Publications related to Coronary arteries

Leukocyte Count and Coronary Artery Disease Events in People With Human Immunodeficiency Virus: A Longitudinal Study

Jacques Fellay, Christian Axel Wandall Thorball

Leukocyte count is associated with coronary artery disease (CAD) events in the general population. Here we show that leukocytes are independently associated with CAD events in people with HIV in Switzerland, after adjusting for traditional and HIVrelated r ...

OXFORD UNIV PRESS INC2023

Associations of genetic and infectious risk factors with coronary heart disease

Jacques Fellay, Flavia Aurelia Shoko Hodel, Christian Axel Wandall Thorball, Zhi Ming Xu, Roxane De La Harpe

Coronary heart disease (CHD) is one of the most pressing health problems of our time and a major cause of preventable death. CHD results from complex interactions between genetic and environmental factors. Using multiplex serological testing for persistent ...

eLIFE SCIENCES PUBL LTD2023

Polygenic Risk Scores for Prediction of Subclinical Coronary Artery Disease in Persons Living With HIV: The Swiss HIV Cohort Study

Jacques Fellay, Christian Axel Wandall Thorball

Background. In people living with human immunodeficiency virus (HIV) (PLWH), individual polygenic risk scores (PRSs) are associated with coronary artery disease (CAD) events. Whether PRSs are associated with subclinical CAD is unknown. ...

OXFORD UNIV PRESS INC2022

The interplay between human genetic variation, chronic inflammation and persistent infection: relevance for cardiovascular morbidity

Flavia Aurelia Shoko Hodel

Contemporary genomic approaches allow us to seek answers to biological questions that were previously out of reach. Genome-wide association studies (GWAS) have identified numerous genetic polymorphisms associated with human diseases, providing new insight ...

EPFL2022

Coronary Artery Disease-Associated and Longevity-Associated Polygenic Risk Scores for Prediction of Coronary Artery Disease Events in Persons Living With Human Immunodeficiency Virus: The Swiss HIV Cohort Study

Jacques Fellay, Christian Axel Wandall Thorball

Background: Coronary artery disease (CAD) is in part genetically determined. Aging is accentuated in people with human immunodeficiency virus (HIV) (PLWH). It is unknown whether genetic CAD event prediction in PLWH is improved by applying individual polyge ...

OXFORD UNIV PRESS INC2021

Predicting future myocardial infarction from angiographies with deep learning

Pascal Frossard, Emmanuel Abbé, Ortal Yona Senouf, Olivier Muller, Ntorina Thanou, Thabodhan Mahendiran, Omar Raita, Stéphane Fournier, David Meier, Nicolas Dayer, Farhang Aminfar

In patients with stable Coronary Artery Disease (CAD), the identification of lesions which will be responsible of a myocardial infarction (MI) during follow-up remains a daily challenge. In this work, we propose to predict culprit stenosis by applying a de ...

2021

Considerations for analysis of endothelial shear stress and strain in FSI models of atherosclerosis

Lydia Aslanidou, Fotios Savvopoulos

Atherosclerosis is a lipid driven chronic inflammatory disease that is characterized by the formation of plaques at predilection sites. These predilection sites (side branches, curved segments, and bifurcations) have often been associated with disturbed sh ...

ELSEVIER SCI LTD2021

Model order reduction of flow based on a modular geometrical approximation of blood vessels

Simone Deparis, Luca Pegolotti

We are interested in a reduced order method for the efficient simulation of blood flow in arteries. The blood dynamics is modeled by means of the incompressible Navier–Stokes equations. Our algorithm is based on an approximated domain-decomposition of the ...

2021

Improvement of a Closed Chest Porcine Myocardial Infarction Model by Standardization of Tissue and Blood Sampling Procedures

Jonas Alfred Karl Wilbs

Myocardial ischemia reperfusion (I/R) injury contributes to almost half of the necrotic area after myocardial infarction. To date there is no approved drug to prevent or reduce myocardial I/R injury. The study and understanding of the pathophysiological me ...

JOURNAL OF VISUALIZED EXPERIMENTS2018

Computational study of the risk of restenosis in coronary bypasses

Alfio Quarteroni, Christian Vergara

Coronary artery disease, caused by the buildup of atherosclerotic plaques in the coronary vessel wall, is one of the leading causes of death in the world. For high-risk patients, coronary artery bypass graft is the preferred treatment. Despite overall exce ...

