of 7TM receptors and the downstream effects of CAMP and protein kinase A.

Cell Signalling: Eucaryotes

Explores cell signalling in eukaryotic cells, focusing on G proteins, Ras, and receptor tyrosine kinases.

Receptors and Targeting

Explores receptors, ligands, and their role in signal transduction, including the activation of the immune system and the significance of multivalency in receptor-ligand interactions.

Insulin Receptor Activation: Signaling Mechanisms

Explains insulin receptor activation and cytokine receptor signaling mechanisms in detail.

Membrane Binding Domains: PIP Signaling Pathway

Explores the role of membrane binding domains in the PIP signaling pathway and the recognition of PIPx species by specific domains.

Altered Pathways in Cancer: Signaling Cascades and Mutations

Explores cancer pathways, major signaling cascades, and mutations in RAS and BRAF genes.

Pharmacological Targets and Interventions

Explores targets for drug action and the design of specific inhibitors.

Pharmacology: Drug Targets and Mechanisms

Discusses ligand-receptor binding, drug targets, insulin physiology, NSAIDs, and tyrosine kinase inhibitors.

Nuclear Receptors: Signalling and Health Implications

Explores nuclear receptors, JAK-STAT pathway, growth factors, endocrine disruptors, and estrogen receptors.