Springer Heidelberg2017

Photodynamic therapy for the treatment of atherosclerotic plaque: Lost in translation?

Hubert van den Bergh, Georges Wagnières, Matthieu Philippe Emmanuel Zellweger, Manish Jain

Acute coronary syndrome is a life-threatening condition of utmost clinical importance, which, despite recent progress in the field, is still associated with high morbidity and mortality. Acute coronary syndrome results from a rupture or erosion of vulnerab ...

Wiley2017

Numerical modeling of hemodynamics scenarios of patient-specific coronary artery bypass grafts

Alfio Quarteroni, Gianluigi Rozza, Andrea Manzoni, Elena Faggiano

A fast computational framework is devised to the study of several configurations of patient-specific coronary artery bypass grafts. This is especially useful to perform a sensitivity analysis of the hemodynamics for different flow conditions occurring in n ...

Springer Heidelberg2017

A computational fluid-structure interaction analysis of coronary Y-grafts

Alfio Quarteroni, Christian Vergara

Coronary artery disease is one of the leading causes of death worldwide. The stenotic coronary vessels are generally treated with coronary artery bypass grafts (CABGs), which can be either arterial (internal mammary artery, radial artery) or venous (saphen ...

Elsevier Sci Ltd2017

Ultrafast laser ablation for targeted atherosclerotic plaque removal

Laurent Descloux, Demetri Psaltis, Donald Benjaman Conkey, Thomas Jean Victor Marie Lanvin

Coronary artery disease, the main cause of heart disease, develops as immune cells and lipids accumulate into plaques within the coronary arterial wall. As a plaque grows, the tissue layer (fibrous cap) separating it from the blood flow becomes thinner and ...

Spie-Int Soc Optical Engineering2015

Development of Implantable Electrodes Based on Polymer Derived Ceramics

Jonas Grossenbacher

The invention of heart pacemakers in the 50's aims to help patients to overcome heart strokes, which represent the first cause of death worldwide. In Europe and in the USA, more than 3000 pacemakers are implanted every day. Despite the constant evolution o ...

EPFL2015

SUMOylation-Dependent LRH-1/PROX1 Interaction Promotes Atherosclerosis by Decreasing Hepatic Reverse Cholesterol Transport

Kristina Schoonjans, Alessia Perino, Dongryeol Ryu, Vera Monica Lemos Da Silva, Xu Wang, Chikage Mataki, Pan Xu, Keir Joe Menzies, Matthias Alexander Sokrates Stein, Maaike Hélène Oosterveer

Reverse cholesterol transport (RCT) is an antiatherogenic process in which excessive cholesterol from peripheral tissues is transported to the liver and finally excreted from the body via the bile. The nuclear receptor liver receptor homolog 1 (LRH-1) driv ...

Cell Press2014

Privacy-Preserving Computation of Disease Risk by Using Genomic, Clinical, and Environmental Data

Jean-Pierre Hubaux, Jacques Fellay, Erman Ayday, Jean Louis Raisaro, Paul Jack Mc Laren

According to many scientists and clinicians, genomics is the "next big thing" in the field of medicine. On one hand, decreasing costs in genome sequencing has been paving the way to better preventive and personalized medicine. On the other hand, genomic da ...

2013

Contribution of Genetic Background, Traditional Risk Factors, and HIV-Related Factors to Coronary Artery Disease Events in HIV-Positive Persons

Jacques Fellay, Amalio Telenti, Xuan Li

Background. Persons infected with human immunodeficiency virus (HIV) have increased rates of coronary artery disease (CAD). The relative contribution of genetic background, HIV-related factors, antiretroviral medications, and traditional risk factors to CA ...

Oxford University Press2013

Shape optimization for viscous flows by reduced basis methods and free-form deformation

Alfio Quarteroni, Gianluigi Rozza, Andrea Manzoni

In this paper we further develop an approach previously introduced in [Lassila and Rozza, C.M.A.M.E 2010] for shape optimization that combines a suitable low-dimensional parametrization of the geometry (yielding a geometrical reduction) with reduced basis ...

Wiley-Blackwell2012

Increasing Haptic Fidelity and Ergonomics in Teleoperated Surgery

Laura Santos Carreras

Over the past few decades, surgical procedures have made enormous progress, shifting from traditional open procedures to less and less invasive approaches, with the promise of smaller incisions, less complications, better cosmetic results and shorter recov ...

EPFL2012